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Charles Hoeffer

Associate Professor

Institute for Behavioral Genetics • Integrative Physiology

Charles.Hoeffer@colorado.edu

303-492-9563

Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447

Research Interests:

Understanding the cellular and molecular basis for neurological disorder and neurodegenerative disease.

Active Grants:

NIA R01 AG064465-01 (MPI: Hoeffer, Link, Opp) 7/1/2019-6/30/2024. Sleep Disruption and Alzheimer's Disease Pathology. Role: PI
NIA R01 AG064465-01 SUPPLEMENT2 (MPI: Hoeffer, Link, Opp) 8/1/2022-7/31/2024. Sleep Disruption and Alzheimer's Disease Pathology/ Links between AD, DS and sleep disruption. Role: PI
AB Nexus Grant (MPI: Huntsman, Hoeffer) Period 12/1/2021-11/30/2022 Understanding AKT1 function regulating interneuronal activity involved in E/I balance. Role: PI

Additional Resources:

Watch Dr. Hoeffer speak

Dr. Hoeffer speaks on Molecular Signaling and Neurological Disorders:

Current Lab

Mina Griffioen

Predoctoral Trainee

Institute for Behavioral Genetics

Jessica Hanson

Postdoctoral Trainee

Institute for Behavioral Genetics

Alanna Mayberry

Predoctoral Trainee

Institute for Behavioral Genetics

Ryan Milstead

Temporary Researcher

Institute of Behavioral Science • Institute for Behavioral Genetics

Former Trainees

Helen Wong

2017

Daniel Peterson

2016

Josien Levenga

2011

Kiriana Cowansage

2011

Publications

RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging

CU Boulder Authors: Hoeffer, Charles Albert; Stitzel, Jerry A

All Authors: Wong H; Buck JM; Borski C; Pafford JT; Keller BN; Milstead RA; Hanson JL; Stitzel JA; Hoeffer CA

Published in: Journal of Neurodevelopmental Disorders
Publication Date: 2022-12-01
Type: Journal Article

TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Milstead RA; Link CD; Xu Z; Hoeffer CA

Published in: Cerebral Cortex
Publication Date: 2022-11-28
Type: Journal Article

Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Sharma S; Borski C; Hanson J; Garcia MA; Link CD; Hoeffer C; Chatterjee A; Nagpal P

Published in: ACS Chemical Neuroscience
Publication Date: 2022-11-21
Type: Journal Article

Diazepam effects on anxiety-related defensive behavior of High and Low open-field activity inbred mouse strains

CU Boulder Authors: Hoeffer, Charles Albert; Lowry, Christopher A.

All Authors: Mehrhoff EA; Booher WC; Hutchinson J; Schumacher G; Lowry C; Borski C; Hoeffer C; Ehringer M

Publication Date: 2022-05-24
Type: Conference Proceeding

Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use

CU Boulder Authors: Ehringer, Marissa A; Hoeffer, Charles Albert; Evans, Luke M.; Friedman, Naomi P

All Authors: Colbert SMC; Funkhouser SA; Johnson EC; Morrison CL; Hoeffer CA; Friedman NP; Ehringer MA; Evans LM

Published in: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Publication Date: 2021-09-27
Type: Journal Article

Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory formation

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Gindina S; Botsford B; Cowansage K; LeDoux J; Klann E; Hoeffer C; Ostroff L

Published in: Journal of Comparative Neurology
Publication Date: 2021-04-27
Type: Journal Article

Immunohistological Examination of AKT Isoforms in the Brain: Cell-Type Specificity That May Underlie AKT’s Role in Complex Brain Disorders and Neurological Disease

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Levenga J; Wong H; Milstead R; LaPlante L; Hoeffer CA

Publication Date: 2021-04-01
Type: Journal Article

Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders

CU Boulder Authors: Hoeffer, Charles Albert; Ehringer, Marissa A

All Authors:

Wong H; Levenga J; LaPlante L; Keller B; Cooper-Sansone A; Borski C; Milstead R; Ehringer M; Hoeffer C...

Wong H
Levenga J
LaPlante L
Keller B
Cooper-Sansone A
Borski C
Milstead R
Ehringer M
Hoeffer C

Published in: eLife
Publication Date: 2020-12-16
Type: Journal Article

The Role of A Priori-Identified Addiction and Smoking Gene Sets in Smoking Behaviors

CU Boulder Authors: Keller, Matthew C; Hoeffer, Charles Albert; Evans, Luke M.; Hewitt, John K; Stitzel, Jerry A; Ehringer, Marissa A

All Authors:

Evans LM; Johnson EC; Melroy-Greif WE; Hewitt JK; Hoeffer CA; Keller MC; Saba LM; Stitzel JA; Ehringer MA...

