
Assistant Professor
Psychology & Neuroscience • Institute for Behavioral Genetics
Research Interests:
Multivariate genomic methods development and their application to psychiatric and cognitive traits.
Active Grants:
- NIA RF1 AG073593 (Tucker-Drob) 8/15/2021 – 7/31/2024 Large-scale Genomic Analysis of Aging-related Cognitive Change Prior to Dementia Onset. Role: Co-Investigator
- NIMH R01 MH120219 (Nivard & Tucker-Drob) 07/17/2020-04/30/2025 Dissecting the Multivariate Genetic Architecture of Psychiatric Diseases. Role: Co-Investigator
Current lab

Sophie Breunig
Predoctoral Trainee
Institute for Behavioral Genetics

Isabelle Foote
Postdoctoral Associate
Institute for Behavioral Genetics

Jeremy Lawrence
Predoctoral Trainee
Institute for Behavioral Genetics
Publications
Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis: A Simple Solution
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Grotzinger AD; de la Fuente J; Prive F; Nivard MG; Tucker-Drob EM
Published in: Biological PsychiatryPublication Date: 2023-01-01
Type: Journal Article
Potential bias in genetic correlations Mating patterns across two traits can inflate estimates of genetic overlap
CU Boulder Authors:
Grotzinger, Andrew David; Keller, Matthew C
All Authors:
Grotzinger AD; Keller MC
Published in: SciencePublication Date: 2022-11-18
Type: Journal Article
A Mixed-Methods Approach to Refining and Measuring the Construct of Positive Risk-Taking in Adolescence
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: Journal of Research on AdolescencePatterson MW; Pivnick L; Mann FD; Grotzinger AD; Monahan KC; Steinberg LD; Oosterhoff B; Tackett JL; Tucker-Drob EM; Har...
- Patterson MW
- Pivnick L
- Mann FD
- Grotzinger AD
- Monahan KC
- Steinberg LD
- Oosterhoff B
- Tackett JL
- Tucker-Drob EM
- Harden KP
Publication Date: 2022-11-10
Type: Journal Article
Transcriptome-wide and stratified genomic structural equation modeling identify neurobiological pathways shared across diverse cognitive traits
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Grotzinger AD; de la Fuente J; Davies G; Nivard MG; Tucker-Drob EM
Published in: Nature CommunicationsPublication Date: 2022-10-21
Type: Journal Article
A Multi-method Approach to Psychiatric Genomics Consortium Cross-Disorder Analyses.
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Grotzinger A; Smoller J; Frei O; Werme J; de Leeuw C; Peyrot W
Publication Date: 2022-09-13Type: Conference Proceeding
An In-Laboratory Stressor Reveals Unique Genetic Variation in Child Cortisol Output
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: Developmental PsychologyRaffington L; Malanchini M; Grotzinger AD; Madole JW; Engelhardt LE; Sabhlok A; Youn C; Patterson MW; Harden KP; Tucker-...
- Raffington L
- Malanchini M
- Grotzinger AD
- Madole JW
- Engelhardt LE
- Sabhlok A
- Youn C
- Patterson MW
- Harden KP
- Tucker-Drob EM
Publication Date: 2022-06-30
Type: Journal Article
Developing Genomic SEM to Identify Sex Differences in the Multivariate Genetic Architecture of Psychiatric Disorders
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Schwaba T; Grotzinger AD; Nivard MG; Davis LK; Tucker-Drob EM
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and manPublication Date: 2022-06-22
Type: Conference Proceeding
Using Genomic Structural Equation Modeling to Test the Validity of Latent Factor Models
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Clapp ML; Grotzinger AD; Tucker-Drob EM
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and manPublication Date: 2022-06-22
Type: Conference Proceeding
Multivariate Modeling of Direct and Proxy GWAS Indicates Substantial Common Variant Heritability of Alzheimer's Disease
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
de la Fuente J; Grotzinger AD; Marioni RE; Nivard MG; Tucker-Drob EM
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and manPublication Date: 2022-06-22
Type: Conference Proceeding
Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities
CU Boulder Authors:
Grotzinger, Andrew David; Keller, Matthew C
All Authors:
Publication Date: 2022-06-01Mallard TT; Karlsson Linnér R; Grotzinger AD; Sanchez-Roige S; Seidlitz J; Okbay A; de Vlaming R; Meddens SFW; Palmer A...
