Mark J. Kastantin

Mark J. Kastantin
Assistant Research Professor



Ph.D. (Chemical Engineering), University of California, Santa Barbara, 2009
B.S. (Chemical Engineering), Massachusetts Institute of Technology, 2003
B.S. (Brain and Cognitive Sciences), Massachusetts Institute of Technology, 2003


  • Ruth L. Kirschstein NRSA postdoctoral fellowship, National Institutes of Health, 2010-2012
  • American Institute of Chemists Postdoctoral Award, 2012

Selected Publications

  • Marullo, R.; Kastantin, M.; Drews, L. B.; Tirrell, M., Peptide Contour Length Determines Equilibrium Secondary Structure in Protein-Analogous Micelles. Biopolymers. 2013, 99, 573-581.
  • Kastantin, M. and Schwartz, D. K., DNA Hairpin Stabilization on a Hydrophobic Surface. Small2013,9, 933-941.
  • Kastantin, M.; Walder, R.; Schwartz, D. K., Identifying Mechanisms of Interfacial Dynamics Using Single-Molecule Tracking. Langmuir 2012, 28, 12443-12456.
  • Kastantin, M.; Keller, T. F.; Jandt, K. D.; Schwartz, D. K., Single-Molecule Tracking of Fibrinogen Dynamics on Nanostructured Polyethylene Films. Adv. Funct. Mater.2012, 22, 2617-2623.
  • Langdon, B.; Kastantin, M.; Schwartz, D. K., Apparent Activation Energies Associated with Protein Dynamics on Hydrophobic and Hydrophilic Surfaces. Biophys. J. 2012, 102, 2625-2633.
  • Kastantin, M. and Schwartz, D. K., Connecting rare DNA conformations and surface dynamics using single-molecule resonance energy transfer. ACS Nano2011, 5, 9861-9869.
  • Kastantin, M. and Tirrell, M., Helix formation in the polymer brush.Macromolecules2011, 44, 4977-4987.
  • Kastantin, M.; Langdon, B. B.; Chang, E. L.; Schwartz, D. K., Single-molecule resolution of interfacial fibrinogen behavior: Effects of oligomer populations and surface chemistry. J. Am. Chem. Soc.2011, 133, 4975-4983.
  • Kastantin, M.; Missirlis, D.; Black, M.; Ananthanarayanan, B.; Tirrell, M., Thermodynamic and kinetic stability of DSPE-PEG(2000) micelles in the presence of bovine serum albumin. J. Phys. Chem. B2010, 114, 12632-12640.
  • Peters, D.; Kastantin, M.; Kotamraju, V. R.; Karmali, P. P.; Gujraty, K.; Tirrell, M.; Ruoslahti, E., Targeting atherosclerosis using modular, multifunctional micelles. Proc. Natl. Acad. Sci. U.S.A.2009,106, 9815-9819.
  • Kastantin, M.; Ananthanarayanan, B.; Karmali, P.; Ruoslahti, E.; Tirrell, M., Effect of the lipid chain melting transition on the stability of DSPE-PEG(2000) micelles. Langmuir2009,25, 7279-7286.
  • Karmali, P. P.; Kotamraju, V. R.; Kastantin, M.; Black, M.; Missirlis, D.; Tirrell, M.; Ruoslahti, E., Targeting of albumin-embedded paclitaxel nanoparticles to tumors. Nanomed.-Nanotechnol. 2009,5, 73-82.

Research Interests

Bioinspired materials, single-molecule microscopy methods, drug delivery, biomolecules at interfaces, polymer self-assembly