
Associate Professor
Institute for Behavioral Genetics • Integrative Physiology
Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447
Research Interests:
Understanding the cellular and molecular basis for neurological disorder and neurodegenerative disease.
Active Grants:
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NIA R01 AG064465-01 (MPI: Hoeffer, Link, Opp) 7/1/2019-6/30/2024. Sleep Disruption and Alzheimer's Disease Pathology. Role: PI
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NIA R01 AG064465-01 SUPPLEMENT2 (MPI: Hoeffer, Link, Opp) 8/1/2022-7/31/2024. Sleep Disruption and Alzheimer's Disease Pathology/ Links between AD, DS and sleep disruption. Role: PI
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AB Nexus Grant (MPI: Huntsman, Hoeffer) Period 12/1/2021-11/30/2022 Understanding AKT1 function regulating interneuronal activity involved in E/I balance. Role: PI
Additional Resources:
Dr. Hoeffer speaks on Molecular Signaling and Neurological Disorders:
Current Lab

Mina Griffioen
Predoctoral Trainee
Institute for Behavioral Genetics

Jessica Hanson
Postdoctoral Trainee
Institute for Behavioral Genetics

Alanna Mayberry
Predoctoral Trainee
Institute for Behavioral Genetics

Ryan Milstead
Temporary Researcher
Institute of Behavioral Science • Institute for Behavioral Genetics
Former Trainees
Helen Wong
2017
Daniel Peterson
2016
Josien Levenga
2011
Kiriana Cowansage
2011
Publications
RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging
CU Boulder Authors:
Hoeffer, Charles Albert; Stitzel, Jerry A
All Authors:
Wong H; Buck JM; Borski C; Pafford JT; Keller BN; Milstead RA; Hanson JL; Stitzel JA; Hoeffer CA
Published in: Journal of Neurodevelopmental DisordersPublication Date: 2022-12-01
Type: Journal Article
TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Milstead RA; Link CD; Xu Z; Hoeffer CA
Published in: Cerebral CortexPublication Date: 2022-11-28
Type: Journal Article
Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Sharma S; Borski C; Hanson J; Garcia MA; Link CD; Hoeffer C; Chatterjee A; Nagpal P
Published in: ACS Chemical NeurosciencePublication Date: 2022-11-21
Type: Journal Article
Diazepam effects on anxiety-related defensive behavior of High and Low open-field activity inbred mouse strains
CU Boulder Authors:
Hoeffer, Charles Albert; Lowry, Christopher A.
All Authors:
Mehrhoff EA; Booher WC; Hutchinson J; Schumacher G; Lowry C; Borski C; Hoeffer C; Ehringer M
Publication Date: 2022-05-24Type: Conference Proceeding
Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use
All Authors:
Colbert SMC; Funkhouser SA; Johnson EC; Morrison CL; Hoeffer CA; Friedman NP; Ehringer MA; Evans LM
Published in: American Journal of Medical Genetics Part B: Neuropsychiatric GeneticsPublication Date: 2021-09-27
Type: Journal Article
Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory formation
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Gindina S; Botsford B; Cowansage K; LeDoux J; Klann E; Hoeffer C; Ostroff L
Published in: Journal of Comparative NeurologyPublication Date: 2021-04-27
Type: Journal Article
Immunohistological Examination of AKT Isoforms in the Brain: Cell-Type Specificity That May Underlie AKT’s Role in Complex Brain Disorders and Neurological Disease
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Levenga J; Wong H; Milstead R; LaPlante L; Hoeffer CA
Publication Date: 2021-04-01Type: Journal Article
Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders
CU Boulder Authors:
Hoeffer, Charles Albert; Ehringer, Marissa A
All Authors:
Published in: eLifeWong H; Levenga J; LaPlante L; Keller B; Cooper-Sansone A; Borski C; Milstead R; Ehringer M; Hoeffer C...
- Wong H
- Levenga J
- LaPlante L
- Keller B
- Cooper-Sansone A
- Borski C
- Milstead R
- Ehringer M
- Hoeffer C
Publication Date: 2020-12-16
Type: Journal Article
The Role of A Priori-Identified Addiction and Smoking Gene Sets in Smoking Behaviors
CU Boulder Authors:
Keller, Matthew C; Hoeffer, Charles Albert; Evans, Luke M.; Hewitt, John K; Stitzel, Jerry A; Ehringer, Marissa A
All Authors:
Published in: Nicotine and Tobacco ResearchEvans LM; Johnson EC; Melroy-Greif WE; Hewitt JK; Hoeffer CA; Keller MC; Saba LM; Stitzel JA; Ehringer MA...
- Evans LM
- Johnson EC
- Melroy-Greif WE
- Hewitt JK
- Hoeffer CA
- Keller MC
- Saba LM
- Stitzel JA
- Ehringer MA
Publication Date: 2020-08-01
Type: Journal Article
Sleep Behavior and EEG Oscillations in Aged Dp(16)1Yey/+ Mice: A Down Syndrome Model
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Levenga J; Peterson DJ; Cain P; Hoeffer CA
Published in: NeurosciencePublication Date: 2018-04-15
Type: Journal Article
Maternal IL-17A in autism
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Wong H; Hoeffer C
Published in: Experimental NeurologyPublication Date: 2018-01-01
Type: Journal Article
AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Levenga J; Wong H; Milstead RA; Keller BN; LaPlante L; Hoeffer CA
Published in: eLifePublication Date: 2017-11-27
Type: Journal Article
Nicotine reverses hypofrontality in animal models of addiction and schizophrenia
CU Boulder Authors:
Hoeffer, Charles Albert; Stitzel, Jerry A
All Authors:
Published in: Nature MedicineKoukouli F; Rooy M; Tziotis D; Sailor KA; O'Neill HC; Levenga J; Witte M; Nilges M; Changeux J-P; Hoeffer CA...
- Koukouli F
- Rooy M
- Tziotis D
- Sailor KA
- O'Neill HC
- Levenga J
- Witte M
- Nilges M
- Changeux J-P
- Hoeffer CA
Publication Date: 2017-03-01
Type: Journal Article
Accumulation of Polyribosomes in Dendritic Spine Heads, But Not Bases and Necks, during Memory Consolidation Depends on Cap-Dependent Translation Initiation
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Ostroff LE; Botsford B; Gindina S; Cowansage KK; LeDoux JE; Klann E; Hoeffer C
Published in: The Journal of NeurosciencePublication Date: 2017-02-15
Type: Journal Article
RNA and Protein Targets of FMRP
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Suhl J; Hoeffer C
Publication Date: 2017-01-01Type: Chapter
Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Published in: Molecular NeurodegenerationCongdon EE; Lin Y; Rajamohamedsait HB; Shamir DB; Krishnaswamy S; Rajamohamedsait WJ; Rasool S; Gonzalez V; Levenga J; G...
- Congdon EE
- Lin Y
- Rajamohamedsait HB
- Shamir DB
- Krishnaswamy S
- Rajamohamedsait WJ
- Rasool S
- Gonzalez V
- Levenga J
- Gu J
Publication Date: 2016-08-30
Type: Journal Article
Translational Regulation of Synaptic Plasticity
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
HOEFFER CA; Santini E; Klann E
Publication Date: 2016-08-23Type: Chapter
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Choi GB; Yim YS; Wong H; Kim S; Kim H; Kim SV; Hoeffer CA; Littman DR; Huh JR
Published in: SciencePublication Date: 2016-02-26
Type: Journal Article
RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Wong H; Levenga J; Cain P; Rothermel B; Klann E; Hoeffer C
Published in: Acta NeuropathologicaPublication Date: 2015-12-01
Type: Journal Article
cGMP-dependent protein kinase type II knockout mice exhibit working memory impairments, decreased repetitive behavior, and increased anxiety-like traits
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Published in: Neurobiology of Learning and MemoryWincott CM; Abera S; Vunck SA; Tirko N; Choi Y; Titcombe RF; Antoine SO; Tukey DS; DeVito LM; Hofmann F...
- Wincott CM
- Abera S
- Vunck SA
- Tirko N
- Choi Y
- Titcombe RF
- Antoine SO
- Tukey DS
- DeVito LM
- Hofmann F
Publication Date: 2014-10-01
Type: Journal Article
Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission.
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Published in: NatureKarayannis T; Au E; Patel JC; Kruglikov I; Markx S; Delorme R; Héron D; Salomon D; Glessner J; Restituito S...
- Karayannis T
- Au E
- Patel JC
- Kruglikov I
- Markx S
- Delorme R
- Héron D
- Salomon D
- Glessner J
- Restituito S
Publication Date: 2014-07-01
Type: Journal Article
The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression.
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Trinh MA; Ma T; Kaphzan H; Bhattacharya A; Antion MD; Cavener DR; Hoeffer CA; Klann E
Published in: Learning and MemoryPublication Date: 2014-05-01
Type: Journal Article
Antipsychotics activate mTORC1-dependent translation to enhance neuronal morphological complexity.
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Published in: Science SignalingBowling H; Zhang G; Bhattacharya A; Pérez-Cuesta LM; Deinhardt K; Hoeffer CA; Neubert TA; Gan WB; Klann E; Chao MV...
- Bowling H
- Zhang G
- Bhattacharya A
- Pérez-Cuesta LM
- Deinhardt K
- Hoeffer CA
- Neubert TA
- Gan WB
- Klann E
- Chao MV
Publication Date: 2014-01-01
Type: Journal Article
Regulator of calcineurin 1 modulates expression of innate anxiety and anxiogenic responses to selective serotonin reuptake inhibitor treatment.
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Published in: The Journal of NeuroscienceHoeffer CA; Wong H; Cain P; Levenga J; Cowansage KK; Choi Y; Davy C; Majmundar N; McMillan DR; Rothermel BA...
- Hoeffer CA
- Wong H
- Cain P
- Levenga J
- Cowansage KK
- Choi Y
- Davy C
- Majmundar N
- McMillan DR
- Rothermel BA
Publication Date: 2013-10-01
Type: Journal Article
Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments.
CU Boulder Authors:
Hoeffer, Charles Albert
All Authors:
Levenga J; Krishnamurthy P; Rajamohamedsait H; Wong H; Franke TF; Cain P; Sigurdsson EM; Hoeffer CA
Published in: Acta Neuropathologica CommunicationsPublication Date: 2013-01-01
Type: Journal Article
Pages
Recruiting
The Hoeffer Lab is interested in accepting graduate students. Prospective students should review the program requirements and contact Dr. Hoeffer directly.