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Jerry Stitzel

Professor

Institute for Behavioral Genetics • Integrative Physiology

stitzel@colorado.edu

303-735-6173

Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447

Research Interests:

The use of genetic strategies to identify the underlying biological bases for the behavioral and physiological actions of drugs of abuse with special emphasis on nicotine.

Active Grants:

NIDA U01DA043802 (Stitzel, JA, Radcliffe, RA) 4/1/18-12/31/22. Genetic modifiers of Chrna5 deletion in mice: role in nicotine behaviors modulated by the medial habenula-IPN pathway. Role: PI
NIDA R01DA044283 (Vrieze, S). Deep sequencing, phenotyping, and imputation in large-scale biobanks: a novel and cost-effective framework to identify rare mutations associated with addiction. Role: Co-investigator

Additional Resources:

Molecular Neurogenetics Laboratory

Listen to Dr. Stitzel speak

Dr. Stitzel speaks on Molecular Genetics:

Current lab

Sidney Aki

Predoctoral Trainee

Integrative Physiology

Hunter Mathews

Research Associate

Institute for Behavioral Genetics

Former Trainees

Jennifer Wilking

Doctoral student

2005-2009

Sheila Maier

Masters student

2006-2008

Tristan McClure-Begley

Doctoral student

2008-2010

Janessa Jacobs

Masters student

2008-2010

William Horton

Doctoral student

2009-2013

Hunter Mathews

Doctoral student

2014-2020

Jordan Buck

Doctoral student

2016-2020

Amanda Alvarado

Masters student

2017-2019

Xiao Li

Postdoctoral trainee

2002-2003

Sharon Mexal

Postdoctoral trainee

2005-2007

Tom Precht

Postdoctoral trainee

2008-2010

Anne Tammamaki

Postdoctoral trainee

2009-2012

Cristian Zambrano

Postdoctoral trainee

2009-2012, 2015-2017

Andre Zalud

Postdoctoral trainee

2011-2014

Rebecca Helfand

Postdoctoral trainee

2011-2014

Peter Dobelis

Postdoctoral trainee

2015-2017

Heidi O'Neill

Postdoctoral trainee

2015-2019

Publications

Google Scholar

Genetic diversity fuels gene discovery for tobacco and alcohol use

CU Boulder Authors: Keller, Matthew C; Krauter, Kenneth S; Stitzel, Jerry A; Boardman, Jason D; Hewitt, John K

All Authors: Saunders GRB; Wang X; Chen F; Jang S-K; Liu M; Wang C; Gao S; Jiang Y; Khunsriraksakul C; Otto JM

Published in: Nature
Publication Date: 2022-12-22
Type: Journal Article

RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging

CU Boulder Authors: Hoeffer, Charles Albert; Stitzel, Jerry A

All Authors: Wong H; Buck JM; Borski C; Pafford JT; Keller BN; Milstead RA; Hanson JL; Stitzel JA; Hoeffer CA

Published in: Journal of Neurodevelopmental Disorders
Publication Date: 2022-12-01
Type: Journal Article

Mutation of the?5 nicotinic acetylcholine receptor subunit increases ethanol and nicotine consumption in adolescence and impacts adult drug consumption

CU Boulder Authors: Stitzel, Jerry A

All Authors: Carde NAQ; Shaw J; Carter C; Kim S; Stitzel JA; Venkatesh SK; Ramchandani VA; De Biasi M

Published in: Neuropharmacology
Publication Date: 2022-07-09
Type: Journal Article

An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions

CU Boulder Authors: Stitzel, Jerry A

All Authors:

Routhier J; Pons S; Freidja ML; Dalstein V; Cutrona J; Jonquet A; Lalun N; Merol J-C; Lathrop M; Stitzel JA...

