The research goals of the Integrative Physiology of Aging Laboratory are to determine:
- important changes in physiological function with aging;
- modulation of those changes by biological factors (e.g., adiposity, vitamin D/estrogen status) and lifestyle behaviors (e.g., physical activity/inactivity, diet);
- the efficacy of interventions, both lifestyle and pharmacological (including "nutraceuticals"), for reversing adverse changes in physiological function with aging;
- the integrative (systemic to molecular) biological mechanisms that mediate physiological changes with aging and the effects of modulating influences and interventions on those changes.
Within this context of the integrative physiology of aging, a primary focus is "vascular aging", in particular the development of large elastic artery stiffness and impaired arterial endothelial function with advancing age. A recently added direction of interest involves assessing decreases in motor and cognitive function with aging and the ability of potential healthspan-extending interventions to improve age-associated reductions in motor/cognitive performance.
A wide range of contemporary experimental techniques are employed to study these issues in human subjects, rodents, and cell culture using cross-sectional, intervention, and longitudinal study designs. Emphasis is placed on the integrative nature of the physiological and pathophysiological processes involved from a mechanistic perspective.
Our research on human subjects is performed at the University of Colorado Boulder Clinical Translational Research Center (CTRC). If you are interested in participating, please review the Volunteers Needed page and contact one of the investigators.
The laboratory provides scientific training from the undergraduate to postdoctoral levels, and is supported by individual investigator (R01 and R21), fellowship (F31, F32, K01) and institutional training grant (T32) awards from the National Institutes of Health.
See our Facebook page to learn more about activities in our laboratory.
Opportunities for Undergraduates
To learn more about research opportunities for undergraduates in our laboratory, see the undergraduate research application page. Our needs change each semester so if we are not currently bringing in new undergrads, please check back.
- Senior Professor: Douglas R. Seals, Ph.D.
- Lab Manager: Melanie Zigler, M.S.
- Biochemistry Core Director: Kate Ludwig, Ph.D.
- Research Assistant Professors: Vienna Brunt, Ph.D., Matt Rossman, Ph.D., Daniel Craighead, Ph.D.
- Postdoctoral Fellows: Zachary Clayton, Ph.D., Kevin Murray, Ph.D., Yara Bernaldo de Quirós, Ph.D.
- Ph.D. Candidates: Abby Casso, Kaiti Freeberg, Nathan Greenberg
- Masters Students: Sophia Mahoney, Grace Maurer, McKinley Coppock, Sanna Darvish, Ravi Venkatasubramanian, Hannah Lally (visiting student)
- Undergraduate Students: Lucy Egan, Monvi Kudumula, Alex Lindquist, Ashley Darrah
- Professional Research Assistants: Jill Miyamoto-Ditmon, B.S., Nick VanDongen, M.S., Morgan Berryman-Maciel, M.S., Aaron Lange, B.S., Narissa McCarty, M.S., Emily Adam, B.S., Cindy Seals, B.A.
- Collaborators: Matt McQueen, Ph.D., University of Colorado Boulder; Tom LaRocca, Ph.D., Chris Gentile, Ph.D., and Mike Pagliassotti, Ph.D., Colorado State University; Kristen Jablonski, Ph.D. and Michel Chonchol, M.D., UC-Denver Anschutz Medical Campus.
- Santos-Parker JR, LaRocca TJ, Seals DR. Aerobic exercise and other healthy lifestyle factors that influence vascular aging. Advances in Physiology Education 38:296-307, 2014.
- Seals D, Melov S. Preclinical Studies: Track function in ageing animals. Nature 511: 406-407, 2014.
- Seals DR, Melov S. Translational Geroscience: Emphasizing function to achieve optimal longevity. Aging 6(9): 718-730, 2014.
- Seals DR. Edward F. Adolph Distinguished Lecture: The remarkable anti-aging effects of aerobic exercise on systemic arteries. Journal of Applied Physiology 117: 425-439, 2014.
- Seals D, Santos-Parker J, LaRocca T. Translational physiology in practice. Physiology News 2014(96): 38-42, 2014.
- Seals DR. Translational physiology: from molecules to public health. Journal of Physiology 591(14): 3457-3469, 2013.
In the News Media
For a complete list of publications click here.
- Seals DR, Brunt VE, Rossman MJ. Keynote lecture: strategies for optimal cardiovascular aging. American Journal of Physiology Heart and Circulatory Physiology 315: H183–H188, 2018.
- Rossman, M, Santos-Parker J, Steward C, Bispham N, Cuevas L, Rosenberg H, Woodward K, Chonchol M, Gioscia-Ryan R, Murphy M, Seals D. Chronic supplementation with a mitochondrial antioxidant (MitoQ) improves vascular function in healthy older adults. Hypertension 71:1056-1063, 2018. Pubmed PMID:29661838
- Johnson LC, Martens CR, Santos-Parker JR, Bassett CJ, Strahler TR, Cruickshank-Quinn C, Reisdorph N, McQueen MB, Seals DR. Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with aging in humans. Clinical Science 2018 Jun18:CS20180409.
- Martens, CR, Denman BA, Mazzo MR, Armstrong M, Reisdorph N, McQueen MB, Chonchol M, Seals DR. Chronic nicotinamide riboside is well-tolerated and effectively elevates NAD+ in healthy middle-aged/older adults. Nature Communications 2018 Mar 29;9(1):1286. doi: 10.1038/s41467-018-03421-7. Pubmed PMID: 29599478.
- Gioscia-Ryan, RA, Battson ML, Cuevas LM, Eng JS, Murphy MP, Seals DR. Mitochondrial-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice. Journal of Applied Physiology 124:1194-1202, 2018.