
Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447
Research Interests:
Developing models to understand complex trait genetics. Using family-based GWAS datasets to estimate direct genetic effects and the environmental influences of parents on offspring. Modeling and simulating genetically informative designs that better enable us to understand the causes of human differences.
Active Grants:
- NIMH R01 MH130448 7/2022-6/2027 Causes and consequences of mental disorders: The environmental and genetic influences of parents on offspring. Role: Principal investigator
- NIMH 2R01 MH100141 2/2013-4/2023 Estimating the genetic and environmental architecture of psychiatric disorders. Role: Principal investigator
- NIMH R25 MH019918 2/2024-1/2029 Workshop on statistical genetic methods for human complex traits. Role: Principal investigator
- NIDA R01 DA054087 5/1/2022 – 4/30/2027 Understanding the links between parental and adolescent substance use: complementary natural experiments using the children of twins design. Role: Co-Principal investigator
- NIDA R01 DA046064 4/2018-1/2023 Brain and genetic predictors of individual differences in pain and placebo analgesia. Role: Co-investigator
- NIDA R01 DA044283 5/2019 – 2/2024 Deep sequencing, phenotyping, and imputation in large-scale biobanks: A novel and cost-effective framework to identify rare mutations associated with addiction. Role: Principal investigator of subcontract
- NIDA R01 DA053693 4/2024 – 3/2028 Adult Progression of Adolescent Onset Substance Use Disorder in a High Risk Sample. Role: Co-investigator
Additional Resources:
Current Lab







Former Trainees
Spencer Moore
Masters student
2020-2022
Jared Balbona
Doctoral student
2018-2022
Richard Border
Doctoral student
2014-2019
Emma Johnson
Doctoral student
2012-2017
Teresa de Candia
Doctoral student
2011-2015
Matthew Simonson
Doctoral student
2008-2013
Dan Howrigan
Doctoral student
2008-2012
Laramie Duncan
Doctoral student
2008-2010
Subrata Paul
Postdoctoral trainee
2020-2021
Meng Huang
Postdoctoral trainee
2020-2021
Rasool Tahmasbi
Postdoctoral trainee
2015-2018
Luke Evans
Postdoctoral trainee
2015-2018
Doug Bjelland
Postdoctoral trainee
2013-2016
Christine Garver-Apgar
Postdoctoral trainee
2008-2011
Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets
Publication Date: 2017-11-28
Type: Journal Article
No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes
Publication Date: 2017-11-15
Type: Journal Article
Assessing the accuracy of perceptions of intelligence based on heritable facial features
Publication Date: 2017-09-01
Type: Journal Article
Genetic influences on the human oral microbiome
Demmitt BA; Corley RP; Huibregtse BM; Keller MC; Hewitt JK; McQueen MB; Knight R; McDermott I; Krauter KS...
- Demmitt BA
- Corley RP
- Huibregtse BM
- Keller MC
- Hewitt JK
- McQueen MB
- Knight R
- McDermott I
- Krauter KS
Publication Date: 2017-08-24
Type: Journal Article
A fast and accurate method for detection of IBD shared haplotypes in genome-wide SNP data
Publication Date: 2017-05-01
Type: Journal Article
Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci
Publication Date: 2017-04-01
Type: Journal Article
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
Trampush JW; Yang MLZ; Yu J; Knowles E; Davies G; Liewald DC; Starr JM; Djurovic S; Melle I; Sundet K...
- Trampush JW
- Yang MLZ
- Yu J
- Knowles E
- Davies G
- Liewald DC
- Starr JM
- Djurovic S
- Melle I
- Sundet K
Publication Date: 2017-03-01
Type: Journal Article
Commentary: Fundamental problems with candidate gene-by-environment interaction studies - reflections on Moore and Thoemmes (2016)
Publication Date: 2017-03-01
Type: Journal Article
GeneEvolve: a fast and memory efficient forward-time simulator of realistic whole-genome sequence and SNP data
Publication Date: 2017-01-15
Type: Journal Article
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Marshall CR; Howrigan DP; Merico D; Thiruvahindrapuram B; Wu W; Greer DS; Antaki D; Shetty A; Holmans PA; Pinto D...
