![Matthew Keller, Professor](https://www.colorado.edu/ibg/sites/default/files/styles/small/public/people/matt_keller_a.jpg?itok=lLtJMo3r)
Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447
Research Interests:
Developing models to understand complex trait genetics. Using family-based GWAS datasets to estimate direct genetic effects and the environmental influences of parents on offspring. Modeling and simulating genetically informative designs that better enable us to understand the causes of human differences.
Active Grants:
- NIMH R01 MH130448 7/2022-6/2027 Causes and consequences of mental disorders: The environmental and genetic influences of parents on offspring. Role: Principal investigator
- NIMH 2R01 MH100141 2/2013-4/2023 Estimating the genetic and environmental architecture of psychiatric disorders. Role: Principal investigator
- NIMH R25 MH019918 2/2024-1/2029 Workshop on statistical genetic methods for human complex traits. Role: Principal investigator
- NIDA R01 DA054087 5/1/2022 – 4/30/2027 Understanding the links between parental and adolescent substance use: complementary natural experiments using the children of twins design. Role: Co-Principal investigator
- NIDA R01 DA046064 4/2018-1/2023 Brain and genetic predictors of individual differences in pain and placebo analgesia. Role: Co-investigator
- NIDA R01 DA044283 5/2019 – 2/2024 Deep sequencing, phenotyping, and imputation in large-scale biobanks: A novel and cost-effective framework to identify rare mutations associated with addiction. Role: Principal investigator of subcontract
- NIDA R01 DA053693 4/2024 – 3/2028 Adult Progression of Adolescent Onset Substance Use Disorder in a High Risk Sample. Role: Co-investigator
Additional Resources:
Current Lab
![Kristen Kelly](https://www.colorado.edu/ibg/profiles/express/modules/features/people_content_type/images/avatar320.jpg)
![Xuanyu Lyu portrait](https://www.colorado.edu/ibg/sites/default/files/styles/large_square_thumbnail/public/people/xuanyu_lyu.jpeg?itok=u78B5eAq)
![Pamela Romero-Villela portrait](https://www.colorado.edu/ibg/sites/default/files/styles/large_square_thumbnail/public/people/romero-villela_pamela-2-small.jpg?itok=mLXZxlpl)
![Emmanuel Sapin](https://www.colorado.edu/ibg/profiles/express/modules/features/people_content_type/images/avatar320.jpg)
![Noemie Valenza-Troubat portrait](https://www.colorado.edu/ibg/sites/default/files/styles/large_square_thumbnail/public/people/noemie_valenza.png?itok=K_WRlcx_)
![Katerina Zorina portrait](https://www.colorado.edu/ibg/sites/default/files/styles/large_square_thumbnail/public/people/zorina_katerina-2-small.jpg?itok=wiLBk3HR)
Former Trainees
Spencer Moore
Masters student
2020-2022
Jared Balbona
Doctoral student
2018-2022
Richard Border
Doctoral student
2014-2019
Emma Johnson
Doctoral student
2012-2017
Teresa de Candia
Doctoral student
2011-2015
Matthew Simonson
Doctoral student
2008-2013
Dan Howrigan
Doctoral student
2008-2012
Laramie Duncan
Doctoral student
2008-2010
Subrata Paul
Postdoctoral trainee
2020-2021
Meng Huang
Postdoctoral trainee
2020-2021
Rasool Tahmasbi
Postdoctoral trainee
2015-2018
Luke Evans
Postdoctoral trainee
2015-2018
Doug Bjelland
Postdoctoral trainee
2013-2016
Christine Garver-Apgar
Postdoctoral trainee
2008-2011
Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank
Publication Date: 2024-05-06
Type: Journal Article
Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling
Zorina-Lichtenwalter K; Bango CI; Van Oudenhove L; Ceko M; Lindquist MA; Grotzinger AD; Keller MC; Friedman NP; Wager TD...
- Zorina-Lichtenwalter K
- Bango CI
- Van Oudenhove L
- Ceko M
- Lindquist MA
- Grotzinger AD
- Keller MC
- Friedman NP
- Wager TD
Publication Date: 2023-10-01
Type: Journal Article
The challenges of sociogenomics make it more, not less, worthy of careful and innovative investigation
Publication Date: 2023-09-11
Type: Journal Article
Evidence of correlations between human partners based on systematic reviews and meta-analyses of 22 traits and UK Biobank analysis of 133 traits
Publication Date: 2023-09-01
Type: Journal Article
Evidence of correlations between human partners based on systematic reviews and meta-analyses of 22 traits and UK Biobank analysis of 133 traits
Publication Date: 2023-09-01
Type: Journal Article
Genetic relationships between chronic pain, psychopathologies, and neuroticism
Type: Journal Article
Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts
Publication Date: 2023-06-01
Type: Journal Article
Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
Axelrud LK; Hoffmann MS; Vosberg DE; Santoro M; Pan PM; Gadelha A; Belangero SI; Miguel EC; Shin J; Thapar A...
