Office: JSCBB A224
BS, University of Wyoming (1998)
PhD, University of Colorado (2002)
- A.C. Daly, M.E. Prendergast, A.J. Hughes, J.A. Burdick, Bioprinting for the Biologist, Cell, 184:18-32 (2021).
- A.C. Daly, M.D. Davidson, J.A. Burdick, 3D Printing of High Cell-Density Heterogenous Tissue Models through Spheroid Fusion within Self-Healing Hydrogels, Nature Communications, 12:753 (2021).
- J.A. Zepp, M.P. Morley, C. Loebel, M.M. Kremp, F.N. Chaudhry, M.C. Basil, J.P. Leach, D.C. Liberti, T.K. Niethamer, Y. Ying, S. Jayachandran, A. Babu, S. Zhou, D.B. Frank, J.A. Burdick, E.E. Morrisey, Genomic, Epignomic, and Biophysical Cues Controlling the Emergence of the Lung Alveolus, Science, 371:eabc3172 (2021).
- A.C. Daly, L.A. Riley, T. Segura, J.A. Burdick, Hydrogel Microparticles for Biomedical Applications, Nature Reviews Materials, 5:20-43 (2020).
- M.D. Davidson, E. Ban, A.C.M. Schoonen, M.H. Lee, M. D’Este, V.B. Shenoy, J.A. Burdick, Mechanochemical Adhesion and Plasticity in Multi-fiber Hydrogel Networks, Advanced Materials, 32:1905719 (2020).
- M.E. Prendergast and J.A. Burdick, Recent Advances in Enabling Technologies in 3D Printing for Precision Medicine, Advanced Materials, 32:1902516 (2020).
- C.B. Highley, K.H. Song, A.C. Daly, J.A. Burdick, Jammed Microgel Inks for 3D Printing Applications, Advanced Science, 6:1801076 (2019).
- C. Loebel, R.L. Mauck, J.A. Burdick, Local Nascent Protein Deposition and Remodeling Guide Mesenchymal Stromal Cell Mechanosensing and Fate in Three-dimensional Hydrogels, Nature Materials, 18:883-891 (2019).
- S.L. Vega, M.Y. Kwon, K.H. Song, C. Wang, R.L. Mauck, L. Han, J.A. Burdick, Combinatorial Hydrogels with Biochemical Gradients for Screening 3D Cellular Microenvironments, Nature Communications, 9:614 (2018).
- J.E. Mealy, J.J. Chung, H.H. Jeong, D. Issadore, D. Lee, P. Atluri, J.A. Burdick, Injectable Granular Hydrogels with Multifunctional Properties for Biomedical Applications, Advanced Materials, 30:1705912 (2018).
- K.H. Song, C.B. Highley, A. Rouff, J.A. Burdick, Complex 3D-printed Microchannels within Cell-degradable Hydrogels, Advanced Functional Materials, 28:1801331 (2018).
- L. Ouyang, C.B. Highley, W. Sun, J.A. Burdick, A Generalizable Strategy for the 3D Printing of Hydrogels from Non-viscous Photocrosslinkable Inks, Advanced Materials, 29:1604983 (2017).
- C. Loebel, C.B. Rodell, M.H. Chen, J.A. Burdick, Shear-thinning and Self-healing Hydrogels as Injectable Therapeutics and for 3D-Printing, Nature Protocols, 12:1521-1541 (2017).
- L.L. Wang, Y. Liu, J.J. Chung, T. Wang, A.C. Gaffey, M. Lu, C.A. Cavanaugh, S. Zhou, R. Kanade, P. Atluri, E.E. Morrisey, J.A. Burdick, Sustained miRNA Delivery from an Injectable Hydrogel Promotes Cardiomyocyte Proliferation and Functional Regeneration after Ischaemic Injury, Nature Biomedical Engineering, 1:983-992 (2017).
- S.R. Caliari and J.A. Burdick, A Practical Guide to Hydrogels for Cell Culture, Nature Methods, 13:405-414 (2016).
- C.B. Rodell, N.N. Dusaj, C.B. Highley, J.A. Burdick, Injectable and Cytocompatible Tough Double-Network Hydrogels Through Tandem Supramolecular and Covalent Crosslinking, Advanced Materials, 28:8419-8424 (2016).
- R.J. Wade, E.J. Bassin, C.B. Rodell, J.A. Burdick, Protease Degradable Electrospun Fibrous Hydrogels, Nature Communications, 6:6639 (2015).
- C.B. Highley, C.B. Rodell, J.A. Burdick, Direct 3D Printing of Shear-thinning Hydrogels into Self-healing Hydrogels, Advanced Materials, 27:5075-5079 (2015).
- B.M. Baker, B. Trappmann, W.Y. Wang, M.S. Sakar, I.L. Kim, V.B. Shenoy, J.A. Burdick, C.S. Chen, Cell-Mediated Fiber Recruitment Drives Extracellular Matrix Mechanosensing in Engineered Fibrillar Microenvironments, Nature Materials, 14:1262-1268 (2015).
- B.P. Purcell, D. Lobb, M.B. Charati, S.M. Dorsey, R.J. Wade, K.N. Zellars, H. Doviak, S. Pettaway, C.B. Logdon, J.A. Shuman, C. Novak, J.H. Gorman, R.C. Gorman, F.G. Spinale, J.A. Burdick, Injectable and Bioresponsive Hydrogels for On-Demand Matrix Metalloproteinase Inhibition, Nature Materials, 13:653-661 (2014).
- S. Khetan, M. Guvendiren, W.R. Legant, D.M. Cohen, C.S. Chen, J.A. Burdick, Degradation-mediated Cellular Traction Directs Stem Cell Fate in Covalently Crosslinked Three-dimensional Hydrogels, Nature Materials, 12:458-465 (2013).
Jason Burdick and his Biomaterials and Biofabrication Laboratory design new biomaterials that can be processed through fabrication methodologies to meet the needs of medicine, ranging from translational therapeutics to tissue models. Based in fundamental materials science, the group synthesizes cytocompatible and cell-instructive biomaterials, often from biopolymers (e.g., hyaluronic acid) that are crosslinked into water-swollen hydrogels and biodegradable elastomers. Many of the biomaterials are designed to be shear-thinning and self-healing through the incorporation of dynamic and reversible interactions of polymers or microparticles. Biomaterials from the group are processed with a range of techniques, including electrospinning, microfluidics, and 3D printing (e.g., extrusion printing, stereolithography) to control their structure and subsequent function across applications. The field of biofabrication is growing rapidly and the Burdick Laboratory is designing new materials and processing methods to meet challenges within the field.
Recent applications of work from the group include: (i) injectable hydrogels to treat myocardial tissue after myocardial infarction to limit adverse tissue remodeling; (ii) bioprinting of tissue models (e.g., cardiac) for the screening of therapeutics; (iii) fibrous scaffolds for fibrocartilage tissue repair (e.g., meniscus) and as models of fibrosis; and (iv) hydrogels to improve cartilage repair through therapeutic delivery to the joint or to promote adult stem cell chondrogenesis. Common across all of these examples is the innovative design of new materials to meet specific criteria (e.g., degradation, mechanics, cell-interactions) for the intended biomedical application.