Sleep and Chronobiology Laboratory

Administrative Research Center (ARC), Room A29

3100 Marine Street
Boulder, CO 80309-0554
phone: 303-735-1923
fax: 303-735-2864

Research Interests

  • Health and safety consequences of sleep and circadian disruption.

  • Influence of sleep and circadian rhythms on human physiology (neuroendocrine, metabolic and immune function) and behavior (sleepiness, memory, learning, mood, cognitive and motor performance) with application to public health and safety.

  • Countermeasures to improve sleep, wakefulness, and health.

Personnel

  • Director: Kenneth P. Wright Jr., Ph.D.
  • Assistant Research Professor: Josiane L. Broussard, Ph.D.
  • Postdoctoral Fellows: Tina M. Burke, Ph.D., Christopher M. Depner, Ph.D., and Kate Sprecher, Ph.D.
  • Graduate Students: Molly Guerin, B.A., Taylor Marshall, B.A., and Hannah K. Ritchie, M.S.
  • Undergraduate Students: Brandon Abell, Minhaz Ali, Paul Bisesi, Alivia Blumenstein, Dasha Cogswell, Monaz Engineer, Noah Henry, Michael Kim, Brent Knud-Hansen, Shannon Lanza, Sabrina Linton, Jessa Marsh, Emilee Mickaliger, Claire Ramer, Bailey Reagan, Leah Rotenbakh, Stefanie Rowsell, Alex Smits, Dhipi Srinivasan, Emily Villaseñor, Lauren Walters, Ben Wharton, Jessica Wu.
  • Professional Research Assistants: Chelsea Arent, B.A., Julie Compton, B.A., Jeffrey Higdon, B.A., Anna Klochak, M.S., Oliver Knauer, B.A., Sarah Morton, M.S., Gayle Wright, MSW, LCSW.
Front Row (L to R): Leah Rotenbakh, Mesa Lynch, Jessica Wu, Emilee Mickaliger, Shannon Lanza, Alex Smits, Hannah Ritchie, Molly Guerin
Second Row (L to R): Emily Villasenor, Monaz Engineer, Claire Ramer, Dhipi Srinivasan, Kate Sprecher, Sabrina Linton, Alivia Blumenstein, Bailey Reagan, Julie Compton, Chelsea Arent, Josie Broussard
Third Row (L to R): Kenneth Wright, Michael Kim, Stefanie Rowsell, Minhaz Ali, Noah Henry, Dasha Cogswell, Paul Bisesi, Brandon Abell, Brent Knud-Hansen, Jessa Marsh, Chris Depner, Jeff Higdon, Taylor Marshall, Ben Wharton, Anna Klochak

Current Research Projects

  • Impact of sleep and circadian disruption on the human microbiome and related changes in human physiology and cognition.
  • Biomarkers for insufficient sleep and circadian rhythm disruption (metabolomics and proteomics).
  • Tissue specific alterations in response to insufficient sleep and circadian misalignment.
  • Influence of sleep loss, sleep inertia and circadian disruption on cognitive function.
  • Countermeasures to improve sleep and wakefulness.
  • Physiological and behavioral mechanisms by which insufficient sleep and circadian misalignment contributes to metabolic dysregulation.
  • Countermeasures to improve cardiometabolic health during insufficient sleep.
  • Student-athlete sleep, health and performance.

Persons interested in volunteering to participate in one of these studies should visit the sleep study participant page.

Colorado Sleep and Circadian Research Symposium

  • Fourth Annual Colorado Sleep and Circadian Research Symposium
    June 1, 2017 8AM-3PM - Keynote Speaker: Prof. Mark Opp.
    Meeting details
  • Past meetings - 2016 | 2015 | 2014

Opportunities for Undergraduate Students

  • The requirements for undergraduate students who want a research experience in our Laboratory are:
    • A strong desire to obtain research experiences prior to graduate school, medical school, or advanced study in a health-related field
    • Minimum commitment: One year
    • Minimum hours/week when testing subjects: 8-10 hours (includes journal club)
    • Minimum experience: No prior experience required
    • Must be willing to work with a team
    • Must be able to work various hours during the day, at night, and on weekends.

  • UROP, independent study, honors thesis, and concurrent BA-MS opportunities are available.

  • For more information, contact Anna.Klochak@colorado.edu.

Opportunities for Graduate Students and Postdoctoral Fellows

  • Graduate Student and Postdoctoral Fellow training is available contingent upon research funding.
  • For more information, contact kenneth.wright@colorado.edu.

Videos

Camping Syncs Internal Clock with Nature (Entrainment of the Human Circadian Clock to the Natural Light-Dark Cycle). Production and Editing: Brandon R. Griffin.

Recent Publications

Funding

  • 2016-2018, NIH R01 HL132150 NIH/NHLBI, "Biomarkers of Insufficient Sleep and Sleepiness" (PI: Wright, Reisdorph).
  • 2015-2020, N00014-15-1-2809, Office of Naval Research (ONR), "The microbiome and responsiveness to stress: Countermeasure strategies for improving resilience to sleep and circadian disruption" (PI and Team Lead: Wright).
  • 2016-2020, NIH R01 HL135598, NIH/NHLBI, "Sleep and Blood Pressure-Related Endothelial Abnormalities" (PI: Wright, Desouza, Stauffer).
  • 2016-2019, NIH R01 HL131458, NIH/NHLBI, "HIV-1, Insufficient Sleep and Vascular Endothelial Dysfunction" (PI: Desouza, Connick; Wright Co-Investigator).
  • 2012-2018, NIH U01 HL111478, NIH/NHLBI, "Multi-Center Trial of Limiting PGY2&3 Resident Work Hours on Patient Safety" (PI (Colorado): Wright).
  • 2016-2018, Pac-12 Grant , "Health and Performance: Pac-12 Center for Student-Athlete Health and Performance” (PI: McQueen; Wright Co-Investigator).
  • 2016-2019, Mentored Research Scientist Development Award NIH K01 DK110138, NIH/NIDDK, "Effects of physical activity on cardiometabolic impairments associated with insufficient sleep" (PI: Broussard).
  • 2016-2018, University of Colorado, Vice Chancellor of Research Innovative Seed Grant Program (PI: Broussard).
  • 2011-2017, Society in Science—The Branco Weiss Fellowship (PI: Broussard).
  • 2017-2019, Postdoctoral Individual National Research Service Award, F32 DK111161, NIH/NIDDK, "Mechanisms of Insufficient Sleep Contributing to Metabolic Disease Risk and Impact from ‘Weekend Recovery’ Sleep" (PI: Depner).
  • 2017-2018, Center for Women's Health Research Faculty Research Development Award, "Examining sex differences in the metabolic response to insufficient sleep" (PI: Broussard).
  • 2017-2018, University of Colorado Clinical and Translational Research Center Microgrant Award, "Tissue-specific effects of insufficient sleep" (PI: Broussard).
  • 2017-2018 Colorado Nutrition Obesity Research Center (NORC, P30DK048520), "Impact of insufficient sleep on peripheral metabolic tissues" (PI: Broussard).