Luke Evans portrait
Assistant Professor • Publications
Institute for Behavioral Genetics • Ecology & Evolutionary Biology
luke.m.evans@colorado.edu

Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447

Research Interests:

Methods for estimating heritability and investigating genomic architecture of complex traits. Recent work focuses on the heritability and genetic architecture of psychiatric disorders.

Active Grants:

  • NIH/NIA 1 R01 AG046938-06 (PI: Reynolds) Colorado Adoption/Twin Study of Lifespan Behavioral Development & Cognitive Aging (CATSLife2). Role: Co-Investigator
  • NIH/NIDA 1 R01 DA044283-01 (PI: Vrieze) Deep sequencing, phenotyping, and imputation in large-scale biobanks: A novel and cost-effective framework to identify rare mutations associated with addiction. Role: Co-Investigator
  • NIH/NIMH 5 R01 MH100141-06 (PI: Keller) Estimating the genetic and environmental architecture of psychiatric disorders. Role: Co-Investigator

Additional Resources:

Evans Lab Page

EBIO faculty page

Current CV

 

Current Lab

Christopher Arehart portrait
Christopher Arehart
Predoctoral Trainee
Ecology & Evolutionary Biology
Maizy Brasher portrait
Maizy Brasher
Bachelor's-Accelerated Master's student
Ecology & Evolutionary Biology
Travis Mize portrait
Travis Mize
Predoctoral Trainee
Institute for Behavioral Genetics

Former Trainees

Scott Funkhouser

Postdoctoral trainee, 2019-2021

Publications

Google Scholar - all publications

How rare mutations contribute to complex traits

CU Boulder Authors: Evans, Luke M.
All Authors: Evans LM; Romero Villela PN
Published in: Nature
Publication Date: 2023-02-16
Type: Journal Article

Genome-wide Association Study Shows That Executive Functioning Is Influenced by GABAergic Processes and Is a Neurocognitive Genetic Correlate of Psychiatric Disorders

CU Boulder Authors: Evans, Luke M.; Keller, Matthew C; Friedman, Naomi P
All Authors:
Hatoum AS; Morrison CL; Mitchell EC; Lam M; Benca-Bachman CE; Reineberg AE; Palmer RHC; Evans LM; Keller MC; Friedman NP...
  • Hatoum AS
  • Morrison CL
  • Mitchell EC
  • Lam M
  • Benca-Bachman CE
  • Reineberg AE
  • Palmer RHC
  • Evans LM
  • Keller MC
  • Friedman NP
Published in: Biological Psychiatry
Publication Date: 2023-01-01
Type: Journal Article

Hippocampal RNA sequencing in mice selectively bred for high and low activity

CU Boulder Authors: Evans, Luke M.; Ehringer, Marissa A
All Authors: Booher WCC; Vanderlinden LAA; Hall LAA; Thomas ALL; Evans LMM; Saba LMM; Ehringer MAA
Published in: Genes, Brain and Behavior
Publication Date: 2022-12-13
Type: Journal Article

Examination of a novel expression-based gene-SNP annotation strategy to identify tissue-specific contributions to heritability in multiple traits

CU Boulder Authors: Evans, Luke M.
All Authors: Mize TJ; Evans LM
Published in: European Journal of Human Genetics
Publication Date: 2022-11-29
Type: Journal Article

Rare genetic variants explain missing heritability in smoking

CU Boulder Authors: Evans, Luke M.; Keller, Matthew C
All Authors:
Jang S-K; Evans L; Fialkowski A; Arnett DK; Ashley-Koch AE; Barnes KC; Becker DM; Bis JC; Blangero J; Bleecker ER...
  • Jang S-K
  • Evans L
  • Fialkowski A
  • Arnett DK
  • Ashley-Koch AE
  • Barnes KC
  • Becker DM
  • Bis JC
  • Blangero J
  • Bleecker ER
Published in: Nature Human Behaviour
Publication Date: 2022-08-04
Type: Journal Article

Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms

CU Boulder Authors: Hewitt, John K; Stallings, Michael C; Evans, Luke M.; Krauter, Kenneth S
All Authors:
Jami ES; Hammerschlag AR; Ip HF; Allegrini AG; Benyamin B; Border R; Diemer EW; Jiang C; Karhunen V; Lu Y...
  • Jami ES
  • Hammerschlag AR
  • Ip HF
  • Allegrini AG
  • Benyamin B
  • Border R
  • Diemer EW
  • Jiang C
  • Karhunen V
  • Lu Y
Published in: Journal of the American Academy of Child and Adolescent Psychiatry
Publication Date: 2022-06-27
Type: Journal Article