- Axelrud LK
- Hoffmann MS
- Vosberg DE
- Santoro M
- Pan PM
- Gadelha A
- Belangero SI
- Miguel EC
- Shin J
- Thapar A
Publication Date: 2023-03-01
Type: Journal Article
Genome-wide Association Study Shows That Executive Functioning Is Influenced by GABAergic Processes and Is a Neurocognitive Genetic Correlate of Psychiatric Disorders
Hatoum AS; Morrison CL; Mitchell EC; Lam M; Benca-Bachman CE; Reineberg AE; Palmer RHC; Evans LM; Keller MC; Friedman NP...
- Hatoum AS
- Morrison CL
- Mitchell EC
- Lam M
- Benca-Bachman CE
- Reineberg AE
- Palmer RHC
- Evans LM
- Keller MC
- Friedman NP
Publication Date: 2023-01-01
Type: Journal Article
The estimation of environmental and genetic parental influences
Publication Date: 2022-12-01
Type: Journal Article
Potential bias in genetic correlations Mating patterns across two traits can inflate estimates of genetic overlap
Publication Date: 2022-11-18
Type: Journal Article
Exploring the Relationships Between autozygosity, Educational Attainment, and Cognitive Ability in a Contemporary, Trans-ancestral American Sample
Publication Date: 2022-11-01
Type: Journal Article
Rare genetic variants explain missing heritability in smoking
Jang S-K; Evans L; Fialkowski A; Arnett DK; Ashley-Koch AE; Barnes KC; Becker DM; Bis JC; Blangero J; Bleecker ER...
- Jang S-K
- Evans L
- Fialkowski A
- Arnett DK
- Ashley-Koch AE
- Barnes KC
- Becker DM
- Bis JC
- Blangero J
- Bleecker ER
Publication Date: 2022-11-01
Type: Journal Article
Loci on Chromosome 20 Interact with rs16969968 to Influence Cigarettes per Day in European Ancestry Individuals
Type: Journal Article
Predicting causal genes from psychiatric genome-wide association studies using high-level etiological knowledge
Publication Date: 2022-07-01
Type: Journal Article
Identification and characterization of genetic risk shared across 24 chronic pain conditions in the UK Biobank
Zorina-Lichtenwalter K; Bango CI; Van Oudenhove L; Čeko M; Lindquist MA; Grotzinger AD; Keller MC; Friedman NP; Wager T...
- Zorina-Lichtenwalter K
- Bango CI
- Van Oudenhove L
- Čeko M
- Lindquist MA
- Grotzinger AD
- Keller MC
- Friedman NP
- Wager TD
Type: Journal Article
A Comprehensive Meta-analysis of Human Assortative Mating in 22 Complex Traits
Publication Date: 2022-06-22
Type: Conference Proceeding
Evaluating the Regional and Functional Overlap of Rare and Common Variant Signals Across Complex Traits
Publication Date: 2022-06-22
Type: Conference Proceeding
Genomic Structural Equation Modeling Links Chronic Pain, Psychopathology, and Neuroticism
Publication Date: 2022-06-22
Type: Conference Proceeding
Gametic Phasing Leading to Detection and Correction of Mendelian Errors
Publication Date: 2022-06-22
Type: Conference Proceeding
Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities
Mallard TT; Linner RK; Grotzinger AD; Sanchez-Roige S; Seidlitz J; Okbay A; de Vlaming R; Meddens SFW; Palmer AA; Davis ...
- Mallard TT
- Linner RK
- Grotzinger AD
- Sanchez-Roige S
- Seidlitz J
- Okbay A
- de Vlaming R
- Meddens SFW
- Palmer AA
- Davis LK
Publication Date: 2022-06-08
Type: Journal Article
An evolutionary investigation of depressed mood: The relationship between daily stressors and patterns of depressive symptoms
Publication Date: 2022-06-04
Type: Journal Article
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Howe LJ; Nivard MG; Morris TT; Hansen AF; Rasheed H; Cho Y; Chittoor G; Ahlskog R; Lind PA; Palviainen T...
- Howe LJ
- Nivard MG
- Morris TT
- Hansen AF
- Rasheed H
- Cho Y
- Chittoor G
- Ahlskog R
- Lind PA
- Palviainen T
Publication Date: 2022-05-01
Type: Journal Article
Assortative mating biases marker-based heritability estimators (vol 13, pg 660, 2022)
Publication Date: 2022-04-01
Type: Journal Article
Correlations between human mating partners: a comprehensive meta-analysis of 22 traits and raw data analysis of 133 traits in the UK Biobank
Type: Journal Article
Pages
Recruiting
The Keller lab is not currently recruiting new graduate students.
Contact Matt Keller directly about postdoctoral trainee positions.