• IBG Journal Club is held on most Fridays during the fall and spring semesters at 4pm in the IBG building second floor interactive space.
  • Questions about the fall 2023 journal club should be directed to Andrew Grotzinger.
  • To sign up for Journal Club
    • Edit an unclaimed Journal Club entry on the IBG Events calendar
    • Add your name and the title of the paper to the calendar entry
    • Include a link to the paper in the notes section of the calendar entry
    • Add the names of your discussants to the notes section
    • Send the date, discussant names, title, and a copy of the paper to Janna Vannorsdel

Article Bank

Problems with inferring natural selection in genomic data: overview

Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Cultural hitchhiking and competition between patrilineal kin groups explain the post-Neolithic Y-chromosome bottleneck

Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease

Importance and information: Fits our Alzheimer's disease theme and includes SomaScan results.  (We have submitted a CATSLife supplemental grant to have a longitudinal SomaScan performed on a subset of the CATSLife participants.)

Submitted September, 2022

Blots on a Field?

Expose on the fabrication in multiple Alzheimer's disease studies. A nice article both for ethics and for being AD-related. See also the commentary here: https://www.science.org/content/blog-post/faked-beta-amyloid-data-what-does-it-mean

Submitted: September, 2022

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

Largest GWAS on AD

Submitted: September, 2022

The road to restoring neural circuits for the treatment of Alzheimer’s disease

This review focusses on how an understanding of neural circuitry underlying AD can inform treatment

Submitted: September, 2022

Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches

This is a review of animal and cellular models of AD

Submitted: September, 2022

Omics in Neurodegenerative Disease: Hope or Hype?

This review is skeptical of the potential for omics research to be the key to unlocking neurodegenerative disease.

Submitted: September, 2022

Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective

A review of animal model research in AD and Parkinson's

Submitted: September, 2022

Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability

This article describes how heterogeneity in cohorts contributing to meta-analysis can decrease SNP-based heritability while simultaneously increasing PGS R2.

Article bank submission

To add an item to the article bank, complete this form. Adding the article is a manual process, so please allow some time for updates. To remove an article from the bank, contact Jeff Lessem.

Enter the title of the article.
Enter the URL to the paper (DOI, direct link to journal, etc.)
An explanation of why this paper will be interesting to discuss at journal club, or other information relevant to the paper, such as replies or rebuttals.