Wilderness Place 235   100x confocal IL1R1 neuron
2860 Wilderness Place
Boulder, CO 80309-0354
Phone: (303) 735-4601

Research Interests

To determine how chronic insufficient sleep induces, or contributes to inflammatory disease.

Personnel

  • DirectorMark R. Opp, PhD
  • Laboratory Manager: Amrita George
  • Research Assistant: Gabriel Costanza-Chavez
  • Undergraduate Students: Daniel Bush, Anneli Folkesson, Hannah Pfromer, Brianna Hormberg, Annie Betts
  • Previous Students: Christopher Thompson

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(L to R): Anneli Folkesson, Gabriel Costanza-Chavez, Brianna Hormberg, Hannah Pfromer, Mark Opp, Amrita George, Annie Betts, Daniel Bush.

Current Research Projects

  • Mechanisms by which sleep disruption induces inflammation in the brains of mice.
  • Sleep disruption and chronic musculoskeletal pain.
  • Traumatic brain injury-induced alterations in sleep.

Opportunities for Undergraduates

Opportunities for Graduate Students 

  • Graduate student training is available contingent upon research funding.
  • For more information contact Dr. Opp at Mark.Opp@colorado.edu.

Oppurtunities for Postdoctoral Fellows

  • The Opp lab is currently recruiting prospective postdoctoral scholars. If interested please contact Dr. Opp at Mark.Opp@colorado.edu

Recent Publications

  • Davis CJ, Dunbrasky D, Oonk M, Taishi P, Opp MR, Krueger JM. The neuron-specific interleukin-1 receptor accessory protein is required for homeostatic sleep and sleep responses to influenza viral challenge. Brain, Behavior and Immunity 47: 35-43, 2015.
  • Febinger H, Thomasy H, Pavlova M, Ringgold K, Barf P, George A, Grillo J, Bachstetter A, Cardona A, Garcia J, Opp MR, Gemma C. CX3CR1 dictates the classical and alternative microglia phenotype shift in a mouse model of mild traumatic brain injury. Journal of Neuroinflammation 12: 154, 2015.
  • Ho JM, Barf RP, Opp MR. Effects of sleep disruption and high fat intake on glucose metabolism in mice. Psychoneuroendocrinology 68: 47-56, 2016.
  • Ingiosi AM, Opp MR. Sleep and immunomodulatory responses to systemic lipopolysaccharide in mice selectively expressing interleukin-1 receptor 1 on neurons or astrocytes. GLIA 64: 780-791. 2016.
  • Ingiosi AM, Raymond RM, Pavlova MN, Opp MR. Selective contributions of neuronal and astroglial interleukin-1 receptor 1 to the regulation of sleep. Brain, Behavior, and Immunity48: 244-257, 2015.
  • Kozachik SL, Opp MR, Page GG. Recovery sleep does not mitigate the effects of prior sleep loss on paclitaxel-induced mechanical hypersensitivity in Sprague-Dawley rats.Biological Research for Nursing 17: 207-213, 2015.
  • Opp MR, George A, Ringgold KM, Hansen KM, Bullock KM, Banks WA. Sleep fragmentation and sepsis differentially impact blood-brain barrier integrity and transport of tumor necrosis factor-α in aging. Brain, Behavior, and Immunity 50: 259-265, 2015.
  • Page GG, Opp MR, Kozachik SL. Sex differences in sleep, anhedonia, and HPA axis activity in a rat model of chronic social defeat. Neurobiology of Stress 3: 105-113, 2016.
  • Sutton BC, Opp MR. Acute increases in intramuscular inflammatory cytokines are necessary for the development of mechanical hypersensitivity in a mouse model of musculoskeletal sensitization. Brain, Behavior and Immunity 44: 213-220, 2015.
  • Thomasy HE, Febinger HY, Ringgold KM, Gemma C, Opp MR. Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury. Neurobiology of Sleep and Circadian Rhythms 2: 71-84, 2017.
  • Thomasy HE, Febinger HY, Ringgold KM, Gemma C, Opp MR. Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury. Neurobiology of Sleep and Circadian Rhythms 2: 71-84, 2017.

Funding

  • 2014 - 2018 1R01NR014479 Microbiome and Pain in IBS (PI: Heitkemper; co-I: Opp)
  • 2016 - 2021 2R01NS025378 Interleukin-1: A Promoter of Slow Wave Sleep (PI:Krueger; co-PI Opp)