Evans LM
Johnson EC
Melroy-Greif WE
Hewitt JK
Hoeffer CA
Keller MC
Saba LM
Stitzel JA
Ehringer MA

Published in: Nicotine and Tobacco Research
Publication Date: 2020-08-01
Type: Journal Article

Sleep Behavior and EEG Oscillations in Aged Dp(16)1Yey/+ Mice: A Down Syndrome Model

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Levenga J; Peterson DJ; Cain P; Hoeffer CA

Published in: Neuroscience
Publication Date: 2018-04-15
Type: Journal Article

Maternal IL-17A in autism

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Wong H; Hoeffer C

Published in: Experimental Neurology
Publication Date: 2018-01-01
Type: Journal Article

AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Levenga J; Wong H; Milstead RA; Keller BN; LaPlante L; Hoeffer CA

Published in: eLife
Publication Date: 2017-11-27
Type: Journal Article

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

CU Boulder Authors: Hoeffer, Charles Albert; Stitzel, Jerry A

All Authors:

Koukouli F; Rooy M; Tziotis D; Sailor KA; O'Neill HC; Levenga J; Witte M; Nilges M; Changeux J-P; Hoeffer CA...

Koukouli F
Rooy M
Tziotis D
Sailor KA
O'Neill HC
Levenga J
Witte M
Nilges M
Changeux J-P
Hoeffer CA

Published in: Nature Medicine
Publication Date: 2017-03-01
Type: Journal Article

Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Ostroff LE; Botsford B; Gindina S; Cowansage KK; LeDoux JE; Klann E; Hoeffer C

Published in: The Journal of Neuroscience
Publication Date: 2017-02-15
Type: Journal Article

RNA and Protein Targets of FMRP

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Suhl J; Hoeffer C

Publication Date: 2017-01-01
Type: Chapter

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy

CU Boulder Authors: Hoeffer, Charles Albert

All Authors:

Congdon EE; Lin Y; Rajamohamedsait HB; Shamir DB; Krishnaswamy S; Rajamohamedsait WJ; Rasool S; Gonzalez V; Levenga J; G...

Congdon EE
Lin Y
Rajamohamedsait HB
Shamir DB
Krishnaswamy S
Rajamohamedsait WJ
Rasool S
Gonzalez V
Levenga J
Gu J

Published in: Molecular Neurodegeneration
Publication Date: 2016-08-30
Type: Journal Article

Translational Regulation of Synaptic Plasticity

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: HOEFFER CA; Santini E; Klann E

Publication Date: 2016-08-23
Type: Chapter

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Choi GB; Yim YS; Wong H; Kim S; Kim H; Kim SV; Hoeffer CA; Littman DR; Huh JR

Published in: Science
Publication Date: 2016-02-26
Type: Journal Article

RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Wong H; Levenga J; Cain P; Rothermel B; Klann E; Hoeffer C

Published in: Acta Neuropathologica
Publication Date: 2015-12-01
Type: Journal Article

cGMP-dependent protein kinase type II knockout mice exhibit working memory impairments, decreased repetitive behavior, and increased anxiety-like traits

CU Boulder Authors: Hoeffer, Charles Albert

All Authors:

Wincott CM; Abera S; Vunck SA; Tirko N; Choi Y; Titcombe RF; Antoine SO; Tukey DS; DeVito LM; Hofmann F...

Wincott CM
Abera S
Vunck SA
Tirko N
Choi Y
Titcombe RF
Antoine SO
Tukey DS
DeVito LM
Hofmann F

Published in: Neurobiology of Learning and Memory
Publication Date: 2014-10-01
Type: Journal Article

Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission.

CU Boulder Authors: Hoeffer, Charles Albert

All Authors:

Karayannis T; Au E; Patel JC; Kruglikov I; Markx S; Delorme R; Héron D; Salomon D; Glessner J; Restituito S...

Karayannis T
Au E
Patel JC
Kruglikov I
Markx S
Delorme R
Héron D
Salomon D
Glessner J
Restituito S

Published in: Nature
Publication Date: 2014-07-01
Type: Journal Article

The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression.

