Daniel K. Schwartz

Dan SchwartzAlfred T. and Betty E. Look Professor and
Chair of the Department of Chemical and Biological Engineering
JSCBB D121
(303) 735-0240
daniel.schwartz@colorado.edu
Curriculum Vitae
Schwartz Research Group

Education

Ph. D. in Physics, Harvard University (1991)
A.B. summa cum laude in Chemistry and Physics, Harvard University (1984)

Awards

  • Elected Fellow of the American Physical Society in the Division of Condensed Matter Physics (2011)
  • CU-Boulder College of Engineering Faculty Research Award (2010)
  • Boulder Faculty Assembly Award for Excellence in Research (2008)
  • Camille Dreyfus Teacher-Scholar Award (1999)
  • NSF Career Award (1998)
  • Mortarboard Honor Society Salute for Excellence in Teaching (3 times, 1997-1999)
  • Camille & Henry Dreyfus Foundation New Faculty Award (1994)


Selected Publications

  • Mark Kastantin, Robert Walder and Daniel K. Schwartz, Langmuir, 28, 12443-12456 (2012) “Identifying Mechanisms of Interfacial Dynamics Using Single-Molecule Tracking” (Feature Article)
  • Mark Kastantin, Thomas F. Keller, Klaus D. Jandt, and Daniel K. Schwartz, Advanced Functional Materials, 22, 2617-2623 (2012) “Single-Molecule Tracking of Fibrinogen Dynamics on Nanostructured Poly(ethylene) Films”
  • Robert Walder, Nathaniel Nelson, and Daniel K. Schwartz, Nature Communications, 2, 515 (2011) “Super-Resolution Surface Mapping using the Trajectories of Molecular Probes”
  • Mark Kastantin and Daniel K. Schwartz, ACS Nano, 5, 9861-9869 (2011) “Connecting Rare DNA Conformations and Surface Dynamics using Single-Molecule Resonance Energy Transfer”
  • Robert Walder, Nathaniel Nelson, Daniel K. Schwartz, Physical Review Letters, 107, 156102 (2011) “Single Molecule Observations of Desorption-Mediated Diffusion at the Solid-Liquid Interface”
  • Robert Walder and Daniel K. Schwartz, Soft Matter, 7, 7616-7622 (2011) “Dynamics of Protein Aggregation at the Oil-Water Interface Characterized by Single Molecule TIRF Microscopy”
  • Mark Kastantin, Blake B. Langdon, Erin L. Chang, and Daniel K. Schwartz, J. Am. Chem. Soc., 133, 4975-4983 (2011) “Single-molecule Resolution of Interfacial Fibrinogen Behavior: Effects of Oligomer Populations and Surface Chemistry”
  • Stephen T. Marshall, Marykate O’Brien, Brittany Oetter, April Corpu, Ryan M. Richards, Daniel K. Schwartz, J. William Medlin, Nature Materials, 9, 853-858 (2010) “Controlled Selectivity for Palladium Catalysts using Self-assembled Monolayers”
  • Andrei Honciuc, Daniel K. Schwartz, J. Am. Chem. Soc. 131, 5973-5979 (2009) “Probing Hydrophobic Interactions using Trajectories of Amphiphilic Molecules at a Hydrophobic/Water Interface”
  • Andrew D. Price, and Daniel K. Schwartz, J. Am. Chem. Soc., 130, 8188-8194 (2008) “DNA Hybridization-Induced Reorientation of Liquid Crystal Anchoring at the Nematic Liquid Crystal/Aqueous Interface”
  • Siwar Trabelsi, Shishan Zhang, T. Randall Lee, Daniel K. Schwartz, Phys. Rev. Lett., 100, 037802 (2008) “Linactants: Surfactant Analogues in Two Dimensions”


Research Interests

Interfacial phenomena, Biomolecules at interfaces, Surface modification via molecular self-assembly, Single-molecule microscopy methods, Nanoscale surface structures.

Biomolecules at Interfaces:
Biomacromolecules, like proteins and DNA, interact in complex ways at interfaces. We are studying the structural changes that occur when proteins and oligonucleotides adsorb at solid surfaces and at the air/water interface using a combination of single-molecule tracking fluorescence microscopy, interfacial rheology, atomic force microscopy, and infrared spectroscopy. We are particularly interested in understanding how intramolecular structural changes (e.g. protein unfolding) affect intermolecular interactions such as aggregation, surface fouling, and the formation of interfacial gels. This has applications in a number of areas, including the stability of pharmaceutical proteins as well as food colloids.

Biosensing at Interfaces:
We are interested in the interactions between surface chemistry and molecular recognition, such as DNA hybridization or protein-ligand binding. The competition between these types of specific interactions and non-specific interfacial adsorption is often the limiting factor in DNA technologies such as microarrays and single-molecule sequencing. Our research aims to develop ways to control non-specific interactions while promoting specific binding. We are also developing ways to use liquid crystals to detect specific molecular interactions at interfaces. Liquid crystalline materials are incredibly sensitive to small changes in the structure and chemistry of interfaces. This sensitivity, combined with the fact that liquid crystals can be used in simple optical displays, makes them very promising as read-out elements for biosensors (see figure below).

Surface Modification using Self-assembled Monolayers:
Self-assembled monolayers (SAMs) represent a versatile coating technology with applications in biocompatibility, nanotechnology, biosensors, corrosion resistance, and molecular electronics. We study the growth and structure of SAMs, ultra-thin molecular films adsorbed from solution on solid surfaces, using single molecule fluorescence microscopy, atomic force microscopy, and spectroscopic techniques, in an effort to develop a deeper understanding of monolayer growth so that this technology will become applicable to a wider variety of substrate materials and applications. Technological applications of current interest in our group include self-organized strategies for the creation of nano-patterned surfaces (the fabrication of molecular "dots" and "lines"), chemical modification of metal catalysts to improve selectivity, modification of biomaterials and membranes to control non-specific adsorption, and development of novel surfaces for liquid crystal alignment.

Polarized microscope imagesMolecular Organization in Surfactant Monolayers:
The organization of molecules at fluid/fluid interfaces are directly related to the stability and dynamics of foams and emulsions. These systems are also important models for cell membranes and are of fundamental interest because of their quasi-two dimensional character. We use specialized optical microscopy techniques (fluorescence and Brewster angle microscopy) to study the complicated phase behavior of monolayers at the air/water interface. Our recent work in this area involves the discovery of “linactant” compounds, molecules that preferentially adsorb to two-dimensional phase boundaries in order to reduce the interfacial energy (i.e. the line tension). Such molecules are believed to have an important role in controlling the heterogeneous structure of cell membranes (i.e. lipid rafts).