- Mallard TT
- Karlsson Linnér R
- Grotzinger AD
- Sanchez-Roige S
- Seidlitz J
- Okbay A
- de Vlaming R
- Meddens SFW
- Palmer AA
- Davis LK
Type: Journal Article
Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer's disease outside of the APOE region
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
de la Fuente J; Grotzinger AD; Marioni RE; Nivard MG; Tucker-Drob EM
Published in: PLoS GeneticsPublication Date: 2022-06-01
Type: Journal Article
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: Nature GeneticsGrotzinger AD; Mallard TT; Akingbuwa WA; Ip HF; Adams MJ; Lewis CM; McIntosh AM; Grove J; Dalsgaard S; Lesch K-P...
- Grotzinger AD
- Mallard TT
- Akingbuwa WA
- Ip HF
- Adams MJ
- Lewis CM
- McIntosh AM
- Grove J
- Dalsgaard S
- Lesch K-P
Publication Date: 2022-05-05
Type: Journal Article
Genetic associations with learning over 100 days of practice
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: npj Science of LearningYoun C; Grotzinger AD; Lill CM; Bertram L; Schmiedek F; Lovden M; Lindenberger U; Nivard M; Harden KP; Tucker-Drob EM...
- Youn C
- Grotzinger AD
- Lill CM
- Bertram L
- Schmiedek F
- Lovden M
- Lindenberger U
- Nivard M
- Harden KP
- Tucker-Drob EM
Publication Date: 2022-05-04
Type: Journal Article
Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: A genomic structural equation modelling approach
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: Drug and Alcohol DependenceBountress KE; Brick LA; Sheerin C; Grotzinger A; Bustamante D; Hawn SE; Gillespie N; Kirkpatrick RM; Kranzler H; Morey R...
- Bountress KE
- Brick LA
- Sheerin C
- Grotzinger A
- Bustamante D
- Hawn SE
- Gillespie N
- Kirkpatrick RM
- Kranzler H
- Morey R
Publication Date: 2022-05-01
Type: Journal Article
Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: American Journal of PsychiatryMallard TT; Savage JE; Johnson EC; Huang Y; Edwards AC; Hottenga JJ; Grotzinger AD; Gustavson DE; Jennings M; Anokhin A...
- Mallard TT
- Savage JE
- Johnson EC
- Huang Y
- Edwards AC
- Hottenga JJ
- Grotzinger AD
- Gustavson DE
- Jennings M
- Anokhin A
Publication Date: 2022-01-01
Type: Journal Article
Shared genetic architecture across psychiatric disorders
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Grotzinger AD
Published in: Psychological MedicinePublication Date: 2021-10-01
Type: Journal Article
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: Nature NeuroscienceLinner RK; Mallard TT; Barr PB; Sanchez-Roige S; Madole JW; Driver MN; Poore HE; de Vlaming R; Grotzinger AD; Tielbeek J...
- Linner RK
- Mallard TT
- Barr PB
- Sanchez-Roige S
- Madole JW
- Driver MN
- Poore HE
- de Vlaming R
- Grotzinger AD
- Tielbeek JJ
Publication Date: 2021-08-26
Type: Journal Article
Triangulating Genetic Methods to Uncover the Contribution of Cognitive and Noncognitive Skills to Academic Achievement Throughout the School Years
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and manMalanchini M; Allegrini AG; Rimfeld K; Nivard MG; Biroli P; Cheesman R; von Stumm S; Demange PAD; van Bergen E; Grotzing...
