Andrew Grotzinger portrait
Assistant Professor
Psychology & Neuroscience • Institute for Behavioral Genetics
Andrew.Grotzinger@colorado.edu

Research Interests:

Multivariate genomic methods development and their application to psychiatric and cognitive traits.

Active Grants:

  • NIA RF1 AG073593 (Tucker-Drob) 8/15/2021 – 7/31/2024 Large-scale Genomic Analysis of Aging-related Cognitive Change Prior to Dementia Onset. Role: Co-Investigator
  • NIMH R01 MH120219 (Nivard & Tucker-Drob) 07/17/2020-04/30/2025 Dissecting the Multivariate Genetic Architecture of Psychiatric Diseases. Role: Co-Investigator

Current lab

Sophie Breunig portrait
Sophie Breunig
Predoctoral Trainee
Institute for Behavioral Genetics
Isabelle Foote portrait
Isabelle Foote
Postdoctoral Associate
Institute for Behavioral Genetics
Jeremy Lawrence portrait
Jeremy Lawrence
Predoctoral Trainee
Institute for Behavioral Genetics

Publications

Google Scholar

Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis: A Simple Solution

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Grotzinger AD; de la Fuente J; Prive F; Nivard MG; Tucker-Drob EM
Published in: Biological Psychiatry
Publication Date: 2023-01-01
Type: Journal Article

Potential bias in genetic correlations Mating patterns across two traits can inflate estimates of genetic overlap

CU Boulder Authors: Grotzinger, Andrew David; Keller, Matthew C
All Authors: Grotzinger AD; Keller MC
Published in: Science
Publication Date: 2022-11-18
Type: Journal Article

A Mixed-Methods Approach to Refining and Measuring the Construct of Positive Risk-Taking in Adolescence

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Patterson MW; Pivnick L; Mann FD; Grotzinger AD; Monahan KC; Steinberg LD; Oosterhoff B; Tackett JL; Tucker-Drob EM; Har...
  • Patterson MW
  • Pivnick L
  • Mann FD
  • Grotzinger AD
  • Monahan KC
  • Steinberg LD
  • Oosterhoff B
  • Tackett JL
  • Tucker-Drob EM
  • Harden KP
Published in: Journal of Research on Adolescence
Publication Date: 2022-11-10
Type: Journal Article

Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Grotzinger AD; de la Fuente J; Davies G; Nivard MG; Tucker-Drob EM
Published in: Nature Communications
Publication Date: 2022-10-21
Type: Journal Article

A Multi-method Approach to Psychiatric Genomics Consortium Cross-Disorder Analyses.

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Grotzinger A; Smoller J; Frei O; Werme J; de Leeuw C; Peyrot W
Publication Date: 2022-09-13
Type: Conference Proceeding

An In-Laboratory Stressor Reveals Unique Genetic Variation in Child Cortisol Output

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Raffington L; Malanchini M; Grotzinger AD; Madole JW; Engelhardt LE; Sabhlok A; Youn C; Patterson MW; Harden KP; Tucker-...
  • Raffington L
  • Malanchini M
  • Grotzinger AD
  • Madole JW
  • Engelhardt LE
  • Sabhlok A
  • Youn C
  • Patterson MW
  • Harden KP
  • Tucker-Drob EM
Published in: Developmental Psychology
Publication Date: 2022-06-30
Type: Journal Article

Developing Genomic SEM to Identify Sex Differences in the Multivariate Genetic Architecture of Psychiatric Disorders

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Schwaba T; Grotzinger AD; Nivard MG; Davis LK; Tucker-Drob EM
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2022-06-22
Type: Conference Proceeding

Using Genomic Structural Equation Modeling to Test the Validity of Latent Factor Models

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Clapp ML; Grotzinger AD; Tucker-Drob EM
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2022-06-22
Type: Conference Proceeding

Multivariate Modeling of Direct and Proxy GWAS Indicates Substantial Common Variant Heritability of Alzheimer's Disease

