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Get a front-row seat to the University of Colorado's next big ideas competing for $750,000

Get a front-row seat to the University of Colorado's next big ideas competing for $750,000

Eleven teams of University of Colorado entrepreneurs, faculty researchers and graduate student innovators will compete for a combined $750,000 in startup funding grants in this year’s Lab Venture Challenge (LVC) Showcases at the Dairy Arts Center. Judges from Venture Partners at CU Boulder’s entrepreneurial network will hear Shark Tank-style pitches across two nights, one for innovations in biosciences and another for physical sciences and engineering.

 

2025 Lab Venture Challenge Showcases

Physical Sciences: Wednesday, Oct. 22, 6 p.m.

Biosciences: Thursday, Oct. 23, 6 p.m.

Dairy Arts Center (2590 Walnut St, Boulder, CO 80302)

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Through LVC, top innovators from CU Boulder, Denver and Colorado Springs compete for grants of up to $125,000. LVC supports projects that address a commercial need, have a clear path to a compelling market and have strong scientific support. The LVC grants are funded by the Colorado Office of Economic Development and International Trade (OEDIT) Advanced Industries Program, as well as Venture Partners and the Chancellor’s Innovation Fund.

LVC is run by Venture Partners, one of the university’s commercialization arms and a central resource for researchers who wish to translate their work into impactful business and social ventures. LVC finalists are working and collaborating with Venture Partners on their path to commercialization.

“At this early stage, funding is essential, but can be a challenge to obtain,“ said Joshua Bennett, director of LVC and assistant director of licensing at Venture Partners. “All of these teams have promising innovations ready to launch new businesses. LVC is a unique opportunity for those innovators to receive that vital funding, and we’re proud to work with the State of Colorado to make it happen.”

To date, LVC has funded 117 projects through 64 new deep-tech startup companies, which collectively have raised over $349 million in follow-on financing including Darwin Biosciences, Manifest Technologies (prev. Vitro3D) and Mesa Quantum.

Members of the entrepreneurial and university communities are invited to attend the LVC Showcases to enjoy good food, network and see which teams will walk away with $125,000 of funding.

This year’s LVC showcases were additionally made possible by Berg Hill Greenleaf Ruscitti LLP, Johnson & Johnson, Holland & Hart LLP, Paralex and Thermo Fisher Scientific

2025 Physical Sciences Finalists

Breakthrough Analog Domain Jamming Suppression for UAVs

Multi-Domain Anti-Jamming Technology (MDAT) provides real-time interference suppression for military UAVs. With 400x size reduction via analog domain processing, MDAT deploys as 6x6-inch, sub-5lb plug-and-play modules for retrofitting tactical drones, ensuring mission continuity in contested RF environments. The team has formed BoldRF LLC to bring their innovation to market.

Magnetically Enhanced Electrolysis for H2 Production

Magnetically Enhanced Electrolysis (MEE) improves hydrogen generation efficiency by enhancing bubble release and energy transfer. Adapted from space technology, MEE offers scalable, cost-effective clean hydrogen for transportation, industry and off-grid power. The team has formed a startup, Agami Zero, to bring their innovation to market.

Novel Synergistic Catalysis for Clean Water and Fuel   

SynForce is developing a modular photo-thermo-catalysis device that rapidly activates a wide range of stubborn chemical bonds, enabling carbon-free fuel production at high reaction rates and the destruction of toxic PFAS in water, while reducing energy use and operating costs. The team has formed a startup, Synforce, to bring their innovation to market.

Next-Generation Holographic Materials for AR Displays

A thiol-ene holographic materials platform delivers low-haze, high-refractive-index photopolymers for sharper, more immersive AR displays. This versatile and scalable step-growth method overcomes shrinkage, scattering and supply-chain constraints of existing chain-growth materials for holographic optics.   

A Language-Driven Engine to Deploy Robots Like Software

BoBoRobo’s agentic AI engine turns plain English specifications into ready-to-deploy robotics—validated in a digital twin and safety-checked across OEMs. It outputs layout, BOM, install plan and robot-specific code, cutting deployment timelines from six months to ten days and reducing costs by up to 50%. The team has formed a startup, BoBoRobo, to bring their innovation to market.

Low SWaP Frequency Comb for Quantum applications

Our Gen-III low-SWaP frequency comb, built on thin-film lithium niobate nanophotonics, delivers octave-spanning spectra with ultra-low power. Compact, scalable and robust, it enables deployable quantum clocks, sensors and communication systems beyond the lab. The team has formed a startup,Chi3 Optics, to bring their innovation to market.

2025 Biosciences Finalists

Metabolite-Based Therapeutics for Obesity

Pythons exhibit dramatic metabolic plasticity with feeding, increasing organ size and activity by up to 40% after consuming large prey. From this biology, the team discovered a novel feeding-induced metabolite that was upregulated by 1,000-fold and acts as a natural appetite suppressant through modulating satiety. The team has formed a startup, Arkana Therapeutics, to bring their innovation to market.

Bioadhesive Patches That Seal Where Sutures Fail

DuraPatch provides rapid closure of cerebrospinal fluid (CSF) leaks during neurosurgery, eliminating the need for sutures. Engineered with high-resolution 3D printing and advanced biomaterials, DuraPatch strongly adheres to wet tissues to create a watertight seal while supporting and promoting healing. The team has founded a startup, Entangl3d, to bring their innovation to market.

Vaporizable Droplets for Proton Beam Visualization

Vaporizable exoskeletal droplets provide in vivo visualization of beam placement during proton therapy, a rapidly growing treatment approach for cancer. Using this image-guided therapy, clinicians can make real-time adjustments to the treatment, reducing harmful side effects and improving patient outcomes. The team has formed a startup, Radiosensitive VEDs, to bring their innovation to market.

Computationally Designed IL-18 binders to Treat Sepsis

Enabled by recent advances in AI-driven protein design, minibinders are being engineered to target IL-18, a key driver of sepsis. These compact, stable proteins penetrate tissues efficiently and can be precisely dosed to avoid prolonged immune suppression, offering a next-generation therapeutic for sepsis. The team has formed a startup, iMembrane Therapeutics, to bring their innovation to market.

Nanorobotic Synthesis of Oligonucleotides

Modern DNA synthesis suffers from low overall yields due to the accumulation of errors for longer strands. The team has designed a nanorobotic synthesis platform which can detect and correct errors during synthesis, enabling ultra-high fidelity synthesis of gene-length DNA for single-cell omics and genomics application. The team has formed a startup, Nanosynth, to bring their innovation to market.

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