
Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447
Research Interests:
Developing models to understand complex trait genetics. Using family-based GWAS datasets to estimate direct genetic effects and the environmental influences of parents on offspring. Modeling and simulating genetically informative designs that better enable us to understand the causes of human differences.
Active Grants:
- NIMH R01 MH130448 7/2022-6/2027 Causes and consequences of mental disorders: The environmental and genetic influences of parents on offspring. Role: Principal investigator
- NIMH 2R01 MH100141 2/2013-4/2023 Estimating the genetic and environmental architecture of psychiatric disorders. Role: Principal investigator NIMH R25 MH019918 2/2019-1/2024 Workshop on statistical genetic methods for human complex traits. Role: Principal investigator
- NIMH R25 MH019918 2/2024-4/2029 This grant educates researchers in whole-genome and twin statistical genetic techniques in yearly week-long workshops. Role: Principal investigator
- NIDA R01 DA054087 5/1/2022 – 4/30/2027 Understanding the links between parental and adolescent substance use: complementary natural experiments using the children of twins design. Role: Co-Principal investigator
- NIDA R01 DA046064 4/2018-1/2023 Brain and genetic predictors of individual differences in pain and placebo analgesia. Role: Co-investigator
- NIDA R01 DA044283 5/2019 – 2/2024 Deep sequencing, phenotyping, and imputation in large-scale biobanks: A novel and cost-effective framework to identify rare mutations associated with addiction. Role: Principal investigator of subcontract
- NIDA R01 DA053693 4/2021 – 3/2026 Deep sequencing, phenotyping, and imputation in large-scale biobanks: A novel and cost-effective framework to identify rare mutations associated with addiction. Role: Co-investigator
Additional Resources:
Current Lab






Former Trainees
Spencer Moore
Masters student
2020-2022
Jared Balbona
Doctoral student
2018-2022
Richard Border
Doctoral student
2014-2019
Emma Johnson
Doctoral student
2012-2017
Teresa de Candia
Doctoral student
2011-2015
Matthew Simonson
Doctoral student
2008-2013
Dan Howrigan
Doctoral student
2008-2012
Laramie Duncan
Doctoral student
2008-2010
Subrata Paul
Postdoctoral trainee
2020-2021
Meng Huang
Postdoctoral trainee
2020-2021
Rasool Tahmasbi
Postdoctoral trainee
2015-2018
Luke Evans
Postdoctoral trainee
2015-2018
Doug Bjelland
Postdoctoral trainee
2013-2016
Christine Garver-Apgar
Postdoctoral trainee
2008-2011
Shared additive genetic variation for alcohol dependence among subjects of African and European ancestry
Publication Date: 2019-01-01
Type: Journal Article
Type I Error Rates and Parameter Bias in Multivariate Behavioral Genetic Models.
Type: Journal Article
Imprint of assortative mating on the human genome
Yengo L; Robinson MR; Keller MC; Kemper KE; Yang Y; Trzaskowski M; Gratten J; Turley P; Cesarini D; Benjamin DJ...
- Yengo L
- Robinson MR
- Keller MC
- Kemper KE
- Yang Y
- Trzaskowski M
- Gratten J
- Turley P
- Cesarini D
- Benjamin DJ
Publication Date: 2018-12-01
Type: Journal Article
Narrow-sense heritability estimation of complex traits using identity-by-descent information
Evans LM; Tahmasbi R; Jones M; Vrieze S; Abecasis GR; Das S; Bjelland DW; de Candia TR; Yang J; Goddard ME...
- Evans LM
- Tahmasbi R
- Jones M
- Vrieze S
- Abecasis GR
- Das S
- Bjelland DW
- de Candia TR
- Yang J
- Goddard ME
Publication Date: 2018-12-01
Type: Journal Article
Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018)
Lam M; Trampush JW; Yu J; Knowles E; Djurovic S; Melle I; Sundet K; Christoforou A; Reinvang I; DeRosse P...
- Lam M
- Trampush JW
- Yu J
- Knowles E
- Djurovic S
- Melle I
- Sundet K
- Christoforou A
- Reinvang I
- DeRosse P
Publication Date: 2018-10-01
Type: Journal Article
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Savage JE; Jansen PR; Stringer S; Watanabe K; Bryois J; de Leeuw CA; Nagel M; Awasthi S; Barr PB; Coleman JRI...
