B.A., Columbia University (2002)
Ph.D., University of California, Berkeley (2007)
- NAE Frontiers of Engineering, US Meeting Participant, 2016
- NIH Director’s New Innovator Award, 2014-2019
- NIH K99/R00 Pathway to Independence Award in Cancer Nanotechnology, 2010-2015
- DOD Breast Cancer Postdoctoral Fellowship Award, 2010-2013
- AACR Scholar-in-Training Award, 2011
- NIH T32 Postdoctoral Fellowship, 2008-2010
A. Yildirim,* R. Chattaraj, N. T. Blum, D. Shi, K. Kumar, and A. P. Goodwin.* “Phospholipid Capped Mesoporous Nanoparticles for Targeted High Intensity Focused Ultrasound Ablation.” Adv. Healthcare Mater. In press.
N. T. Blum, A. Yildirim, R. Chattaraj, and A. P. Goodwin.* “Nanoparticles Formed by Acoustic Destruction of Microbubbles and Their Utilization for Imaging and Effects on Therapy by High Intensity Focused Ultrasound.” Theranostics. 2017, 7, 694-702.
G. R. Hafenstine, K. Ma, A. W. Harris, O. Yehezkeli, E. Park, D. W. Domaille, J. N. Cha,* and A. P. Goodwin.* “Multicatalytic Light-Driven Upgrading of Butanol to 2-Ethylhexenal and Hydrogen at Mild Aqueous Conditions.” ACS Catalysis. 2017, 7, 568-572.
R. Chattaraj, G. M. Goldscheitter, A. Yildirim, and A. P. Goodwin.* "Enhanced Acoustic Vaporization of Perfluorocarbon Nanodroplets due to Phase Behavior of Mixed Lipid Monolayers." RSC Adv. 2016, 6, 111318–111325.
A. Yildirim,* R. Chattaraj,+ N. T. Blum,+ A. P. Goodwin.* “Understanding Acoustic Cavitation Initiation by Porous Nanoparticles: Toward Nanoscale Agents for Ultrasound Imaging and Therapy.” Chem. Mater. 2016, 28, 5962–5972.
K. Kumar, E. J. Castano, A. R. Weidner, and A. P. Goodwin.* “Depolymerizable Poly(vinyl carbamate-alt-sulfones) as Customizable Macromolecular Mucosal Drug Delivery Scaffolds.” ACS Macro Lett. 2016, 5, 636-640.
K. Kumar and A. P. Goodwin.* “Alternating Sulfone Copolymers Depolymerize in Response to Both Chemical and Mechanical Stimuli.” ACS Macro Lett. 2015, 4, 907-911.
K. R. Fitch and A. P. Goodwin.* “A Mechanochemical Reaction Cascade for Sensitive Detection of Covalent Bond Breakage in Hydrogels.” Chem. Mater. 2014, 26, 6771-6776.
P. Mohan, P. S. Noonan, M. A. Nakatsuka, and A. P. Goodwin.* “On-Demand Droplet Fusion: A Strategy for Stimulus-Responsive Biosensing in Solution.” Langmuir. 2014, 30, 12321–12327.
M. A. Nakatsuka, C. V. Barback, K. R. Fitch, A. R. Farwell, R. F. Mattrey, S. C. Esener, J. N. Cha, and A. P. Goodwin.* “In Vivo Ultrasound Visualization of Non-Occlusive Blood Clots with Thrombin-Sensitive Contrast Agents.” Biomaterials. 2013, 34, 9559-9565.
* indicates corresponding author
Colloid and interface science, polymer science and engineering, self-assembly, chemical synthesis, imaging, drug delivery, cancer research.
Our research is focused on the interplay between chemical properties at the molecular scale and materials properties at the nano- and microscale. Through careful design of interfacial structure and function, we are creating “smart” colloids and materials – such as polymeric architectures, organic/inorganic hybrids, and multiphase composites – that can sense their surroundings and react accordingly. This reaction results in transmission of information, release of encapsulated contents, or change of local surface and material properties, and applications for such systems include imaging, drug delivery, catalysis, sensing, and renewable materials, among others. We are also interested in how interfaces organize themselves when sensing chemical stimuli, and how they respond to external forces. We are exploring these phenomena in both natural and synthetic systems through a combination of chemical design, colloid and surface engineering, and microscopy.