DeSouza lab logo showing cardiovascular systemRamaley, Room W206
phone: 303-735-3605
 

Research Interests

  • The effects of aging, cardiovascular and metabolic risk factors, and habitual physical activity on vascular endothelial function.

Personnel

Current Research Projects

  • Influence of age, obesity, exercise, and oxidative stress on the endothelin-1 system.
  • HIV-1 infection, vascular endothelial function, and exercise.
  • Effects of nebivolol on ET-1 vasoconstrictor tone.
  • Nebivolol and endothelial regulation of fibrinolysis.
  • Overweight/obesity and vascular progenitor cell function.

Recent Publications

  • Stockelman KA, Bain AR, Goulding A, DeSouza NM, Rahaman C, Maly L, Greiner JJ, Stauffer BL, DeSouza CA. Negative Influence of Insufficient Sleep on Endothelial Vasodilator and Fibrinolytic Function in Hypertensive Adults. Hypertension. 2021,78(6):1829-1840.
  • Stockelman KA, Bain AR, Dow CA, Diehl KJ, Greiner JJ, Stauffer BL, DeSouza CA. Regular aerobic exercise counteracts endothelial vasomotor dysfunction associated with insufficient sleep. American Journal of Physiology Heart and Circulatory Physiology. 2021,320(3):H1080-H1088.
  • Brewster LM, Bain AR, Garcia VP, Fandl HK, Stone R, DeSouza NM, Greiner JJ, Tymko MM, Vizcardo-Galindo GA, Figueroa-Mujica RJ, Villafuerte FC, Ainslie PN, DeSouza CA. Global REACH 2018: dysfunctional extracellular microvesicles in Andean highlander males with excessive eryhtrocytosis. American Journal of Physiology Heart and Circulatory Physiology. 2021, 320(5):H1851-H1861.
  • DeSouza NM, Brewster LM, Bain AR, Garcia VP, Stone R, Stockelman KA, Greiner JJ, Tymko MM, Vizcardo-Galindo G, Figueroa-Mujica RJ, Villafuerte FC, Ainslie PN, DeSouza CA. Global REACH 2018: Influence of excessive erythrocytosis on coagulation and fibrinolytic factors in Andean highlanders. Experimental Physiology. 2021,106(6):1335-1342.
  • Stockelman KA, Hijmans JG, Bammert TD, Greiner JJ, Stauffer BL, DeSouza CA. Circulating endothelial cell derived microvesicles are elevated with hypertension and associated with endothelial dysfunction. Canadian Journal of Physiology and Pharmacology. 2020;98(8):557-561.
  • Brewster LM, Garcia VP, Levy MV, Stockelman KA, Goulding A, DeSouza NM, Greiner JJ, Hijmans JG, DeSouza CA. Endothelin-1-induced endothelial microvesicles impair endothelial cell function. Journal of Applied Physiology. 2020;128(6):1497-1505.
  • Brewster LM, Coombs GB, Garcia VP, Hijmans JG, DeSouza NM, Stockelman KA, Barak OF, Mijacika T, Dujic Z, Greiner JJ, Phillips AA, Ainslie PN, DeSouza CA. Effects of circulating extracellular microvesicles from spinal cord-injured adults on endothelial cell function. Clinical Science. 2020;134(7):777-789.
  • Bain AR, Holland RL, Donnelly J, Nowak-Fluck D, Sekhon M, Tymko MM, Greiner JJ, DeSouza CA, Ainslie PN. Cerebral metabolism, oxidation and inflammation in severe hyperthermia with and without respiratory alkalosis. Journal of Physiology. 2020;598(5):943-954.