NIH Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional) Solicitation

Program Summary 

Superfund Research Program (SRP) Center grants will support problem-based, solution-oriented research Centers that consist of multiple, integrated projects representing both the biomedical and environmental science and engineering disciplines; as well as cores tasked with administrative (which includes research translation), data management and analysis, community engagement, research experience and training coordination, and research support functions. The scope of the SRP Centers is taken directly from the Superfund Amendments and Reauthorization Act of 1986, and includes: (1) advanced techniques for the detection, assessment, and evaluation of the effect on human health of hazardous substances; (2) methods to assess the risks to human health presented by hazardous substances; (3) methods and technologies to detect hazardous substances in the environment; and (4) basic biological, chemical, and physical methods to reduce the amount and toxicity of hazardous substances. Applicants are expected to design a research Center that integrates biomedical research (e.g., toxicology, epidemiology, mechanistic studies) with environmental science and engineering (e.g., remediation, geochemical, ecological sciences).  The goal of the NIEHS SRP Center is to improve public health by supporting integrative, multidisciplinary research incorporating the following: responsiveness to mandates; problem-based, solution-oriented research; relevance to SRP and Superfund; innovation; and integration.

Applicants are highly encouraged to consult with SRP staff for specific questions about the relevancy of a hazardous substance for this FOA. The SRP will place priority on research with a clear connection to understanding health effects relevant to populations living near or affected by sites impacted by hazardous substances.  In addition, applicants are encouraged to pursue toxicological endpoints for chemicals lacking toxicological data that are also found at Superfund sites.

Applications should consist of the following components:

  • Research Projects: maximum of 6
    • Biomedical Research Projects: required, minimum of 2; maximum of 4
    • Environmental Science and Engineering Research Projects: required, minimum of 2; maximum of 4
  • Cores: minimum of 4; maximum of 6
    • Administrative Core: required
    • Data Management and Analysis Core: required
    • Community Engagement core: required
    • Research Experience and Training Coordination  Core: required
    • Research Support Core(s): optional, maximum of 2

Note: Applications must successfully meet these minimum requirements (4 required projects, 4 required cores (Administrative Core, Data Management and Analysis Core, Community Engagement Core, and Research Experience and Training Coordination Core)) without exceeding a total of 11 projects and cores. At least one of the Environmental Science and Engineering Research Projects must support SRP's fourth mandate: "Basic biological, chemical, and physical methods to reduce the amount and toxicity of hazardous substances."


CU Internal Deadline: 11:59pm MST August 21, 2018

Sponsor Letter of Intent (optional) Deadline: November 19, 2018

Sponsor Full Application Deadline: 5:00pm MST December 19, 2018

Internal Application Requirements (all in PDF format)

  • Project Summary (2-3 pages): Please include the primary project site, problem being addressed by the Center, how the Center plans to solve target problem(s), proposed science, primary activities, and benefits of the Center in terms of improving public health. Also address the relevance of the Center’s activities to public health, SRP stakeholders, and the Superfund Research Program. Per the solicitation, the SRP seeks to improve relevance through encouraging applicants to design problem-based, solution-oriented research to address the needs of its stakeholders (e.g., the agencies responsible for management of sites impacted by hazardous substances, as well as the individuals and communities impacted by these sites).
  • PI Biosketch / CV
  • List of co-PIs (if applicable) (Up to 1 page): Please include the names, titles, departmental and institutional affiliation(s), and project role(s).
  • Budget Overview (Up to 1 page): A basic budget outlining project costs is sufficient; detailed OCG budgets are not required.

To access the online application, visit:


Only Higher Education Institutions may apply to this P42 FOA.

Limited Submission Guidelines

Only one application per institution is allowed.

Award Information and Duration

Award Amount: Applications may request a budget for direct costs of up to $1.75 million dollars for each year.

Number of Awards: Up to 12.

Award Term: Up to 5 years.