Luke Evans portrait
Assistant Professor • Publications
Institute for Behavioral Genetics • Ecology & Evolutionary Biology
luke.m.evans@colorado.edu

Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447

Research Interests:

Methods for estimating heritability and investigating genomic architecture of complex traits. Recent work focuses on the heritability and genetic architecture of psychiatric disorders.

Active Grants:

  • NIH/NIA 1 R01 AG046938-06 (PI: Reynolds) Colorado Adoption/Twin Study of Lifespan Behavioral Development & Cognitive Aging (CATSLife2). Role: Co-Investigator
  • NIH/NIDA 1 R01 DA044283-01 (PI: Vrieze) Deep sequencing, phenotyping, and imputation in large-scale biobanks: A novel and cost-effective framework to identify rare mutations associated with addiction. Role: Co-Investigator
  • NIH/NIMH 5 R01 MH100141-06 (PI: Keller) Estimating the genetic and environmental architecture of psychiatric disorders. Role: Co-Investigator

Additional Resources:

Evans Lab Page

EBIO faculty page

Current CV

 

Current Lab

Christopher Arehart portrait
Christopher Arehart
Predoctoral Trainee
Ecology & Evolutionary Biology
Grace Bowman
Grace Bowman
Predoctoral Trainee
Maizy Brasher portrait
Maizy Brasher
Bachelor's-Accelerated Master's student
Ecology & Evolutionary Biology
Travis Mize portrait
Travis Mize
Predoctoral Trainee
Institute for Behavioral Genetics

Former Trainees

Scott Funkhouser

Postdoctoral trainee, 2019-2021

Publications

Google Scholar - all publications

Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits

CU Boulder Authors: Evans, Luke M.; Hoeffer, Charles Albert; Ehringer, Marissa A
All Authors: Evans LM; Arehart CH; Grotzinger AD; Mize TJ; Brasher MS; Stitzel JA; Ehringer MA; Hoeffer CA
Published in: PLoS Genetics
Publication Date: 2023-05-01
Type: Journal Article

Hippocampal RNA sequencing in mice selectively bred for high and low activity

CU Boulder Authors: Evans, Luke M.; Ehringer, Marissa A
All Authors: Booher WCC; Vanderlinden LAA; Hall LAA; Thomas ALL; Evans LMM; Saba LMM; Ehringer MAA
Published in: Genes, Brain and Behavior
Publication Date: 2023-04-01
Type: Journal Article

Contribution of rare variants to traits

CU Boulder Authors: Evans, Luke M.
All Authors: Evans LMM; Villela PNRN
Published in: Nature
Publication Date: 2023-02-08
Type: Journal Article

Testing Association of Previously Implicated Gene Sets and Gene-Networks in Nicotine Exposed Mouse Models with Human Smoking Phenotypes

CU Boulder Authors: Evans, Luke M.; Stitzel, Jerry A; Ehringer, Marissa A
All Authors: Mize TJ; Funkhouser SA; Buck JM; Stitzel JA; Ehringer MA; Evans LM
Published in: Nicotine and Tobacco Research
Publication Date: 2022-11-29
Type: Conference Proceeding

Examination of a novel expression-based gene-SNP annotation strategy to identify tissue-specific contributions to heritability in multiple traits

CU Boulder Authors: Evans, Luke M.
All Authors: Mize TJ; Evans LM
Published in: European Journal of Human Genetics
Publication Date: 2022-11-29
Type: Journal Article

Genome-wide Association Study Shows That Executive Functioning Is Influenced by GABAergic Processes and Is a Neurocognitive Genetic Correlate of Psychiatric Disorders

CU Boulder Authors: Evans, Luke M.; Keller, Matthew C; Friedman, Naomi P
All Authors:
Hatoum AS; Morrison CL; Mitchell EC; Lam M; Benca-Bachman CE; Reineberg AE; Palmer RHC; Evans LM; Keller MC; Friedman NP...
  • Hatoum AS
  • Morrison CL
  • Mitchell EC
  • Lam M
  • Benca-Bachman CE
  • Reineberg AE
  • Palmer RHC
  • Evans LM
  • Keller MC
  • Friedman NP
Published in: Biological Psychiatry
Publication Date: 2022-11-28
Type: Journal Article

