NIH NIGMS Human Genetic Cell Repository Solicitation

Please see the full solicitation for complete information about the funding opportunity. Below is a summary assembled by the Research & Innovation Office (RIO).

Program Summary

The purpose of this FOA is to support the NIGMS Human Genetic Cell Repository (HGCR). The repository will maintain the current collection of cell cultures and DNA samples and will acquire, characterize, and expand high-quality cell samples, and distribute cell lines and DNA isolated from them to qualified biomedical researchers.

It is anticipated that, in the next five-year funding period, the repository will continue to perform essentially the same functions with several additions. The additions include:

  • Sustainability planning - what are the long-term plans for achieving sustainable community access to the HGCR?  Sustainability in the context of this resource refers to continuing, long-term access to the resource.
  • Outreach - The NIGMS HGCR is expected to serve as a resource for the biomedical research community. Beyond providing samples, the HGCR should provide leadership to the community on biobanking best practices and maintaining a connection to the global biobanking community.

The successful applicant/organization must have a demonstrated track record of running an established biobank; recognized expertise in human genetics, cell culture, growth of iPSCs, and molecular biology; and experience in managing a complex resource, including customer service and outreach.

The work to be supported by this cooperative agreement includes six separate but interrelated functions:

  1. The maintenance and distribution of the approximately 11,400 cell lines currently in the repository's collection, the acquisition of new cell samples, and the establishment and characterization of permanent cell lines from these samples.
  2. The maintenance of the current stock of DNA samples for approximately 5,800 cell lines and the preparation, storage, and distribution of purified, high-quality DNA samples from additional selected cell lines in the repository.
  3. The provision of additional genetic services and distribution of other reagents as determined by the awardee and NIGMS staff.
  4. The enhancement and maintenance of a comprehensive computerized database providing detailed information on each cell line and DNA sample, and the provision of a Web-based electronic catalog that continues, at a minimum, to list in an easily accessible format cell lines and DNA samples and as much information about them as is currently available.
  5. The publicizing of the repository's collections through dissemination of information by a variety of means, including publication of descriptions of the collections in relevant journals, paid advertisements, and other activities.
  6. The dissemination of biobanking best practices and knowledge through outreach and engagement with the global biobanking community.

Deadlines

CU Internal Deadline: 11:59pm MST June 4, 2019

Sponsor Application Deadline: 3:00pm MT July 9, 2019

Internal Application Requirements (all in PDF format)

  • Project Summary (3 pages maximum): Please include the following: project site location(s), key personnel, specific aims (how the proposed work will meet the overall scientific goals of the program as well as expected outcomes and impact), research strategy (description of proposed repository and its organizational structure with milestones, experience in operating a biobank, cost recovery program, and outreach plans).
  • PI Biographical Sketch
  • Budget Overview (1 page maximum): A basic budget outlining project costs is sufficient; detailed OCG budgets are not required.

To access the online application, visit: https://colorado.secure-platform.com/a/solicitations/home/6372

Eligibility

There are no special eligibility requirements.

Limited Submission Guidelines

Only one application per institution is allowed.

Award Information

Award Amount: $2,000,000

Expected Number of Awards: 1

Award Duration: Up to 5 years