Research from PhD candidate Garrett Chado and Professors Mark Stoykovich and Joel Kaar has been highlighted on the August 2016 cover of ACS Catalysis.
The article addresses previous gaps in understanding about how the density and arrangement of enzymes affect the way they react when affixed to surfaces. Interestingly, while a dependence on spatial arrangement and, specifically, nearest-neighbor distance was apparent for enzymes that were diffusion-limited at high enzyme densities, such a dependence was negligible for enzymes that were reaction-limited. Such findings have important implications for the design of catalytic cascades on scaffolds and may simplify the engineering of such multi-enzyme cascade structures.
The full article, titled “Role of Dimension and Spatial Arrangement on the Activity of Biocatalytic Cascade Reactions on Scaffolds,” is available on the ACS Catalysis website.