
Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447
Research Interests:
Developing models to understand complex trait genetics. Using family-based GWAS datasets to estimate direct genetic effects and the environmental influences of parents on offspring. Modeling and simulating genetically informative designs that better enable us to understand the causes of human differences.
Active Grants:
- NIMH R01 MH130448 7/2022-6/2027 Causes and consequences of mental disorders: The environmental and genetic influences of parents on offspring. Role: Principal investigator
- NIMH 2R01 MH100141 2/2013-4/2023 Estimating the genetic and environmental architecture of psychiatric disorders. Role: Principal investigator
- NIMH R25 MH019918 2/2024-1/2029 Workshop on statistical genetic methods for human complex traits. Role: Principal investigator
- NIDA R01 DA054087 5/1/2022 – 4/30/2027 Understanding the links between parental and adolescent substance use: complementary natural experiments using the children of twins design. Role: Co-Principal investigator
- NIDA R01 DA046064 4/2018-1/2023 Brain and genetic predictors of individual differences in pain and placebo analgesia. Role: Co-investigator
- NIDA R01 DA044283 5/2019 – 2/2024 Deep sequencing, phenotyping, and imputation in large-scale biobanks: A novel and cost-effective framework to identify rare mutations associated with addiction. Role: Principal investigator of subcontract
- NIDA R01 DA053693 4/2024 – 3/2028 Adult Progression of Adolescent Onset Substance Use Disorder in a High Risk Sample. Role: Co-investigator
Additional Resources:
Current Lab






Former Trainees
Spencer Moore
Masters student
2020-2022
Jared Balbona
Doctoral student
2018-2022
Richard Border
Doctoral student
2014-2019
Emma Johnson
Doctoral student
2012-2017
Teresa de Candia
Doctoral student
2011-2015
Matthew Simonson
Doctoral student
2008-2013
Dan Howrigan
Doctoral student
2008-2012
Laramie Duncan
Doctoral student
2008-2010
Subrata Paul
Postdoctoral trainee
2020-2021
Meng Huang
Postdoctoral trainee
2020-2021
Rasool Tahmasbi
Postdoctoral trainee
2015-2018
Luke Evans
Postdoctoral trainee
2015-2018
Doug Bjelland
Postdoctoral trainee
2013-2016
Christine Garver-Apgar
Postdoctoral trainee
2008-2011
Meta-analysis of genome-wide association studies of anxiety disorders
Publication Date: 2016-10-01
Type: Journal Article
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
Johnson EC; Bjelland DW; Howrigan DP; Abdellaoui A; Breen G; Borglum A; Cichon S; Degenhardt F; Forstner AJ; Frank J...
- Johnson EC
- Bjelland DW
- Howrigan DP
- Abdellaoui A
- Breen G
- Borglum A
- Cichon S
- Degenhardt F
- Forstner AJ
- Frank J
Publication Date: 2016-10-01
Type: Journal Article
Evidence of Shared Genome-Wide Additive Genetic Effects on Interpersonal Trauma Exposure and Generalized Vulnerability to Drug Dependence in a Population of Substance Users
Publication Date: 2016-06-01
Type: Journal Article
Genome-wide autozygosity is associated with lower general cognitive ability
Howrigan DP; Simonson MA; Davies G; Harris SE; Tenesa A; Starr JM; Liewald DC; Deary IJ; McRae A; Wright MJ...
- Howrigan DP
- Simonson MA
- Davies G
- Harris SE
- Tenesa A
- Starr JM
- Liewald DC
- Deary IJ
- McRae A
- Wright MJ
Publication Date: 2016-06-01
Type: Journal Article
Facial averageness and genetic quality: testing heritability, genetic correlation with attractiveness, and the paternal age effect
Publication Date: 2016-01-01
Type: Journal Article
Shared additive genetic influences on DSM-IV criteria for alcohol dependence in subjects of European ancestry
Publication Date: 2015-12-01
Type: Journal Article
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index
Yang J; Bakshi A; Zhu Z; Hemani G; Vinkhuyzen AAE; Lee SH; Robinson MR; Perry JRB; Nolte IM; van Vliet-Ostaptchouk JV...
- Yang J
- Bakshi A
- Zhu Z
- Hemani G
- Vinkhuyzen AAE
- Lee SH
- Robinson MR
- Perry JRB
- Nolte IM
- van Vliet-Ostaptchouk JV
Publication Date: 2015-10-01
Type: Journal Article
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.
Lee SH; Byrne EM; Hultman CM; Kähler A; Vinkhuyzen AAE; Ripke S; Andreassen OA; Frisell T; Gusev A; Hu X...