Rare genetic variants explain missing heritability in smoking

CU Boulder Authors: Evans, Luke M.; Keller, Matthew C
All Authors:
Jang S-K; Evans L; Fialkowski A; Arnett DK; Ashley-Koch AE; Barnes KC; Becker DM; Bis JC; Blangero J; Bleecker ER...
  • Jang S-K
  • Evans L
  • Fialkowski A
  • Arnett DK
  • Ashley-Koch AE
  • Barnes KC
  • Becker DM
  • Bis JC
  • Blangero J
  • Bleecker ER
Published in: Nature Human Behaviour
Publication Date: 2022-11-01
Type: Journal Article

Poly-omic risk scores predict inflammatory bowel disease diagnosis

CU Boulder Authors: Evans, Luke M.
All Authors: Arehart CH; Sterrett JD; Garris RL; Quispe-Pilco RE; Gignoux CR; Evans LM; Stanislawski MA
Publication Date: 2022-09-17
Type: Journal Article

Loci on Chromosome 20 Interact with rs16969968 to Influence Cigarettes per Day in European Ancestry Individuals

CU Boulder Authors: Keller, Matthew C; Evans, Luke M.
All Authors: Ehringer M; Villela PR; Palviainen T; Evans L; Border R; Kaprio J; Palmer R; Keller M
Publication Date: 2022-08-30
Type: Journal Article

Transcriptome-Wide Gene-Gene Interaction Association Study Elucidates Pathways and Functional Enrichment of Complex Traits

CU Boulder Authors: Hoeffer, Charles Albert; Evans, Luke M.
All Authors: Evans LM; Arehart CH; Grotzinger AD; Mize TJ; Brasher MS; Stitzel JA; Ehringer MA; Hoeffer CA
Publication Date: 2022-08-17
Type: Journal Article

Testing Human Anxiety Associations of Genes Previously Implicated by Mouse Anxiety Models

CU Boulder Authors: Hoeffer, Charles Albert; Evans, Luke M.; Ehringer, Marissa A
All Authors: Brasher MS; Mize TJ; Thomas AL; Hoeffer CA; Ehringer MA; Evans LM
Publication Date: 2022-07-09
Type: Journal Article

Examination of a Novel Expression-Based Gene-SNP Annotation Strategy to Identify Tissue-Specific Contributions to Heritability in Multiple Traits

CU Boulder Authors: Evans, Luke M.
All Authors: Mize T; Evans L
Publication Date: 2022-07-06
Type: Journal Article

Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms

CU Boulder Authors: Krauter, Kenneth S; Stallings, Michael C; Hewitt, John K; Evans, Luke M.
All Authors:
Jami ES; Hammerschlag AR; Ip HF; Allegrini AG; Benyamin B; Border R; Diemer EW; Jiang C; Karhunen V; Lu Y...
  • Jami ES
  • Hammerschlag AR
  • Ip HF
  • Allegrini AG
  • Benyamin B
  • Border R
  • Diemer EW
  • Jiang C
  • Karhunen V
  • Lu Y
Published in: Journal of the American Academy of Child and Adolescent Psychiatry
Publication Date: 2022-06-27
Type: Journal Article

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

CU Boulder Authors: Keller, Matthew C; Evans, Luke M.; Hewitt, John K; Stallings, Michael C
All Authors:
Howe LJ; Nivard MG; Morris TT; Hansen AF; Rasheed H; Cho Y; Chittoor G; Ahlskog R; Lind PA; Palviainen T...
  • Howe LJ
  • Nivard MG
  • Morris TT
  • Hansen AF
  • Rasheed H
  • Cho Y
  • Chittoor G
  • Ahlskog R
  • Lind PA
  • Palviainen T
Published in: Nature Genetics
Publication Date: 2022-05-01
Type: Journal Article

Does Maternal Smoking During Pregnancy Moderate the Effect of Genes on Offspring's Smoking Behavior?