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Trinh MA; Ma T; Kaphzan H; Bhattacharya A; Antion MD; Cavener DR; Hoeffer CA; Klann E

Published in: Learning and Memory
Publication Date: 2014-05-01
Type: Journal Article

Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexity.

CU Boulder Authors: Hoeffer, Charles Albert

All Authors:

Bowling H; Zhang G; Bhattacharya A; Pérez-Cuesta LM; Deinhardt K; Hoeffer CA; Neubert TA; Gan WB; Klann E; Chao MV...

Bowling H
Zhang G
Bhattacharya A
Pérez-Cuesta LM
Deinhardt K
Hoeffer CA
Neubert TA
Gan WB
Klann E
Chao MV

Published in: Science Signaling
Publication Date: 2014-01-01
Type: Journal Article

Regulator of calcineurin 1 modulates expression of innate anxiety and anxiogenic responses to selective serotonin reuptake inhibitor treatment.

CU Boulder Authors: Hoeffer, Charles Albert

All Authors:

Hoeffer CA; Wong H; Cain P; Levenga J; Cowansage KK; Choi Y; Davy C; Majmundar N; McMillan DR; Rothermel BA...

Hoeffer CA
Wong H
Cain P
Levenga J
Cowansage KK
Choi Y
Davy C
Majmundar N
McMillan DR
Rothermel BA

Published in: The Journal of Neuroscience
Publication Date: 2013-10-01
Type: Journal Article

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments.

CU Boulder Authors: Hoeffer, Charles Albert

All Authors: Levenga J; Krishnamurthy P; Rajamohamedsait H; Wong H; Franke TF; Cain P; Sigurdsson EM; Hoeffer CA

Published in: Acta Neuropathologica Communications
Publication Date: 2013-01-01
Type: Journal Article

Recruiting

The Hoeffer Lab is interested in accepting graduate students. Prospective students should review the program requirements and contact Dr. Hoeffer directly.

Highlighted Publications

AKT isoform expression in response to genetic deletion of the other two isoforms. (A) Western blot analysis of AKT isoform levels in hippocampal lysates prepared from Akt mutant mice.

Immunohistological Examination of AKT Isoforms in the Brain: Cell-Type Specificity That May Underlie AKT’s Role in Complex Brain Disorders and Neurological Disease

In this study, we use a combination of histology, immunostaining, and genetics to characterize cell-type-specific expression of AKT isoforms in human and mouse brains. In mice, we find that AKT1 is the most broadly expressed isoform, with expression in excitatory neurons and the sole detectable AKT isoform in gamma-aminobutyric acid ergic interneurons and microglia. By contrast, we find that AKT2 is the sole isoform expressed in astroglia and is not detected in other neural cell types. Because AKT signaling is linked to numerous neurological disorders, a greater understanding of cell-specific isoform expression could improve treatment strategies involving AKT.

(Cerebral Cortex Communications, 2021)

Restoration of AKT1 expression in the PFC normalizes extinction learning and LTM in Akt1 KO males

Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders

Our studies revealed AKT isoform- and sex-specific effects on anxiety, spatial and contextual memory, and fear extinction. These results highlight sex as a biological variable and isoform- or cell type-specific AKT signaling as potential targets for improving treatment of neuropsychiatric disorders.

(eLife, 2020)

Dp16 mice show disturbed sleep pattern measured in number of transitions and average bout lengths.

Sleep Behavior and EEG Oscillations in Aged Dp(16)1Yey/+ Mice: A Down Syndrome Model

In this study, sleep and electroencephalography (EEG) oscillations were recorded from aged Dp(16)1Yey/+ mice (Dp16), a mouse model of DS. We observed disrupted sleep demonstrated by increased activity during the dark phase and increased time awake at the expense of NREM sleep compared to wild-type mice. These results in Dp16 mice are consistent with sleep disturbances found in individuals with DS, and the abnormal EEG oscillations in aged Dp16 mice suggest a potential role for GABAergic activity in these sleep and EEG abnormalities.

(Neuroscience, 2018)

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Research from IBG offers new insights into biology of response to treatment of psychiatric disorders

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People at IBG

Charles Hoeffer

Research Interests:

Active Grants:

Additional Resources:

Current Lab

Former Trainees

Helen Wong

Daniel Peterson

Josien Levenga

Kiriana Cowansage

Publications

Diazepam effects on anxiety-related defensive behavior of High and Low open-field activity inbred mouse strains

Translational Regulation of Synaptic Plasticity

Pages

Recruiting

Highlighted Publications

News