- Marshall CR
- Howrigan DP
- Merico D
- Thiruvahindrapuram B
- Wu W
- Greer DS
- Antaki D
- Shetty A
- Holmans PA
- Pinto D
Publication Date: 2017-01-01
Type: Journal Article
Predicting Cognitive Executive Functioning with Polygenic Risk Scores for Psychiatric Disorders
Publication Date: 2017-01-01
Type: Journal Article
Meta-analysis of genome-wide association studies of anxiety disorders
Publication Date: 2016-10-01
Type: Journal Article
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
Johnson EC; Bjelland DW; Howrigan DP; Abdellaoui A; Breen G; Borglum A; Cichon S; Degenhardt F; Forstner AJ; Frank J...
- Johnson EC
- Bjelland DW
- Howrigan DP
- Abdellaoui A
- Breen G
- Borglum A
- Cichon S
- Degenhardt F
- Forstner AJ
- Frank J
Publication Date: 2016-10-01
Type: Journal Article
Evidence of Shared Genome-Wide Additive Genetic Effects on Interpersonal Trauma Exposure and Generalized Vulnerability to Drug Dependence in a Population of Substance Users
Publication Date: 2016-06-01
Type: Journal Article
Genome-wide autozygosity is associated with lower general cognitive ability
Howrigan DP; Simonson MA; Davies G; Harris SE; Tenesa A; Starr JM; Liewald DC; Deary IJ; McRae A; Wright MJ...
- Howrigan DP
- Simonson MA
- Davies G
- Harris SE
- Tenesa A
- Starr JM
- Liewald DC
- Deary IJ
- McRae A
- Wright MJ
Publication Date: 2016-06-01
Type: Journal Article
Facial averageness and genetic quality: testing heritability, genetic correlation with attractiveness, and the paternal age effect
Publication Date: 2016-01-01
Type: Journal Article
Shared additive genetic influences on DSM-IV criteria for alcohol dependence in subjects of European ancestry
Publication Date: 2015-12-01
Type: Journal Article
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index
Yang J; Bakshi A; Zhu Z; Hemani G; Vinkhuyzen AAE; Lee SH; Robinson MR; Perry JRB; Nolte IM; van Vliet-Ostaptchouk JV...
- Yang J
- Bakshi A
- Zhu Z
- Hemani G
- Vinkhuyzen AAE
- Lee SH
- Robinson MR
- Perry JRB
- Nolte IM
- van Vliet-Ostaptchouk JV
Publication Date: 2015-10-01
Type: Journal Article
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.
Lee SH; Byrne EM; Hultman CM; Kähler A; Vinkhuyzen AAE; Ripke S; Andreassen OA; Frisell T; Gusev A; Hu X...
- Lee SH
- Byrne EM
- Hultman CM
- Kähler A
- Vinkhuyzen AAE
- Ripke S
- Andreassen OA
- Frisell T
- Gusev A
- Hu X
Publication Date: 2015-10-01
Type: Journal Article
A test of the facultative calibration/reactive heritability model of extraversion
Publication Date: 2015-09-01
Type: Journal Article
Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment
Trampush JW; Lencz T; Knowles E; Davies G; Guha S; Pe'er I; Liewald DC; Starr JM; Djurovic S; Melle I...
- Trampush JW
- Lencz T
- Knowles E
- Davies G
- Guha S
- Pe'er I
- Liewald DC
- Starr JM
- Djurovic S
- Melle I
Publication Date: 2015-07-01
Type: Journal Article
Genetic variation links creativity to psychiatric disorders
Publication Date: 2015-07-01
Type: Journal Article
Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample
Derringer J; Corley RP; Haberstick BC; Young SE; Demmitt BA; Howrigan DP; Kirkpatrick RM; Iacono WG; McGue M; Keller MC...
- Derringer J
- Corley RP
- Haberstick BC
- Young SE
- Demmitt BA
- Howrigan DP
- Kirkpatrick RM
- Iacono WG
- McGue M
- Keller MC
Publication Date: 2015-07-01
Type: Journal Article
No relationship between intelligence and facial attractiveness in a large, genetically informative sample
Publication Date: 2015-05-01
Type: Journal Article
Evolutionary behavioral genetics
Publication Date: 2015-04-01
Type: Journal Article
Pages
Recruiting
The Keller lab is not currently recruiting new graduate students.
Contact Matt Keller directly about postdoctoral trainee positions.