CU Boulder Authors: Ehringer, Marissa A; Evans, Luke M.; Keller, Matthew C
All Authors: Villela PNR; Balbona JC; Border R; Keller MC; Evans LM; Ehringer MA
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2021-11-01
Type: Conference Proceeding

Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use

CU Boulder Authors: Ehringer, Marissa A; Evans, Luke M.; Hoeffer, Charles Albert; Friedman, Naomi P
All Authors: Colbert SMC; Funkhouser SA; Johnson EC; Morrison CL; Hoeffer CA; Friedman NP; Ehringer MA; Evans LM
Published in: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Publication Date: 2021-09-27
Type: Journal Article

Genetic architecture of four smoking behaviors using partitioned SNP heritability

CU Boulder Authors: Keller, Matthew C; Evans, Luke M.; Ehringer, Marissa A
All Authors: Evans LM; Jang S; Hancock DB; Ehringer MA; Otto JM; Vrieze SI; Keller MC
Published in: Addiction
Publication Date: 2021-09-01
Type: Journal Article

Sexual dimorphism in the dioecious willow Salix purpurea

CU Boulder Authors: Evans, Luke M.
All Authors: Gouker FE; Carlson CH; Zou J; Evans L; Crowell CR; Smart CD; DiFazio SP; Smart LB
Published in: American Journal of Botany
Publication Date: 2021-08-01
Type: Journal Article

Genetic association study of childhood aggression across raters, instruments, and age

CU Boulder Authors: Krauter, Kenneth S; Stallings, Michael C; Evans, Luke M.
All Authors:
Ip HF; van der Laan CM; Krapohl EML; Brikell I; Sanchez-Mora C; Nolte IM; St Pourcain B; Bolhuis K; Palviainen T; Zafarm...
  • Ip HF
  • van der Laan CM
  • Krapohl EML
  • Brikell I
  • Sanchez-Mora C
  • Nolte IM
  • St Pourcain B
  • Bolhuis K
  • Palviainen T
  • Zafarmand H
Published in: Translational Psychiatry
Publication Date: 2021-07-30
Type: Journal Article

Little Evidence of Modified Genetic Effect of rs16969968 on Heavy Smoking Based on Age of Onset of Smoking

CU Boulder Authors: Evans, Luke M.; Ehringer, Marissa A
All Authors: Adjangba C; Border R; Villela PNR; Ehringer MA; Evans LM
Published in: Nicotine and Tobacco Research
Publication Date: 2021-06-01
Type: Journal Article

Genetic data improves niche model discrimination and alters the direction and magnitude of climate change forecasts

CU Boulder Authors: Evans, Luke M.
All Authors: Bothwell HM; Evans LM; Hersch-Green EI; Woolbright SA; Allan GJ; Whitham TG
Published in: Ecological Applications
Publication Date: 2021-01-20
Type: Journal Article

Differential shared genetic influences of anxiety with problematic alcohol use compared to alcohol consumption

CU Boulder Authors: Evans, Luke M.; Ehringer, Marissa A
All Authors: Colbert SMC; Funkhouser S; Johnson EC; Ehringer M; Evans L
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2020-11-01
Type: Journal Article

Whole-Genome Sequencing of Inbred Mouse Strains Selected for High and Low Open-Field Activity

CU Boulder Authors: Ehringer, Marissa A; Evans, Luke M.; Lowry, Christopher A.
All Authors: Thomas AL; Evans LM; Nelsen MD; Chesler EJ; Powers MS; Booher WC; Lowry CA; DeFries JC; Ehringer MA
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2020-09-16
Type: Journal Article

The Role of A Priori-Identified Addiction and Smoking Gene Sets in Smoking Behaviors

CU Boulder Authors: Ehringer, Marissa A; Keller, Matthew C; Stitzel, Jerry A; Hoeffer, Charles Albert; Evans, Luke M.; Hewitt, John K
All Authors:
Evans LM; Johnson EC; Melroy-Greif WE; Hewitt JK; Hoeffer CA; Keller MC; Saba LM; Stitzel JA; Ehringer MA...
  • Evans LM
  • Johnson EC
  • Melroy-Greif WE
  • Hewitt JK
  • Hoeffer CA
  • Keller MC
  • Saba LM
  • Stitzel JA
  • Ehringer MA
Published in: Nicotine and Tobacco Research
Publication Date: 2020-08-01
Type: Journal Article

No significant interaction between rs16969968 and genome-wide loci to predict cigarettes per day in the UK Biobank

CU Boulder Authors: Keller, Matthew C; Ehringer, Marissa A; Evans, Luke M.
All Authors: Villela PNR; Border R; Keller MC; Evans LM; Ehringer MA
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2020-06-26
Type: Conference Proceeding

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