Routhier J
Pons S
Freidja ML
Dalstein V
Cutrona J
Jonquet A
Lalun N
Merol J-C
Lathrop M
Stitzel JA

Published in: Nature Communications
Publication Date: 2021-11-04
Type: Journal Article

Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice

CU Boulder Authors: Stitzel, Jerry A

All Authors: Meyers E; Werner Z; Wichman D; Mathews HL; Radcliffe RA; Nadeau JH; Stitzel JA

Published in: Frontiers in Psychiatry
Publication Date: 2021-11-04
Type: Journal Article

Testing Association of Previously Implicated Gene-Sets in Nicotine Exposed Mouse Models with Human Smoking Phenotypes

CU Boulder Authors: Ehringer, Marissa A; Evans, Luke M.; Stitzel, Jerry A

All Authors: Mize TJ; Funkhouser SA; Buck JM; Stitzel JA; Ehringer MA; Evans LM

Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2021-11-01
Type: Conference Proceeding

DNA methylome perturbations: an epigenetic basis for the emergingly heritable neurodevelopmental abnormalities associated with maternal smoking and maternal nicotine exposure

CU Boulder Authors: Stitzel, Jerry A

All Authors: Buck JM; Yu L; Knopik VS; Stitzel JA

Published in: Biology of Reproduction
Publication Date: 2021-07-16
Type: Journal Article

The Intergenerational Transmission of Developmental Nicotine Exposure-Induced Neurodevelopmental Disorder-Like Phenotypes is Modulated by the Chrna5 D397N Polymorphism in Adolescent Mice

CU Boulder Authors: Stitzel, Jerry A

All Authors: Buck JM; O'Neill HC; Stitzel JA

Published in: Behavior Genetics: an international journal devoted to research in the inheritance of behavior in animals and man
Publication Date: 2021-06-23
Type: Journal Article

Model-based assessment of replicability for genome-wide association meta-analysis

CU Boulder Authors: Krauter, Kenneth S; Ehringer, Marissa A; Stitzel, Jerry A

All Authors: McGuire D; Jiang Y; Liu M; Weissenkampen JD; Eckert S; Yang L; Chen F; Liu M; Jiang Y; Wedow R

Published in: Nature Communications
Publication Date: 2021-03-30
Type: Journal Article

The Role of A Priori-Identified Addiction and Smoking Gene Sets in Smoking Behaviors

CU Boulder Authors: Keller, Matthew C; Stitzel, Jerry A; Evans, Luke M.; Hewitt, John K; Ehringer, Marissa A; Hoeffer, Charles Albert

All Authors:

Evans LM; Johnson EC; Melroy-Greif WE; Hewitt JK; Hoeffer CA; Keller MC; Saba LM; Stitzel JA; Ehringer MA...

Evans LM
Johnson EC
Melroy-Greif WE
Hewitt JK
Hoeffer CA
Keller MC
Saba LM
Stitzel JA
Ehringer MA

Published in: Nicotine and Tobacco Research
Publication Date: 2020-08-01
Type: Journal Article

Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice

CU Boulder Authors: Stitzel, Jerry A

All Authors: Buck JM; O'Neill HC; Stitzel JA

Published in: Epigenetics and Chromatin
Publication Date: 2020-03-05
Type: Journal Article

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice

CU Boulder Authors: Stitzel, Jerry A

All Authors: Buck JM; O'Neill HC; Stitzel JA

Published in: Biochemical Pharmacology
Publication Date: 2019-10-01
Type: Journal Article

Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice

CU Boulder Authors: Stitzel, Jerry A

All Authors: Buck JM; Sanders KN; Wageman CR; Knopik VS; Stitzel JA; O'Neill HC

Published in: Neuropharmacology
Publication Date: 2019-05-01
Type: Journal Article

The effects of oral nicotine administration and abstinence on sleep in male C57BL/6J mice

CU Boulder Authors: Stitzel, Jerry A

All Authors: Mathews HL; Stitzel JA

Published in: Psychopharmacology
Publication Date: 2019-04-01
Type: Journal Article

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

CU Boulder Authors: McQueen, Matt; Boardman, Jason D; Stitzel, Jerry A; Keller, Matthew C; Hewitt, John K; Stallings, Michael C; Ehringer, Marissa A; Krauter, Kenneth S