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

CU Boulder Authors: Evans, Luke M.; Keller, Matthew C; Hewitt, John K
All Authors:
Howe LJ; Nivard MG; Morris TT; Hansen AF; Rasheed H; Cho Y; Chittoor G; Ahlskog R; Lind PA; Palviainen T...
  • Howe LJ
  • Nivard MG
  • Morris TT
  • Hansen AF
  • Rasheed H
  • Cho Y
  • Chittoor G
  • Ahlskog R
  • Lind PA
  • Palviainen T
Published in: Nature Genetics
Publication Date: 2022-05-09
Type: Journal Article

Testing Association of Previously Implicated Gene-Sets in Nicotine Exposed Mouse Models with Human Smoking Phenotypes

CU Boulder Authors: Evans, Luke M.; Stitzel, Jerry A; Ehringer, Marissa A
All Authors: Mize TJ; Funkhouser SA; Buck JM; Stitzel JA; Ehringer MA; Evans LM
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2021-11-01
Type: Conference Proceeding

Does Maternal Smoking During Pregnancy Moderate the Effect of Genes on Offspring's Smoking Behavior?

CU Boulder Authors: Keller, Matthew C; Evans, Luke M.; Ehringer, Marissa A
All Authors: Villela PNR; Balbona JC; Border R; Keller MC; Evans LM; Ehringer MA
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2021-11-01
Type: Conference Proceeding

Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use

CU Boulder Authors: Ehringer, Marissa A; Hoeffer, Charles Albert; Evans, Luke M.; Friedman, Naomi P
All Authors: Colbert SMC; Funkhouser SA; Johnson EC; Morrison CL; Hoeffer CA; Friedman NP; Ehringer MA; Evans LM
Published in: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Publication Date: 2021-09-27
Type: Journal Article

Sexual dimorphism in the dioecious willow; Salix purpurea

CU Boulder Authors: Evans, Luke M.
All Authors: Gouker FE; Carlson CH; Zou J; Evans L; Crowell CR; Smart CD; DiFazio SP; Smart LB
Published in: American Journal of Botany
Publication Date: 2021-08-01
Type: Journal Article

Genetic association study of childhood aggression across raters, instruments, and age

CU Boulder Authors: Krauter, Kenneth S; Evans, Luke M.; Stallings, Michael C
All Authors:
Ip HF; van der Laan CM; Krapohl EML; Brikell I; Sanchez-Mora C; Nolte IM; St Pourcain B; Bolhuis K; Palviainen T; Zafarm...
  • Ip HF
  • van der Laan CM
  • Krapohl EML
  • Brikell I
  • Sanchez-Mora C
  • Nolte IM
  • St Pourcain B
  • Bolhuis K
  • Palviainen T
  • Zafarmand H
Published in: Translational Psychiatry
Publication Date: 2021-07-30
Type: Journal Article

Little Evidence of Modified Genetic Effect of rs16969968 on Heavy Smoking Based on Age of Onset of Smoking

CU Boulder Authors: Evans, Luke M.; Ehringer, Marissa A
All Authors: Adjangba C; Border R; Villela PNR; Ehringer MA; Evans LM
Published in: Nicotine and Tobacco Research
Publication Date: 2021-06-01
Type: Journal Article

Genetic architecture of four smoking behaviors using partitioned SNP heritability

CU Boulder Authors: Ehringer, Marissa A; Keller, Matthew C; Evans, Luke M.
All Authors: Evans LM; Jang S; Hancock DB; Ehringer MA; Otto JM; Vrieze SI; Keller MC
Published in: Addiction
Publication Date: 2021-03-05
Type: Journal Article

Genetic data improves niche model discrimination and alters the direction and magnitude of climate change forecasts

CU Boulder Authors: Evans, Luke M.
All Authors: Bothwell HM; Evans LM; Hersch-Green EI; Woolbright SA; Allan GJ; Whitham TG
Published in: Ecological Applications
Publication Date: 2021-01-20
Type: Journal Article

Differential shared genetic influences of anxiety with problematic alcohol use compared to alcohol consumption

CU Boulder Authors: Evans, Luke M.; Ehringer, Marissa A
All Authors: Colbert SMC; Funkhouser S; Johnson EC; Ehringer M; Evans L
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2020-11-01
Type: Journal Article

