Seals Lab research 2018 AugustCarlson 1B06
Phone: 303-735-6410
Fax: 303-492-6778

Research Focus

The research goals of the Integrative Physiology of Aging Laboratory are to determine:

  • important changes in physiological function with aging;
  • modulation of those changes by biological factors (e.g., adiposity, vitamin D/estrogen status) and lifestyle behaviors (e.g., physical activity/inactivity, diet);
  • the efficacy of interventions, both lifestyle and pharmacological (including "nutraceuticals"), for reversing adverse changes in physiological function with aging;
  • the integrative (systemic to molecular) biological mechanisms that mediate physiological changes with aging and the effects of modulating influences and interventions on those changes.

Within this context of the integrative physiology of aging, a primary focus is "vascular aging", in particular the development of large elastic artery stiffness and impaired arterial endothelial function with advancing age. A recently added direction of interest involves assessing decreases in motor and cognitive function with aging and the ability of potential healthspan-extending interventions to improve age-associated reductions in motor/cognitive performance.

A wide range of contemporary experimental techniques are employed to study these issues in human subjects, rodents, and cell culture using cross-sectional, intervention, and longitudinal study designs. Emphasis is placed on the integrative nature of the physiological and pathophysiological processes involved from a mechanistic perspective.

Our research on human subjects is performed in the University of Colorado Boulder Clinical Translational Research Center (CTRC). If you are interested in participating, please review the Volunteers Needed page and contact one of the investigators.

The laboratory provides scientific training from the undergraduate to postdoctoral levels, and is supported by individual investigator (R01 and R21), fellowship (F31, F32, K01) and institutional training grant (T32) awards from the National Institutes of Health.

See our Facebook page to learn more about activities in our laboratory.

Opportunities for Undergraduates

To learn more about research opportunities for undergraduates in our laboratory, see the undergraduate research application page. Our needs change each semester so if we are not currently bringing in new undergrads, please check back.

Personnel

  • Senior Professor: Douglas R. Seals, Ph.D.
  • Postdoctoral Fellows: Vienna Brunt, Ph.D., Zach Clayton, Ph.D., Daniel Craighead, Ph.D., Matt Rossman, Ph.D.
  • Masters Students: Abby Casso, Kaiti Freeberg, Jake Frye, Tom Heinbockel, Erzsie Nagy, Nick VanDongen
  • Concurrent BA/MS Program: Kathy Nguyen.
  • Undergraduate Students: Philip Goldman, Makinzie Hamilton, Kayla Woodward.
  • Staff Research Assistants: Rachel Adams-Jackman, B.S., Amy Bazzoni, B.A., Marissa Burnsed-Torres, M.S., Jill Miyamoto-Ditmon, B.S., Cindy Seals, B.A., Brian Ziemba, Ph.D., Melanie Zigler, M.S.
  • Collaborators: Tom LaRocca, Ph.D. and Matt McQueen, Ph.D., University of Colorado Boulder; Chris Gentile, Ph.D., and Mike Pagliassotti, Ph.D., Colorado State University; Kristen Jablonski, Ph.D. and Michel Chonchol, M.D., UC-Denver Anschutz Medical Campus; Nichole Reisdorph, Ph.D., National Jewish Health, Denver.

Seals Lab 2018 August

Back Row: Nick VanDongen, Doug Seals, Brian Ziemba, Amy Bazzoni, Jamie Richey, Daniel Craighead, Matt Rossman, Zach Clayton
Middle Row: Makinzie Hamilton, Jill Miyamoto-Ditmon, Melanie Zigler, Kathy Nguyen, Rachel Adams-Jackman, Erzsie Nagy, Marissa Burnsed-Torres, Kaiti Freeburg, Vienna Brunt, Kara Lubieniecki, Abby Casso, Lindsey Jankowski
Front Row: Kayla Woodward, Jake Frye, Tom Heinbockel

Highlighted Articles

Recent Publications

For a complete list of publications click here.

  • Seals DR, Brunt VE, Rossman MJ. Keynote lecture: strategies for optimal cardiovascular aging. American Journal of Physiology Heart and Circulatory Physiology 315: H000–H000, 2018. First published April 13, 2018; doi:10.1152/ajpheart.00734.2017.
  • Rossman, M, Santos-Parker J, Steward C, Bispham N, Cuevas L, Rosenberg H, Woodward K, Chonchol M, Gioscia-Ryan R, Murphy M, Seals D. Chronic supplementation with a mitochondrial antioxidant (MitoQ) improves vascular function in healthy older adults. Hypertension 71:1056-1063, 2018. Pubmed PMID:29661838
  • Johnson LC, Martens CR, Santos-Parker JR, Bassett CJ, Strahler TR, Cruickshank-Quinn C, Reisdorph N, McQueen MB, Seals DR. Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with aging in humans. Clinical Science 2018 Jun18:CS20180409.
  • Martens, CR, Denman BA, Mazzo MR, Armstrong M, Reisdorph N, McQueen MB, Chonchol M, Seals DR. Chronic nicotinamide riboside is well-tolerated and effectively elevates NAD+ in healthy middle-aged/older adults. Nature Communications 2018 Mar 29;9(1):1286. doi: 10.1038/s41467-018-03421-7. Pubmed PMID: 29599478.
  • Gioscia-Ryan, RA, Battson ML, Cuevas LM, Eng JS, Murphy MP, Seals DR.  Mitochondrial-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice. Journal of Applied Physiology 124:1194-1202, 2018.