
Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447
Research Interests:
The use of genetic strategies to identify the underlying biological bases for the behavioral and physiological actions of drugs of abuse with special emphasis on nicotine.
Active Grants:
- NIDA U01DA043802 (Stitzel, JA, Radcliffe, RA) 4/1/18-12/31/22. Genetic modifiers of Chrna5 deletion in mice: role in nicotine behaviors modulated by the medial habenula-IPN pathway. Role: PI
- NIDA R01DA044283 (Vrieze, S). Deep sequencing, phenotyping, and imputation in large-scale biobanks: a novel and cost-effective framework to identify rare mutations associated with addiction. Role: Co-investigator
Additional Resources:
Molecular Neurogenetics Laboratory
Current lab


Former Trainees
Jennifer Wilking
Doctoral student
2005-2009
Sheila Maier
Masters student
2006-2008
Tristan McClure-Begley
Doctoral student
2008-2010
Janessa Jacobs
Masters student
2008-2010
William Horton
Doctoral student
2009-2013
Hunter Mathews
Doctoral student
2014-2020
Jordan Buck
Doctoral student
2016-2020
Amanda Alvarado
Masters student
2017-2019
Xiao Li
Postdoctoral trainee
2002-2003
Sharon Mexal
Postdoctoral trainee
2005-2007
Tom Precht
Postdoctoral trainee
2008-2010
Anne Tammamaki
Postdoctoral trainee
2009-2012
Cristian Zambrano
Postdoctoral trainee
2009-2012, 2015-2017
Andre Zalud
Postdoctoral trainee
2011-2014
Rebecca Helfand
Postdoctoral trainee
2011-2014
Peter Dobelis
Postdoctoral trainee
2015-2017
Heidi O'Neill
Postdoctoral trainee
2015-2019
Genetic diversity fuels gene discovery for tobacco and alcohol use
Publication Date: 2022-12-22
Type: Journal Article
RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging
Publication Date: 2022-12-01
Type: Journal Article
Mutation of the?5 nicotinic acetylcholine receptor subunit increases ethanol and nicotine consumption in adolescence and impacts adult drug consumption
Publication Date: 2022-07-09
Type: Journal Article
An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions
Routhier J; Pons S; Freidja ML; Dalstein V; Cutrona J; Jonquet A; Lalun N; Merol J-C; Lathrop M; Stitzel JA...
- Routhier J
- Pons S
- Freidja ML
- Dalstein V
- Cutrona J
- Jonquet A
- Lalun N
- Merol J-C
- Lathrop M
- Stitzel JA
Publication Date: 2021-11-04
Type: Journal Article
Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice
Publication Date: 2021-11-04
Type: Journal Article
Testing Association of Previously Implicated Gene-Sets in Nicotine Exposed Mouse Models with Human Smoking Phenotypes
Publication Date: 2021-11-01
Type: Conference Proceeding
DNA methylome perturbations: an epigenetic basis for the emergingly heritable neurodevelopmental abnormalities associated with maternal smoking and maternal nicotine exposure
Publication Date: 2021-07-16
Type: Journal Article
The Intergenerational Transmission of Developmental Nicotine Exposure-Induced Neurodevelopmental Disorder-Like Phenotypes is Modulated by the Chrna5 D397N Polymorphism in Adolescent Mice
Publication Date: 2021-06-23
Type: Journal Article
Model-based assessment of replicability for genome-wide association meta-analysis
Publication Date: 2021-03-30
Type: Journal Article
The Role of A Priori-Identified Addiction and Smoking Gene Sets in Smoking Behaviors
Evans LM; Johnson EC; Melroy-Greif WE; Hewitt JK; Hoeffer CA; Keller MC; Saba LM; Stitzel JA; Ehringer MA...
- Evans LM
- Johnson EC
- Melroy-Greif WE
- Hewitt JK
- Hoeffer CA
- Keller MC
- Saba LM
- Stitzel JA
- Ehringer MA
Publication Date: 2020-08-01
Type: Journal Article
Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice
Publication Date: 2020-03-05
Type: Journal Article
Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice
Publication Date: 2019-10-01
Type: Journal Article
Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice
Publication Date: 2019-05-01
Type: Journal Article
The effects of oral nicotine administration and abstinence on sleep in male C57BL/6J mice
Publication Date: 2019-04-01
Type: Journal Article
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Publication Date: 2019-02-01
Type: Journal Article
Serine residues in the alpha 4 nicotinic acetylcholine receptor subunit regulate surface alpha 4 beta 2(star) receptor expression and clustering
Publication Date: 2019-01-01
Type: Journal Article
A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction
Coverstone ED; Bach RG; Chen L; Bierut LJ; Li AY; Lenzini PA; O'Neill HC; Spertus JA; Sucharov CC; Stitzel JA...
- Coverstone ED
- Bach RG
- Chen L
- Bierut LJ
- Li AY
- Lenzini PA
- O'Neill HC
- Spertus JA
- Sucharov CC
- Stitzel JA
Publication Date: 2018-09-01
Type: Journal Article
The interaction of the Chrna5 D398N variant with developmental nicotine exposure
Publication Date: 2018-09-01
Type: Journal Article
CYP2A6 metabolism in the development of smoking behaviors in young adults
Olfson E; Bloom J; Bertelsen S; Budde JP; Breslau N; Brooks A; Culverhouse R; Chan G; Chen L-S; Chorlian D...
- Olfson E
- Bloom J
- Bertelsen S
- Budde JP
- Breslau N
- Brooks A
- Culverhouse R
- Chan G
- Chen L-S
- Chorlian D
Publication Date: 2018-01-01
Type: Journal Article
Maternal nicotine exposure elicits multigenerational nicotine preference and sex-specific behavioral anomalies in adolescent mice
Type: Conference Proceeding
Nicotine administration and withdrawal alters sleep and prepro-hypocretin levels in mice
Type: Conference Proceeding
Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis
Publication Date: 2017-09-01
Type: Journal Article
DIFFERENCES IN ACUTE LOCOMOTOR ACTIVATION TO ALCOHOL IN D397N MICE, A MODEL OF THE HUMAN CHRNA5 NICOTINIC ACETYLCHOLINE POLYMORPHISM (RS16969989)
Publication Date: 2017-06-24
Type: Conference Proceeding
NICOTINE ADMINISTRATION AND WITHDRAWAL ALTERS SLEEP AND PREPRO-OREXIN LEVELS IN MICE
Publication Date: 2017-06-03
Type: Conference Proceeding
Examining the interaction between in utero nicotine exposure and the D397N CHRNA5 nicotinic acetylcholine polymorphism (rs16969968) on alcohol intake in mice.
Type: Conference Proceeding
Pages
Recruiting
The Stitzel lab is not currently recruiting students or postdocs.