Xiaoyun Ding
Associate Professor • Bruce S. Anderson Assistant Professor • Biomedical, Micro/Nanoscale, Thermo Fluid Sciences

Office Location: ECES 158
Lab Location: ECES 117

<h2>Research Interests</h2>

<p><strong><span>Biomedical microfluidics, intracellular delivery, drug delivery, lab on chip, cellular engineering</span></strong></p>

<p style="margin:0in; margin-bottom:.0001pt"><span>Xiaoyun Ding’s research group centers on the innovation of cutting-edge micro/nano systems for cell based biomedical applications, including micro/nano manipulation of cell and fluid, cell membrane disruption and repair, and precise intracellular/subcellular delivery. Our research is highly interdisciplinary at the frontiers of micro/nano engineering, biomedical engineering, acoustics, electronics, and other applied physics. </span></p>

<p style="margin:0in; margin-bottom:.0001pt"> </p>

<h2 style="margin:0in 0in 0.0001pt">Societal Impact</h2>

<p>We strive to improve human health and life quality through innovations in engineering cell functions for cell-based immunotherapy and reducing costs of disease diagnostics and therapeutics.</p>

<h2>Select Publications</h2>

<ul class="list-style-icon-3">
<li>Gazendra Shakya, Tao Yang, Yu Gao, Apresio K. Fajrial, Baowen Li, Massimo Ruzzene, Mark A. Borden, and Xiaoyun Ding. Manipulating Internal Structure of Endoskeletal Droplets using Acoustic Waves. <em>Nature Communication</em>, 13 (1), 1-9, (2022).</li>
<li>Yu Gao, Apresio K Fajrial, Tao Yang, Xiaoyun Ding. Emerging On-chip Surface Acoustic Wave Technology for Small Biomaterials Manipulation and Characterization, <em>Biomaterials Science</em>, 9.5: 1574-1582. (2021). (<strong>Back</strong> <strong>cover story</strong>) </li>
<li>Apresio K. Fajrial, Kun Liu, Yu Gao, Junhao Gu, Richard Lakerveld, and Xiaoyun Ding. Characterization of single-cell osmotic swelling dynamics for new physical biomarkers, <em>Analytical Chemistry</em>, 2020. (<strong>Front cover story</strong>)</li>
<li>Apresio Kefin Fajrial, Qing Qing He, Nurul I. Wirusanti, Jill Slansky, and Xiaoyun Ding. A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing. <em>Theranostics</em>, 10(12):5532-5549. (2020).</li>
<li>Yonghui Ding, Kerri A. Ball, Kristofor J. Webb, Yu Gao, Angelo D’Alessandro, William M. Old, Michael H.B. Stowell, Xiaoyun Ding. On-chip Acousto Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability, <em>Small</em>, 2003506, 2020. (<strong>Front Cover Story</strong>)</li>
<li>Gazendra Shakya, Samuel E. Hoff, Shiyi Wang, Hendrik Heinz, Xiaoyun Ding and Mark A. Borden. Vaporizable endoskeletal droplets via tunable interfacial melting transitions. <em>Science Advances</em> 6.14: eaaz7188, (2020).</li>
<li>Apresio Fajrial, Xiaoyun Ding, Advanced Nanostructures for Cell Membrane Poration. <em>Nanotechnology</em>, 30, 264002, (2019)</li>
<li>Xiaoyun Ding, Martin Stewart, Armon Sharei, James Weaver, Robert Langer, and Klavs Jensen, <a href="http://dx.doi.org/10.1038/s41551-017-0039" title="http://dx.doi.org/10.1038/s41551-017-0039">High-throughput nuclear delivery and rapid expression of DNA via mechanical and electrical cell-membrane disruption<em>.</em> </a><em>Nature Biomedical Engineering</em>, 1, 0039 (2017)</li>
<li>Martin P Stewart, Armon Sharei, Xiaoyun Ding, Gaurav Sahay, Robert Langer, Klavs F Jensen, <a href="http://dx.doi.org/10.1038/nature19764" title="http://dx.doi.org/10.1038/nature19764">In vitro and ex vivo strategies for intracellular delivery.</a> <em>Nature</em> 538 (7624), 183-192 (2016)</li>
<li>Xiaoyun Ding, <em>et al</em>., <a href="http://dx.doi.org/10.1073/pnas.1413325111" title="http://dx.doi.org/10.1073/pnas.1413325111">Cell separation using tilted-angle standing surface acoustic waves, </a>Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111, 12992-12997 (2014).</li>
<li>Xiaoyun Ding, <em>et al</em>., <a href="https://doi.org/10.1039/C3LC50361E" title="https://doi.org/10.1039/C3LC50361E">Surface acoustic wave (SAW) microfluidics, </a>Lab on a Chip, 13, 3626-3649 (2013).</li>
<li>Xiaoyun Ding, <em>et al</em>., <a href="https://doi.org/10.1073/pnas.1209288109" title="https://doi.org/10.1073/pnas.1209288109">On-Chip Manipulation of Single Microparticles, Cells, and Organisms Using Surface Acoustic Waves, </a>Proceedings of the National Academy of Sciences of the United States of America (PNAS), 109, 11105-11109 (2012).</li>
<li>Xiaoyun Ding, <em>et al</em>.,<a href="https://pubs.rsc.org/en/content/articlelanding/2012/lc/c2lc40751e#!divAb... title="https://pubs.rsc.org/en/content/articlelanding/2012/lc/c2lc40751e#!divAb... Standing surface acoustic wave (SSAW) based multichannel cell sorting,</a> Lab on a Chip, 12, 4228–4231 (2012). (<strong>Cover Image</strong>)</li>
<li>Xiaoyun Ding, <em>et al</em>., <a href="https://pubs.rsc.org/en/content/articlelanding/2012/lc/c2lc21021e#!divAb... title="https://pubs.rsc.org/en/content/articlelanding/2012/lc/c2lc21021e#!divAb... Patterning of Microparticles and Cells using Standing Surface Acoustic Waves, </a>Lab on a Chip, 12, 2491-2497 (2012). (<strong>Cover image</strong>)</li>

<h2>Select Awards</h2>

<ul class="list-style-icon-3">
<li>2022  The Penn State Graduate School Alumni Society Early Career Award (1 awardee worldwide yearly)</li>
<li>2021  NIH MIRA Early Stage Investigator Award </li>
<li>2021  Bruce S. Anderson Engineering Faculty Fellow, University of Colorado </li>
<li>2020  Lab Venture Challenge 2020 winner, Colorado </li>
<li>2020  Biomaterials Science Emerging Investigators 2021</li>
<li>2019  W. M. Keck Foundation Medical Research Grant Award</li>
<li>2019  CCTSI Novel Method Development Pilot Awards, Colorado</li>
<li>2013  Rustum and Della Roy Innovation in Materials Research Award, The Penn State University</li>
<li>2013  Inventor Incentive Award, The Penn State University</li>
<li>2013  Journal of Laboratory Automation Ten Breakthroughs in Innovation Award (JALA Ten 2013)</li>
<li>2012  Student Paper Competition Award, IEEE International Ultrasonics Symposium, Dresden, Germany </li>
<li>2012  The Baxter Young Investigator Award, Chicago, USA (6 awardees nationwide)</li>
<li>2012  First Place Award at Penn State ESM Today Graduate Research Symposium, The Penn State University</li>
<li>2011  Innovation Award at Penn State ESM Today Graduate Research Symposium,  The Penn State University</li>

<p> </p>