CU Boulder Authors: Grotzinger, Andrew David
All Authors: de la Fuente J; Grotzinger AD; Marioni RE; Nivard MG; Tucker-Drob EM
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2022-06-22
Type: Conference Proceeding

Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

CU Boulder Authors: Grotzinger, Andrew David; Keller, Matthew C
All Authors:
Mallard TT; Karlsson Linnér R; Grotzinger AD; Sanchez-Roige S; Seidlitz J; Okbay A; de Vlaming R; Meddens SFW; Palmer A...
  • Mallard TT
  • Karlsson Linnér R
  • Grotzinger AD
  • Sanchez-Roige S
  • Seidlitz J
  • Okbay A
  • de Vlaming R
  • Meddens SFW
  • Palmer AA
  • Davis LK
Publication Date: 2022-06-01
Type: Journal Article

Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer's disease outside of the APOE region

CU Boulder Authors: Grotzinger, Andrew David
All Authors: de la Fuente J; Grotzinger AD; Marioni RE; Nivard MG; Tucker-Drob EM
Published in: PLoS Genetics
Publication Date: 2022-06-01
Type: Journal Article

Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Grotzinger AD; Mallard TT; Akingbuwa WA; Ip HF; Adams MJ; Lewis CM; McIntosh AM; Grove J; Dalsgaard S; Lesch K-P...
  • Grotzinger AD
  • Mallard TT
  • Akingbuwa WA
  • Ip HF
  • Adams MJ
  • Lewis CM
  • McIntosh AM
  • Grove J
  • Dalsgaard S
  • Lesch K-P
Published in: Nature Genetics
Publication Date: 2022-05-05
Type: Journal Article

Genetic associations with learning over 100 days of practice

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Youn C; Grotzinger AD; Lill CM; Bertram L; Schmiedek F; Lovden M; Lindenberger U; Nivard M; Harden KP; Tucker-Drob EM...
  • Youn C
  • Grotzinger AD
  • Lill CM
  • Bertram L
  • Schmiedek F
  • Lovden M
  • Lindenberger U
  • Nivard M
  • Harden KP
  • Tucker-Drob EM
Published in: npj Science of Learning
Publication Date: 2022-05-04
Type: Journal Article

Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: A genomic structural equation modelling approach

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Bountress KE; Brick LA; Sheerin C; Grotzinger A; Bustamante D; Hawn SE; Gillespie N; Kirkpatrick RM; Kranzler H; Morey R...
  • Bountress KE
  • Brick LA
  • Sheerin C
  • Grotzinger A
  • Bustamante D
  • Hawn SE
  • Gillespie N
  • Kirkpatrick RM
  • Kranzler H
  • Morey R
Published in: Drug and Alcohol Dependence
Publication Date: 2022-05-01
Type: Journal Article

Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Mallard TT; Savage JE; Johnson EC; Huang Y; Edwards AC; Hottenga JJ; Grotzinger AD; Gustavson DE; Jennings M; Anokhin A...
  • Mallard TT
  • Savage JE
  • Johnson EC
  • Huang Y
  • Edwards AC
  • Hottenga JJ
  • Grotzinger AD
  • Gustavson DE
  • Jennings M
  • Anokhin A
Published in: American Journal of Psychiatry
Publication Date: 2022-01-01
Type: Journal Article

Shared genetic architecture across psychiatric disorders

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Grotzinger AD
Published in: Psychological Medicine
Publication Date: 2021-10-01
Type: Journal Article

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Linner RK; Mallard TT; Barr PB; Sanchez-Roige S; Madole JW; Driver MN; Poore HE; de Vlaming R; Grotzinger AD; Tielbeek J...
  • Linner RK
  • Mallard TT
  • Barr PB
  • Sanchez-Roige S
  • Madole JW
  • Driver MN
  • Poore HE
  • de Vlaming R
  • Grotzinger AD
  • Tielbeek JJ
Published in: Nature Neuroscience
Publication Date: 2021-08-26
Type: Journal Article