Whole-Genome Sequencing of Inbred Mouse Strains Selected for High and Low Open-Field Activity

CU Boulder Authors: Ehringer, Marissa A; Lowry, Christopher A.; Evans, Luke M.
All Authors: Thomas AL; Evans LM; Nelsen MD; Chesler EJ; Powers MS; Booher WC; Lowry CA; DeFries JC; Ehringer MA
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2020-09-16
Type: Journal Article

The Role of A Priori-Identified Addiction and Smoking Gene Sets in Smoking Behaviors

CU Boulder Authors: Ehringer, Marissa A; Evans, Luke M.; Keller, Matthew C; Stitzel, Jerry A; Hoeffer, Charles Albert; Hewitt, John K
All Authors:
Evans LM; Johnson EC; Melroy-Greif WE; Hewitt JK; Hoeffer CA; Keller MC; Saba LM; Stitzel JA; Ehringer MA...
  • Evans LM
  • Johnson EC
  • Melroy-Greif WE
  • Hewitt JK
  • Hoeffer CA
  • Keller MC
  • Saba LM
  • Stitzel JA
  • Ehringer MA
Published in: Nicotine and Tobacco Research
Publication Date: 2020-08-01
Type: Journal Article

No significant interaction between rs16969968 and genome-wide loci to predict cigarettes per day in the UK Biobank

CU Boulder Authors: Ehringer, Marissa A; Keller, Matthew C; Evans, Luke M.
All Authors: Villela PNR; Border R; Keller MC; Evans LM; Ehringer MA
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2020-06-26
Type: Conference Proceeding

Investigating heterogenous genetic effects contributing to smoking behavior using the UK Biobank

CU Boulder Authors: Boardman, Jason D; Hewitt, John K; Evans, Luke M.; Stallings, Michael C; Keller, Matthew C
All Authors: Funkhouser SA; Evans LM
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2020-06-26
Type: Conference Proceeding

Joint linkage and association mapping of complex traits in shrub willow (Salix purpurea L.)

CU Boulder Authors: Evans, Luke M.
All Authors: Carlson CH; Gouker FE; Crowell CR; Evans L; DiFazio SP; Smart CD; Smart LB
Published in: Annals of Botany
Publication Date: 2019-10-29
Type: Journal Article

Measurement Error Cannot Account for Failed Replications of Historic Candidate Gene-by-Environment Hypotheses: Response to Vrshek-Schallhorn et al.

CU Boulder Authors: Keller, Matthew C; Evans, Luke M.
All Authors: Border R; Johnson EC; Evans LM; Keller MC
Published in: American Journal of Psychiatry
Publication Date: 2019-08-01
Type: Journal Article

Multitrait genome‐wide association analysis of; Populus trichocarpa; identifies key polymorphisms controlling morphological and physiological traits

CU Boulder Authors: Evans, Luke M.
All Authors:
Chhetri HB; Macaya‐Sanz D; Kainer D; Biswal AK; Evans LM; Chen J; Collins C; Hunt K; Mohanty SS; Rosenstiel T...
  • Chhetri HB
  • Macaya‐Sanz D
  • Kainer D
  • Biswal AK
  • Evans LM
  • Chen J
  • Collins C
  • Hunt K
  • Mohanty SS
  • Rosenstiel T
Published in: New Phytologist
Publication Date: 2019-07-01
Type: Journal Article

Imputation of behavioral candidate gene repeat variants in 486,551 publicly-available UK Biobank individuals

CU Boulder Authors: Stallings, Michael C; Evans, Luke M.; Keller, Matthew C; McQueen, Matt; Hewitt, John K; Krauter, Kenneth S
All Authors:
Border R; Smolen A; Corley RP; Stallings MC; Brown SA; Conger RD; Derringer J; Donnellan MB; Haberstick BC; Hewitt JK...
  • Border R
  • Smolen A
  • Corley RP
  • Stallings MC
  • Brown SA
  • Conger RD
  • Derringer J
  • Donnellan MB
  • Haberstick BC
  • Hewitt JK
Published in: European Journal of Human Genetics
Publication Date: 2019-06-01
Type: Journal Article

No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples

CU Boulder Authors: Evans, Luke M.; Keller, Matthew C
All Authors: Border R; Johnson EC; Evans LM; Smolen A; Berley N; Sullivan PF; Keller MC
Published in: American Journal of Psychiatry
Publication Date: 2019-05-01
Type: Journal Article

Pages