Journal Club

  • IBG Journal Club is held on most Fridays during the fall and spring semesters at 2pm in the IBG building second floor interactive space.
  • Questions about the fall 2024 journal club should be directed to Andrew Grotzinger.
  • To sign up for Journal Club
    • Edit an unclaimed Journal Club entry on the IBG Events calendar
    • Add your name and the title of the paper to the calendar entry
    • Include a link to the paper in the notes section of the calendar entry
    • Add the names of your discussants to the notes section
    • Send the date, discussant names, title, and a copy of the paper to Janna Vannorsdel

Article Bank

Problems with inferring natural selection in genomic data: overview

Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Cultural hitchhiking and competition between patrilineal kin groups explain the post-Neolithic Y-chromosome bottleneck

Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease

Importance and information: Fits our Alzheimer's disease theme and includes SomaScan results.  (We have submitted a CATSLife supplemental grant to have a longitudinal SomaScan performed on a subset of the CATSLife participants.)

Submitted September, 2022

Blots on a Field?

Expose on the fabrication in multiple Alzheimer's disease studies. A nice article both for ethics and for being AD-related. See also the commentary here: https://www.science.org/content/blog-post/faked-beta-amyloid-data-what-does-it-mean

Submitted: September, 2022

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer’s disease

Largest GWAS on AD

Submitted: September, 2022

The road to restoring neural circuits for the treatment of Alzheimer’s disease

This review focusses on how an understanding of neural circuitry underlying AD can inform treatment

Submitted: September, 2022

Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches

This is a review of animal and cellular models of AD

Submitted: September, 2022

Omics in Neurodegenerative Disease: Hope or Hype?

This review is skeptical of the potential for omics research to be the key to unlocking neurodegenerative disease.

Submitted: September, 2022

Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective

A review of animal model research in AD and Parkinson's

Submitted: September, 2022

Polygenic risk prediction: why and when out-of-sample prediction R2 can exceed SNP-based heritability

This article describes how heterogeneity in cohorts contributing to meta-analysis can decrease SNP-based heritability while simultaneously increasing PGS R2.