Distinguished Professor, Tisone Professor, Associate Professor of Surgery, and Howard Hughes Medical Institute Investigator
Anseth Research Group
B.S., Purdue University (1992)
Ph.D., University of Colorado (1994)
- Elected to the National Academy of Sciences (2013)
- Hazel Barnes Award, University of Colorado (2013)
- Mid-Career Research Award, Materials Research Society (2012)
- Distinguished Engineering Alumni Award, Purdue University (2012)
- Distinguished Research Lecturer, University of Colorado (2011)
- Elected to the Institute of Medicine of the National Academies (2009)
- Professional Progress Award, American Institute of Chemical Engineers (2009)
- Elected to the National Academy of Engineering (2009)
- Named as one of the ‘Brilliant 10’ Scientists,Popular Science (2008)
- Named one of the “One Hundred Chemical Engineers of the Modern Era”, AIChE (2008)
- Distinguished Engineering Alumni Award, Research and Teaching, University of Colorado (2008)
- Clemson Award for Basic Research, Society for Biomaterials (2008)
- Alan T. Waterman Award, National Science Foundation (2004)
- Allan P. Colburn Award, American Institute of Chemical Engineers (2003)
- Curtis W. McGraw Award, American Society for Engineering Education (2003)
- David and Lucile Packard Fellowship for Science and Engineering (1997)
- S. Wang, L.A. Leinwand and K.S. Anseth, “The cells and their matrix microenvironment in cardiac valves,” Nature Reviews Cardiology, 11, 715-27 (2014).
- C. Yang, M.W. Tibbitt, L. Basta and K.S. Anseth,“Mechanical memory and dosing influence stemcell fate,” Nature Materials, 13, 645-652 (2014).
- D.D. McKinnon, D.W. Domaille, J.N. Cha and K.S. Anseth, “Covalently adaptable networks as biophysical ECM mimics for cell culture,” Advanced Materials, 26, 865-72 (2014).
- M.A. Azagarsamy and K.S. Anseth, “Wavelength controlled photo-cleavage of multiple proteins for orthogonal and sequential release,” Angewandte Chemie, 52, 13803-807 (2013).
- H. Wang, M.W. Tibbitt, S.J. Langer, L.A. Leinwand and K.S. Anseth,” Hydrogels preserve native phenotypes of valvular fibroblasts through an elasticity-regulated PI3K/AKT pathway,” Proceedings of the National Academy of Sciences, 110, 19336-341 (2013).
- D.D. McKinnon, A.M. Kloxin and K.S. Anseth, “Synthetic hydrogel platform for three-dimensional culture of ES motor neurons,” Biomaterials Science, 1, 460-69 (2013).
- M.W. Tibbitt and K.S. Anseth, “Dynamic environments: The fourth dimension,” Science Translational Medicine, 4,160ps24 (2012).
- H. Wang, S.M. Haeger, A.M. Kloxin, L.A. Leinwand and K.S. Anseth, “Redirecting valvular myofibroblasts into dormant fibroblasts through light-mediated reduction in substrate modulus,” PLoS ONE, 7, Article Number e39969 (2012).
- M.A. Azagarsamy, D.L. Alge, S.J. Radhakrishman, M.W. Tibbitt and K.S. Anseth, “Photocontrolled nanoparticles for intracellular on-demand release of proteins,” Biomacromolecules,13, 2219-24 (2012).
- C.A. DeForest and K.S. Anseth, “Photoreversible patterning of biomolecules within click-based hydrogels,” Angewandte Chemie,51, 1816-19 (2012).
- C.A. DeForest and K.S. Anseth, “Cytocompatible click-based hydrogels with dynamically-tunable properties through orthogonal photoconjugation and photocleavage reactions,” Nature Chemistry, 3,925-31 (2011).
- C. Lin and K.S. Anseth, “Cell-cell communication mimicry with PEG hydrogels for enhancing b-cell function,” Proceedings of the National Academy of Sciences, 108, 6380-85 (2011).
- A.M. Kloxin, M.W. Tibbitt and K.S. Anseth, “Synthesis of photodegradable hydrogels as dynamically tunable materials for 2D and 3D cell culture,” Nature Protocols, 5, 1-21 (2010).
- B.D. Fairbanks, M.P. Schwartz, A.E. Halevi, C.R. Nuttelman, C.N. Bowman and K.S. Anseth, “A versatile synthetic extracellular matrix mimic through thiol-ene photopolymerization,” Advanced Materials,21, 5005-10 (2009).
- C.A. DeForest, B.D. Polizzotti and K.S. Anseth, “Sequential click reactions for synthesizing and patterning 3D cell microenvironments,” Nature Materials,8, 659-64 (2009).
- A.M. Kloxin, A.M. Kasko, C.N. Salinas and K.S. Anseth,“ Photolabile hydrogels for dynamic tuning of physical and chemical properties,” Science,324,59-63 (2009).
- D.S.W. Benoit, M.J Schwartz, A.R. Durney and K.S. Anseth, “Small molecule functional groups for the controlled differentiation of human mesenchymal stem cells encapsulated in poly(ethylene glycol) hydrogels,” Nature Materials,7,816 - 823 (2008).
Biomaterials, Tissue Engineering, Photopolymerizations, and Degradable Polymer Networks
Many of the current biomaterials in clinical use today were originally developed for other applications, and such off-the-shelf materials became a biomaterial when someone pursued the trial-and-error process of implanting the material and "seeing what happens." In contrast to this approach, our group is pursuing new directions towards the rational design of biomaterials and, specifically, how photopolymerization processes can be used to provide numerous advantages for medical applications. For the past few years, we have been exploring, designing, and characterizing new generations of multifunctional macromers that can be photopolymerized to form degradable networks, where the degradation is predictable and readily controlled. From a biomaterial perspective, photoinitiated polymerizations are beneficial for many reasons including fast curing rates under physiological conditions, spatial and temporal control of the polymerization, and the ability to generate complex 3D structures in situ. The resulting degradable networks are advantageous since they circumvent the need for implant retrieval and are useful in applications ranging from controlled release of drugs to tissue engineering scaffolds. Currently, ongoing projects in our group include the design of new orthopaedic biomaterials for fracture fixation, photoencapsulation of chondrocytes for cartilage tissue engineering, biomimetic approaches to heart valve tissue engineering, microfluidic bioassays, photopolymerization of micro and nanoparticles for drug delivery, DNA delivery for tissue engineering applications, and photopolymerizable tissue adhesives. Our research combines a mixture of polymer chemistry and physics, molecular and cellular biology, and molecular simulations and modeling with fundamental engineering principles to address problems of importance to the fields of biomaterials and tissue engineering.