- Lee SH
- Byrne EM
- Hultman CM
- Kähler A
- Vinkhuyzen AAE
- Ripke S
- Andreassen OA
- Frisell T
- Gusev A
- Hu X
Publication Date: 2015-10-01
Type: Journal Article
A test of the facultative calibration/reactive heritability model of extraversion
Publication Date: 2015-09-01
Type: Journal Article
Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment
Trampush JW; Lencz T; Knowles E; Davies G; Guha S; Pe'er I; Liewald DC; Starr JM; Djurovic S; Melle I...
- Trampush JW
- Lencz T
- Knowles E
- Davies G
- Guha S
- Pe'er I
- Liewald DC
- Starr JM
- Djurovic S
- Melle I
Publication Date: 2015-07-01
Type: Journal Article
Genetic variation links creativity to psychiatric disorders
Publication Date: 2015-07-01
Type: Journal Article
Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample
Derringer J; Corley RP; Haberstick BC; Young SE; Demmitt BA; Howrigan DP; Kirkpatrick RM; Iacono WG; McGue M; Keller MC...
- Derringer J
- Corley RP
- Haberstick BC
- Young SE
- Demmitt BA
- Howrigan DP
- Kirkpatrick RM
- Iacono WG
- McGue M
- Keller MC
Publication Date: 2015-07-01
Type: Journal Article
No relationship between intelligence and facial attractiveness in a large, genetically informative sample
Publication Date: 2015-05-01
Type: Journal Article
Evolutionary behavioral genetics
Publication Date: 2015-04-01
Type: Journal Article
Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence
Publication Date: 2015-03-01
Type: Journal Article
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
O'Dushlaine C; Rossin L; Lee PH; Duncan L; Parikshak NN; Newhouse S; Ripke S; Neale BM; Purcell SM; Posthuma D...
- O'Dushlaine C
- Rossin L
- Lee PH
- Duncan L
- Parikshak NN
- Newhouse S
- Ripke S
- Neale BM
- Purcell SM
- Posthuma D
Publication Date: 2015-02-01
Type: Journal Article
Candidate Gene-Environment Interaction Research: Reflections and Recommendations
Publication Date: 2015-01-01
Type: Journal Article
The Association of Genotype-Based Inbreeding Coefficient with a Range of Physical and Psychological Human Traits
Publication Date: 2014-07-25
Type: Journal Article
Biological insights from 108 schizophrenia-associated genetic loci
Ripke S; Neale BM; Corvin A; Walters JTR; Farh K-H; Holmans PA; Lee P; Bulik-Sullivan B; Collier DA; Huang H...
- Ripke S
- Neale BM
- Corvin A
- Walters JTR
- Farh K-H
- Holmans PA
- Lee P
- Bulik-Sullivan B
- Collier DA
- Huang H
Publication Date: 2014-07-24
Type: Journal Article
Large-scale genomics unveils the genetic architecture of psychiatric disorders
Publication Date: 2014-06-01
Type: Journal Article
Estimating the Sex-Specific Effects of Genes on Facial Attractiveness and Sexual Dimorphism
Mitchem DG; Purkey AM; Grebe NM; Carey G; Garver-Apgar CE; Bates TC; Arden R; Hewitt JK; Medland SE; Martin NG...
- Mitchem DG
- Purkey AM
- Grebe NM
- Carey G
- Garver-Apgar CE
- Bates TC
- Arden R
- Hewitt JK
- Medland SE
- Martin NG
Publication Date: 2014-05-01
Type: Journal Article
Estimating the Sex-Specific Effects of Genes on Facial Attractiveness and Sexual Dimorphism
Mitchem DG; Purkey AM; Grebe NM; Carey G; Garver-Apgar CE; Bates TC; Arden R; Hewitt JK; Medland SE; Martin NG...
- Mitchem DG
- Purkey AM
- Grebe NM
- Carey G
- Garver-Apgar CE
- Bates TC
- Arden R
- Hewitt JK
- Medland SE
- Martin NG
Publication Date: 2014-05-01
Type: Conference Proceeding
A Recessive Genetic Model and Runs of Homozygosity in Major Depressive Disorder
Publication Date: 2014-03-01
Type: Journal Article
Genetic Factors That Increase Male Facial Masculinity Decrease Facial Attractiveness of Female Relatives
Publication Date: 2014-02-01
Type: Journal Article
Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT)
Lencz T; Knowles E; Davies G; Guha S; Liewald DC; Starr JM; Djurovic S; Melle I; Sundet K; Christoforou A...
- Lencz T
- Knowles E
- Davies G
- Guha S
- Liewald DC
- Starr JM
- Djurovic S
- Melle I
- Sundet K
- Christoforou A
Publication Date: 2014-02-01
Type: Journal Article
Pages
Recruiting
The Keller lab is recruiting new graduate students.
Contact Matt Keller directly about postdoctoral trainee positions.