NIH Collaborative Program Grant for Multidisciplinary Teams (RM1) (Clinical Trial Optional)

Below is a summary assembled by the Research & Innovation Office (RIO). Please see the full solicitation for complete information about the funding opportunity. Applicants for the internal competition should contact NIGMS to vet their idea before submitting internally.

Program Summary 

This funding opportunity announcement (FOA) is designed to support highly integrated research teams of three to six PDs/PIs to address ambitious and challenging research questions that are important for the mission of NIGMS and are beyond the scope of one or two investigators. Collaborative program teams are expected to accomplish goals that require considerable synergy and managed team interactions. Project goals should not be achievable with a collection of individual efforts or projects. Teams are encouraged to consider far-reaching objectives that will produce major advances in their fields.

Applications that are mainly focused on the creation, expansion, and/or maintenance of community resources, creation of new technologies, or infrastructure development are not appropriate for this FOA.


CU Internal Deadline: 11:59pm MT October 10, 2022

Sponsor Letter of Intent Deadline: 5:00pm MT December 27, 2022

Sponsor Application Deadline: 5:00pm MT January 27, 2023

Internal Application Requirements (all in PDF format)

  • Research Program (2 pages maximum): Proposed research should be presented as an integrated scientific program with a single set of specific aims organized to address the overall objectives rather than individual PD/PI contributions. The applicant should fully describe the biomedical problem being addressed, its significance within the relevant scientific field(s) and how successful accomplishment of the goals will provide substantial scientific advances.
  • Team Management Plan (1 page maximum): Overall team management plan that addresses how the entire group will function to accomplish program objectives and vision (e.g., the appropriate organizational structure and team composition; shared leadership, contributions and distributed responsibility for decision making; resource allocation; plans for professional development; and conflict resolution).
  • Budget Overview (1 page maximum): A basic budget outlining project costs is sufficient; detailed OCG budgets are not required.
  • NIGMS Certification: Previous applicants to this program have advised RIO that projects were not deemed a "fit" by NIGMS. It's important to contact NIGMS before submitting your internal proposal and have your concept vetted.

To access the online application, visit:


The application is required to be submitted as a multiple PD/PI application, with a minimum of 3 and a maximum of 6 PDs/PIs, all of whom must have an appointment at a domestic institution.

PD(s)/PI(s) who have an active NIGMS R35 award can participate as a PD/PI as part of the 51% effort on their current R35 award but may not receive additional funds from this award. Applicants with substantial unrestricted research support may receive funding from this award as their one NIGMS grant award, or may participate in an unfunded advisory or consulting role without loss of their ability to receive one funded NIGMS grant, consistent with NIGMS policies.

Limited Submission Guidelines

Only one application per institution is allowed per review round.

Award Information and Duration

While applications may request research program budgets of up to $1.5 million direct costs per year, it is anticipated that most awards will be between $700,000-$900,000 direct costs. Annual inflationary increases are not allowed. The requested budget should be consistent with the number of PDs/PIs and the complexity and needs of the proposed program. An additional $250,000 direct costs per year may be requested for optional developmental funds to support the addition of ESIs to the program in YRS 2-5.

Number of Awards: NIGMS anticipates supporting no more than 4-6 awards.

Award Term: Up to 5 years

Review Criteria

Please consider NIH’s specific review criteria as the proposal is developed. The internal review committee will use these criteria as a guide when evaluating internal proposals.