- Malanchini M
- Allegrini AG
- Rimfeld K
- Nivard MG
- Biroli P
- Cheesman R
- von Stumm S
- Demange PAD
- van Bergen E
- Grotzinger AD
Publication Date: 2021-06-29
Type: Conference Proceeding
Symptom-level modelling unravels the shared genetic architecture of anxiety and depression
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: Nature Human BehaviourThorp JG; Campos AI; Grotzinger AD; Gerring ZF; An J; Ong J-S; Wang W; Shringarpure S; Byrne EM; MacGregor S...
- Thorp JG
- Campos AI
- Grotzinger AD
- Gerring ZF
- An J
- Ong J-S
- Wang W
- Shringarpure S
- Byrne EM
- MacGregor S
Publication Date: 2021-04-15
Type: Journal Article
Adolescent Big Five Personality and Pubertal Development: Pubertal Hormone Concentrations and Self-Reported Pubertal Status
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Van den Akker AL; Briley DA; Grotzinger AD; Tackett JL; Tucker-Drob EM; Harden KP
Published in: Developmental PsychologyPublication Date: 2021-01-01
Type: Journal Article
Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: Nature GeneticsDemange PA; Malanchini M; Mallard TT; Biroli P; Cox SR; Grotzinger AD; Tucker-Drob EM; Abdellaoui A; Arseneault L; van B...
- Demange PA
- Malanchini M
- Mallard TT
- Biroli P
- Cox SR
- Grotzinger AD
- Tucker-Drob EM
- Abdellaoui A
- Arseneault L
- van Bergen E
Publication Date: 2021-01-01
Type: Journal Article
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: Nature CommunicationsBrumpton B; Sanderson E; Heilbron K; Hartwig FP; Harrison S; Vie GÅ; Cho Y; Howe LD; Hughes A; Boomsma DI...
- Brumpton B
- Sanderson E
- Heilbron K
- Hartwig FP
- Harrison S
- Vie GÅ
- Cho Y
- Howe LD
- Hughes A
- Boomsma DI
Publication Date: 2020-12-01
Type: Journal Article
A general dimension of genetic sharing across diverse cognitive traits inferred from molecular data
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
de la Fuente J; Davies G; Grotzinger AD; Tucker-Drob EM; Deary IJ
Published in: Nature Human BehaviourPublication Date: 2020-09-07
Type: Journal Article
Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and manThorp JG; Campos AI; Grotzinger AD; Gerring Z; An J; Ong J-S; Wang W; Shringarpure S; Byrne EM; MacGregor S...
- Thorp JG
- Campos AI
- Grotzinger AD
- Gerring Z
- An J
- Ong J-S
- Wang W
- Shringarpure S
- Byrne EM
- MacGregor S
Publication Date: 2020-06-26
Type: Conference Proceeding
Genetic Associations Between Executive Functions and a General Factor of Psychopathology
CU Boulder Authors:
Grotzinger, Andrew David
All Authors:
Published in: Journal of the American Academy of Child and Adolescent PsychiatryHarden KP; Engelhardt LE; Mann FD; Patterson MW; Grotzinger AD; Savicki SL; Thibodeaux ML; Freis SM; Tackett JL; Church ...
- Harden KP
- Engelhardt LE
- Mann FD
- Patterson MW
- Grotzinger AD
- Savicki SL
- Thibodeaux ML
- Freis SM
- Tackett JL
- Church JA
Publication Date: 2020-06-01
Type: Journal Article
Pages
Recruiting
Dr. Grotzinger plans to admit a graduate student for Fall 2023. Prospective students can apply through either the Behavioral, Psychiatric and Statistical Genetics (BPSG) area or the Clinical Area in Psychology and Neuroscience.
Prospective postdocs should contact Dr. Grotzinger directly.