Program Summary 

The NIEHS Environmental Health Sciences Core Centers (EHS CC) Program is intended to bring together investigators currently funded by NIH or other Federal or non-Federal sources to enhance the effectiveness of existing research and extend the focus of research for the environmental health sciences. An EHS CC should support innovation and be on the cutting edge of science.  It is expected that research activities will cross a variety of disciplines to bring multiple perspectives and approaches to bear on significant problems. It is expected that the interdisciplinary nature of an EHS CC will have a synergistic effect that results in greater depth, breadth, quality, innovation and productivity beyond what individual scientists would be likely to attain by working independently. As intellectual hubs for environmental health research, the membership of EHS CC's is expected to be the thought leaders for the field as well as advance the goals of the NIEHS Strategic Plan (

The overall goals for the EHS CC Program are to enhance the capabilities of existing programs in environmental health sciences, assist with building programmatic and scientific capacity, lead in the development of novel research directions, recruit and groom future leaders in the field, and pioneer efforts in community engagement. The EHS CC grant provides facilities and resources to accelerate research along the spectrum from basic mechanistic and toxicological science to population and public health and dissemination. It should create a structure and flexibility that allow center members with different expertise to come together to answer complex and/or emerging questions and capitalize on the latest scientific trends leading to improved strategies towards preventing environmentally-induced disorders. While the EHS CC grant provides support for core resources and facilities, it does not provide direct funding for research projects, although limited funds are provided for pilot projects.

NIEHS considers community engagement and multi-directional communication as essential activities to advance the goals and relevance of an EHS CC. Therefore, the structure of the Center should facilitate multi-directional interaction with communities and EHS CC members through the required Community Engagement Core.  In addition, EHS Cores are expected to attract established and promising investigators into environmental health research and provide opportunities for career enhancement.

To qualify for an EHS CC, the applicant institution must have a base of ongoing, independently supported, peer-reviewed research projects clearly dedicated to the study of environmental health sciences or environmental medicine, a substantial portion of which should be supported by NIEHS.  The research base must exist prior to the submission of an application and will be considered by program staff to determine eligibility.  See Section III.1 Eligible Applicants for more detailed description of EHS base support calculation.


Internal Expression of Interest Deadline: N/A; email if interested

NIH Letter of Intent Deadline: March 17, 2018 (Optional)

Application Due Date: 5:00pm MST April 17, 2018


Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the SF424 (R&R) Application Guide.

Limited Submission Guidelines

Only one application per institution.

Award Information and Duration

The NIEHS intends to fund an estimate of 3-4 awards, corresponding to a total of $6.0M, for fiscal years 2019 and 2020.

Application budgets are limited to $0.7M, $1.0M or $1.3M Direct Costs per year as determined by direct costs of NIH research grants that are relevant to the environmental health sciences and for which an EHS CC member is designated as the PD/PI. See the Budget instructions for the Administrative Core to determine the applicable direct cost limit for the application.

The project period if limited to 5 years.

Funding Restrictions

NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this FOA.