All Authors: Liu M; Jiang Y; Wedow R; Li Y; Brazel DM; Chen F; Datta G; Davila-Velderrain J; McGuire D; Tian C

Published in: Nature Genetics
Publication Date: 2019-02-01
Type: Journal Article

Serine residues in the alpha 4 nicotinic acetylcholine receptor subunit regulate surface alpha 4 beta 2(star) receptor expression and clustering

CU Boulder Authors: Stitzel, Jerry A

All Authors: Zambrano CA; Escobar D; Ramos-Santiago T; Bollinger I; Stitzel J

Published in: Biochemical Pharmacology
Publication Date: 2019-01-01
Type: Journal Article

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction

CU Boulder Authors: Stitzel, Jerry A

All Authors:

Coverstone ED; Bach RG; Chen L; Bierut LJ; Li AY; Lenzini PA; O'Neill HC; Spertus JA; Sucharov CC; Stitzel JA...

Coverstone ED
Bach RG
Chen L
Bierut LJ
Li AY
Lenzini PA
O'Neill HC
Spertus JA
Sucharov CC
Stitzel JA

Published in: Basic Research in Cardiology
Publication Date: 2018-09-01
Type: Journal Article

The interaction of the Chrna5 D398N variant with developmental nicotine exposure

CU Boulder Authors: Stitzel, Jerry A

All Authors: O'Neill HC; Wageman CR; Sherman SE; Grady SR; Marks MJ; Stitzel JA

Published in: Genes, Brain and Behavior
Publication Date: 2018-09-01
Type: Journal Article

CYP2A6 metabolism in the development of smoking behaviors in young adults

CU Boulder Authors: Stitzel, Jerry A

All Authors:

Olfson E; Bloom J; Bertelsen S; Budde JP; Breslau N; Brooks A; Culverhouse R; Chan G; Chen L-S; Chorlian D...

Olfson E
Bloom J
Bertelsen S
Budde JP
Breslau N
Brooks A
Culverhouse R
Chan G
Chen L-S
Chorlian D

Published in: Addiction Biology
Publication Date: 2018-01-01
Type: Journal Article

Maternal nicotine exposure elicits multigenerational nicotine preference and sex-specific behavioral anomalies in adolescent mice

CU Boulder Authors: Stitzel, Jerry A

All Authors: Buck JM; O'Neill HC; STITZEL JA

Publication Date: 2017-11-13
Type: Conference Proceeding

Nicotine administration and withdrawal alters sleep and prepro-hypocretin levels in mice

CU Boulder Authors: Stitzel, Jerry A

All Authors: Mathews HL; Ahmad S; STITZEL JA

Publication Date: 2017-11-11
Type: Conference Proceeding

Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis

CU Boulder Authors: Stitzel, Jerry A

All Authors: Bai X; Stitzel JA; Bai A; Zambrano CA; Phillips M; Marrack P; Chan ED

Published in: American Journal of Respiratory Cell and Molecular Biology
Publication Date: 2017-09-01
Type: Journal Article

DIFFERENCES IN ACUTE LOCOMOTOR ACTIVATION TO ALCOHOL IN D397N MICE, A MODEL OF THE HUMAN CHRNA5 NICOTINIC ACETYLCHOLINE POLYMORPHISM (RS16969989)

CU Boulder Authors: Ehringer, Marissa A; Stitzel, Jerry A

All Authors: Powers MS; Dykstal KO; Stitzel JA; Ehringer MA

Published in: Alcoholism: Clinical and Experimental Research
Publication Date: 2017-06-24
Type: Conference Proceeding

NICOTINE ADMINISTRATION AND WITHDRAWAL ALTERS SLEEP AND PREPRO-OREXIN LEVELS IN MICE

CU Boulder Authors: Stitzel, Jerry A

All Authors: Mathews HL; Jimenez L; Ahmad S; Stitzel JA

Published in: Sleep
Publication Date: 2017-06-03
Type: Conference Proceeding

Examining the interaction between in utero nicotine exposure and the D397N CHRNA5 nicotinic acetylcholine polymorphism (rs16969968) on alcohol intake in mice.

