Goodwin Research Group
B.A., Columbia University (2002)
Ph.D., University of California, Berkeley (2007)
- NIH K99 Pathway to Independence Award in Cancer Nanotechnology, 2010-2015
- DOD Breast Cancer Postdoctoral Fellowship Award, 2010-2013
- AACR Scholar-in-Training Award, 2011
- NIH T32 Postdoctoral Fellowship, 2008-2010
- UC Berkeley Graduate Travel Grant, 2005
- National Merit Scholar, 1998
- M. A. Nakatsuka, R. F. Mattrey, S. C. Esener, J. N. Cha,* and A. P. Goodwin.* “Aptamer-Crosslinked Microbubbles: Smart Contrast Agents for Thrombin-Activated Ultrasound Imaging.” Advanced Materials. Accepted.
- M. A. Nakatsuka, M. J. Hsu, S. C. Esener,* J. N. Cha,* and A. P. Goodwin.* “DNA-Coated Microbubbles with Biochemically-Tunable Ultrasound Contrast Activity.” Adv. Mater. 2011, 23, 4908-4912.
- M. A. Nakatsuka, J. H. Lee, E. Nakayama, A. M. Hung, M. J. Hsu, R. F. Mattrey, S. C. Esener,* J. N. Cha,* and A. P. Goodwin.* “Facile One-Pot Synthesis of Polymer-Phospholipid Composite Microbubbles with Enhanced Drug Loading Capacity for Ultrasound-Triggered Therapy.” Soft Matter. 2011, 7, 1656-1659.
- M. J. Hsu, M. Eghtedari, A. P. Goodwin, R. F. Mattrey, D. J. Hall, and S. C. Esener. “Characterization of individual ultrasound microbubble dynamics with a light-scattering system.” J. Biomed. Opt. 2011, 16, 067002.
- A. P. Goodwin, S. M. Tabakman, K. Welsher, S. P. Sherlock, G. Prencipe, and H. Dai. “Phospholipid-Dextran with a Single Coupling Point: a Useful Amphiphile for Functionalization of Nanomaterials.” J. Am. Chem. Soc. 2009, 131, 289-296.
- Z. Chen, S. M. Tabakman, A. P. Goodwin, M. G. Kattah, D. Daranciang, X. Wang, G. Zhang, X. Li, Z. Liu, P. J. Utz, K. L. Jiang, S. S. Fan, and H. Dai. “Protein microarrays with carbon nanotubes as multicolor Raman labels.” Nature Biotechnol. 2008, 26, 1285-1292.
- A. P. Goodwin, S. S. Lam, J. M. J. Fréchet. “Rapid, Efficient Synthesis of Heterobifunctional Biodegradable Dendrimers.” J. Am. Chem. Soc. 2007, 129, 6994-6995.
- J. L. Mynar, A. P. Goodwin, J. A. Cohen, Y-Z. Ma, G. R. Fleming, J. M. J. Fréchet. “Two-photon Degradable Supramolecular Assemblies of Linear-Dendritic Copolymers.” Chem. Commun. 2007, 20, 2081-2082.
- A. P. Goodwin, J. L. Mynar, Y-Z. Ma, G. R. Fleming, J. M. J. Fréchet. “Synthetic Micelle Sensitive to IR Light Via a Two-Photon Process.” J. Am. Chem. Soc. 2005, 127, 9952-9953.
- E. R. Gillies, A. P. Goodwin, J. M. J. Fréchet. “Acetals as pH-Sensitive Linkages for Drug Delivery.” Bioconjugate Chem. 2004, 15, 1254-1263.
Colloid and interface science, polymer science and engineering, self-assembly, chemical synthesis, imaging, drug delivery, cancer research.
Our research is focused on the interplay between chemical properties at the molecular scale and materials properties at the nano- and microscale. Through careful design of interfacial structure and function, we are creating “smart” colloids and materials – such as polymeric architectures, organic/inorganic hybrids, and multiphase composites – that can sense their surroundings and react accordingly. This reaction results in transmission of information, release of encapsulated contents, or change of local surface and material properties, and applications for such systems include imaging, drug delivery, catalysis, sensing, and renewable materials, among others. We are also interested in how interfaces organize themselves when sensing chemical stimuli, and how they respond to external forces. We are exploring these phenomena in both natural and synthetic systems through a combination of chemical design, colloid and surface engineering, and microscopy.