Triangulating Genetic Methods to Uncover the Contribution of Cognitive and Noncognitive Skills to Academic Achievement Throughout the School Years

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Malanchini M; Allegrini AG; Rimfeld K; Nivard MG; Biroli P; Cheesman R; von Stumm S; Demange PAD; van Bergen E; Grotzing...
  • Malanchini M
  • Allegrini AG
  • Rimfeld K
  • Nivard MG
  • Biroli P
  • Cheesman R
  • von Stumm S
  • Demange PAD
  • van Bergen E
  • Grotzinger AD
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2021-06-29
Type: Conference Proceeding

Symptom-level modelling unravels the shared genetic architecture of anxiety and depression

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Thorp JG; Campos AI; Grotzinger AD; Gerring ZF; An J; Ong J-S; Wang W; Shringarpure S; Byrne EM; MacGregor S...
  • Thorp JG
  • Campos AI
  • Grotzinger AD
  • Gerring ZF
  • An J
  • Ong J-S
  • Wang W
  • Shringarpure S
  • Byrne EM
  • MacGregor S
Published in: Nature Human Behaviour
Publication Date: 2021-04-15
Type: Journal Article

Adolescent Big Five Personality and Pubertal Development: Pubertal Hormone Concentrations and Self-Reported Pubertal Status

CU Boulder Authors: Grotzinger, Andrew David
All Authors: Van den Akker AL; Briley DA; Grotzinger AD; Tackett JL; Tucker-Drob EM; Harden KP
Published in: Developmental Psychology
Publication Date: 2021-01-01
Type: Journal Article

Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Demange PA; Malanchini M; Mallard TT; Biroli P; Cox SR; Grotzinger AD; Tucker-Drob EM; Abdellaoui A; Arseneault L; van B...
  • Demange PA
  • Malanchini M
  • Mallard TT
  • Biroli P
  • Cox SR
  • Grotzinger AD
  • Tucker-Drob EM
  • Abdellaoui A
  • Arseneault L
  • van Bergen E
Published in: Nature Genetics
Publication Date: 2021-01-01
Type: Journal Article

Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Brumpton B; Sanderson E; Heilbron K; Hartwig FP; Harrison S; Vie GÅ; Cho Y; Howe LD; Hughes A; Boomsma DI...
  • Brumpton B
  • Sanderson E
  • Heilbron K
  • Hartwig FP
  • Harrison S
  • Vie GÅ
  • Cho Y
  • Howe LD
  • Hughes A
  • Boomsma DI
Published in: Nature Communications
Publication Date: 2020-12-01
Type: Journal Article

A general dimension of genetic sharing across diverse cognitive traits inferred from molecular data

CU Boulder Authors: Grotzinger, Andrew David
All Authors: de la Fuente J; Davies G; Grotzinger AD; Tucker-Drob EM; Deary IJ
Published in: Nature Human Behaviour
Publication Date: 2020-09-07
Type: Journal Article

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Thorp JG; Campos AI; Grotzinger AD; Gerring Z; An J; Ong J-S; Wang W; Shringarpure S; Byrne EM; MacGregor S...
  • Thorp JG
  • Campos AI
  • Grotzinger AD
  • Gerring Z
  • An J
  • Ong J-S
  • Wang W
  • Shringarpure S
  • Byrne EM
  • MacGregor S
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2020-06-26
Type: Conference Proceeding

Genetic Associations Between Executive Functions and a General Factor of Psychopathology

CU Boulder Authors: Grotzinger, Andrew David
All Authors:
Harden KP; Engelhardt LE; Mann FD; Patterson MW; Grotzinger AD; Savicki SL; Thibodeaux ML; Freis SM; Tackett JL; Church ...
  • Harden KP
  • Engelhardt LE
  • Mann FD
  • Patterson MW
  • Grotzinger AD
  • Savicki SL
  • Thibodeaux ML
  • Freis SM
  • Tackett JL
  • Church JA
Published in: Journal of the American Academy of Child and Adolescent Psychiatry
Publication Date: 2020-06-01
Type: Journal Article

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