CU Boulder Authors: Stitzel, Jerry A; Ehringer, Marissa A

All Authors: Powers MS; O'Neill HC; STITZEL JA; Ehringer MA

Publication Date: 2017-05-12
Type: Conference Proceeding

Recruiting

The Stitzel lab is not currently recruiting students or postdocs.

Highlighted Publications

Schematic of the breeding strategy used to generate CSS possessing the Chrna5 null mutation

Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice

In this study, we used Chrna5 knockout mice bred onto a panel of chromosome substitution strains to determine whether there might be genes that can alter the effect of Chrna5 on nicotine consumption. Results indicated that there are likely several genes that can eliminate the effect of Chrna5 deletion on nicotine consumption as well as genes that affect nicotine consumption independent of Chrna5. Because CHRNA5 is associated with nicotine dependence in humans, identification of these Chrna5 modifiers may lead to novel targets for the development of smoking cessation aids.

(Frontiers in Psychiatry, 2021)

Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice

We previously demonstrated that in utero nicotine exposure leads to neurodevelopmental disorder-like behaviors (ADHD, schizophrenia, autism, etc.) and altered brain biochemistry in both the directly in utero-exposed offspring and the unexposed grand-offspring. This study identified changes in several epigenetic factors which may explain the multi-generational effect of in utero nicotine exposure on behavior and brain biochemistry.

(Epigenetics & Chromatin, 2020)

Average (n = 9; ± SEM) active phase sleep latency across treatment periods

The effects of oral nicotine administration and abstinence on sleep in male C57BL/6J mice

This study was the first study to assess the effect of nicotine withdrawal in an animal model. Results indicated that nicotine withdrawal had little effect on overall sleep time but did lead to sleep fragmentation, a measure indicative of poor sleep quality. These findings are similar to the effect of nicotine withdrawal in humans.

(Psychopharmacology, 2019)

125I-Epibatidine binding in striatal membranes

The interaction of the Chrna5 D398N variant with developmental nicotine exposure

This paper describes a series of experiments that demonstrate that the effect of in utero and early post-natal nicotine exposure on adolescent nicotine consumption and striatal dopamine release are impacted by a genetic variant in the nicotinic acetylcholine receptor gene Chrna5. Following developmental nicotine exposure, mice possessing a "risk' variant for nicotine consumption increased nicotine consumption and exhibited reduced striatal dopamine release following developmental nicotine exposure while mice possessing the "non-risk" variant showed substantially reduced nicotine consumption and increased striatal dopamine release. These results suggest that nicotine consumption behavior and brain function are influenced by both genetics and environmental exposures.

(Genes, Brain, and Behavior, 2018)

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People at IBG

Jerry Stitzel

Research Interests:

Active Grants:

Additional Resources:

Current lab

Former Trainees

Jennifer Wilking

Sheila Maier

Tristan McClure-Begley

Janessa Jacobs

William Horton

Hunter Mathews

Jordan Buck

Amanda Alvarado

Xiao Li

Sharon Mexal

Tom Precht

Anne Tammamaki

Cristian Zambrano

Andre Zalud

Rebecca Helfand

Peter Dobelis

Heidi O'Neill

Publications

Testing Association of Previously Implicated Gene-Sets in Nicotine Exposed Mouse Models with Human Smoking Phenotypes

Maternal nicotine exposure elicits multigenerational nicotine preference and sex-specific behavioral anomalies in adolescent mice

Nicotine administration and withdrawal alters sleep and prepro-hypocretin levels in mice

DIFFERENCES IN ACUTE LOCOMOTOR ACTIVATION TO ALCOHOL IN D397N MICE, A MODEL OF THE HUMAN CHRNA5 NICOTINIC ACETYLCHOLINE POLYMORPHISM (RS16969989)

Examining the interaction between in utero nicotine exposure and the D397N CHRNA5 nicotinic acetylcholine polymorphism (rs16969968) on alcohol intake in mice.

Pages

Recruiting

Highlighted Publications