- Savage JE
- Jansen PR
- Stringer S
- Watanabe K
- Bryois J
- de Leeuw CA
- Nagel M
- Awasthi S
- Barr PB
- Coleman JRI
Publication Date: 2018-07-01
Type: Journal Article
Relationships between estimated autozygosity and complex traits in the UK Biobank
Publication Date: 2018-07-01
Type: Journal Article
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Davies G; Lam M; Harris SE; Trampush JW; Luciano M; Hill WD; Hagenaars SP; Ritchie SJ; Marioni RE; Fawns-Ritchie C...
- Davies G
- Lam M
- Harris SE
- Trampush JW
- Luciano M
- Hill WD
- Hagenaars SP
- Ritchie SJ
- Marioni RE
- Fawns-Ritchie C
Publication Date: 2018-05-29
Type: Journal Article
Evolutionary Perspectives on Genetic and Environmental Risk Factors for Psychiatric Disorders.
Publication Date: 2018-05-07
Type: Journal Article
Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits
Evans LM; Tahmasbi R; Vrieze SI; Abecasis GR; Das S; Gazal S; Bjelland DW; de Candia TR; Goddard ME; Neale BM...
- Evans LM
- Tahmasbi R
- Vrieze SI
- Abecasis GR
- Das S
- Gazal S
- Bjelland DW
- de Candia TR
- Goddard ME
- Neale BM
Publication Date: 2018-05-01
Type: Journal Article
GWAS meta-analysis (N=279,930) identifies new genes and functional links to general cognitive ability
Savage JE; Jansen PR; Stringer S; Watanabe K; Bryois J; de Leeuw CA; Nagel M; Awasthi S; Barr PB; Coleman JRI...
- Savage JE
- Jansen PR
- Stringer S
- Watanabe K
- Bryois J
- de Leeuw CA
- Nagel M
- Awasthi S
- Barr PB
- Coleman JRI
Publication Date: 2018-03-09
Type: Conference Proceeding
Using partitioned heritability methods to explore genetic architecture
Publication Date: 2018-03-01
Type: Journal Article
Evolutionary Perspectives on Genetic and Environmental Risk Factors for Psychiatric Disorders
Publication Date: 2018-01-01
Type: Chapter
Facial Trustworthiness is Associated with Heritable Aspects of Face Shape
Publication Date: 2017-12-01
Type: Journal Article
Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets
Publication Date: 2017-11-28
Type: Journal Article
No Evidence That Schizophrenia Candidate Genes Are More Associated With Schizophrenia Than Noncandidate Genes
Publication Date: 2017-11-15
Type: Journal Article
Assessing the accuracy of perceptions of intelligence based on heritable facial features
Publication Date: 2017-09-01
Type: Journal Article
Genetic influences on the human oral microbiome
Demmitt BA; Corley RP; Huibregtse BM; Keller MC; Hewitt JK; McQueen MB; Knight R; McDermott I; Krauter KS...
- Demmitt BA
- Corley RP
- Huibregtse BM
- Keller MC
- Hewitt JK
- McQueen MB
- Knight R
- McDermott I
- Krauter KS
Publication Date: 2017-08-24
Type: Journal Article
A fast and accurate method for detection of IBD shared haplotypes in genome-wide SNP data
Publication Date: 2017-05-01
Type: Journal Article
Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci
Publication Date: 2017-04-01
Type: Journal Article
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
Trampush JW; Yang MLZ; Yu J; Knowles E; Davies G; Liewald DC; Starr JM; Djurovic S; Melle I; Sundet K...
- Trampush JW
- Yang MLZ
- Yu J
- Knowles E
- Davies G
- Liewald DC
- Starr JM
- Djurovic S
- Melle I
- Sundet K
Publication Date: 2017-03-01
Type: Journal Article
Commentary: Fundamental problems with candidate gene-by-environment interaction studies - reflections on Moore and Thoemmes (2016)
Publication Date: 2017-03-01
Type: Journal Article
GeneEvolve: a fast and memory efficient forward-time simulator of realistic whole-genome sequence and SNP data
Publication Date: 2017-01-15
Type: Journal Article
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Marshall CR; Howrigan DP; Merico D; Thiruvahindrapuram B; Wu W; Greer DS; Antaki D; Shetty A; Holmans PA; Pinto D...
- Marshall CR
- Howrigan DP
- Merico D
- Thiruvahindrapuram B
- Wu W
- Greer DS
- Antaki D
- Shetty A
- Holmans PA
- Pinto D
Publication Date: 2017-01-01
Type: Journal Article
Predicting Cognitive Executive Functioning with Polygenic Risk Scores for Psychiatric Disorders
Publication Date: 2017-01-01
Type: Journal Article
Pages
Recruiting
The Keller lab is recruiting new graduate students.
Contact Matt Keller directly about postdoctoral trainee positions.