Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447
Research Interests:
The use of genetic strategies to identify the underlying biological bases for the behavioral and physiological actions of drugs of abuse with special emphasis on nicotine.
Active Grants:
- NIDA U01DA043802 (Stitzel, JA, Radcliffe, RA) 4/1/18-12/31/22. Genetic modifiers of Chrna5 deletion in mice: role in nicotine behaviors modulated by the medial habenula-IPN pathway. Role: PI
- NIDA R01DA044283 (Vrieze, S). Deep sequencing, phenotyping, and imputation in large-scale biobanks: a novel and cost-effective framework to identify rare mutations associated with addiction. Role: Co-investigator
-
AB Nexus Grant (Stitzel, Patel MPI). Multi-generation impact of developmental nicotine exposure on mitochondrial function. Role: Lead PI
Additional Resources:
Molecular Neurogenetics Laboratory
Current lab
Former Trainees
Jennifer Wilking
Doctoral student
2005-2009
Sheila Maier
Masters student
2006-2008
Tristan McClure-Begley
Doctoral student
2008-2010
Janessa Jacobs
Masters student
2008-2010
William Horton
Doctoral student
2009-2013
Hunter Mathews
Doctoral student
2014-2020
Jordan Buck
Doctoral student
2016-2020
Amanda Alvarado
Masters student
2017-2019
Xiao Li
Postdoctoral trainee
2002-2003
Sharon Mexal
Postdoctoral trainee
2005-2007
Tom Precht
Postdoctoral trainee
2008-2010
Anne Tammamaki
Postdoctoral trainee
2009-2012
Cristian Zambrano
Postdoctoral trainee
2009-2012, 2015-2017
Andre Zalud
Postdoctoral trainee
2011-2014
Rebecca Helfand
Postdoctoral trainee
2011-2014
Peter Dobelis
Postdoctoral trainee
2015-2017
Heidi O'Neill
Postdoctoral trainee
2015-2019
Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits
Publication Date: 2023-05-01
Type: Journal Article
Genetic diversity fuels gene discovery for tobacco and alcohol use
Publication Date: 2022-12-22
Type: Journal Article
RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging
Publication Date: 2022-12-01
Type: Journal Article
Testing Association of Previously Implicated Gene Sets and Gene-Networks in Nicotine Exposed Mouse Models with Human Smoking Phenotypes
Publication Date: 2022-11-29
Type: Journal Article
Mutation of the?5 nicotinic acetylcholine receptor subunit increases ethanol and nicotine consumption in adolescence and impacts adult drug consumption
Publication Date: 2022-07-09
Type: Journal Article
An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions
Routhier J; Pons S; Freidja ML; Dalstein V; Cutrona J; Jonquet A; Lalun N; Merol J-C; Lathrop M; Stitzel JA...
- Routhier J
- Pons S
- Freidja ML
- Dalstein V
- Cutrona J
- Jonquet A
- Lalun N
- Merol J-C
- Lathrop M
- Stitzel JA
Publication Date: 2021-11-04
Type: Journal Article
Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice
Publication Date: 2021-11-04
Type: Journal Article
The Intergenerational Transmission of Developmental Nicotine Exposure-Induced Neurodevelopmental Disorder-Like Phenotypes is Modulated by the Chrna5 D397N Polymorphism in Adolescent Mice
Publication Date: 2021-11-01
Type: Journal Article
DNA methylome perturbations: an epigenetic basis for the emergingly heritable neurodevelopmental abnormalities associated with maternal smoking and maternal nicotine exposure
Publication Date: 2021-09-01
Type: Journal Article
Model-based assessment of replicability for genome-wide association meta-analysis
Publication Date: 2021-03-30
Type: Journal Article
The Role of A Priori-Identified Addiction and Smoking Gene Sets in Smoking Behaviors
Evans LM; Johnson EC; Melroy-Greif WE; Hewitt JK; Hoeffer CA; Keller MC; Saba LM; Stitzel JA; Ehringer MA...
- Evans LM
- Johnson EC
- Melroy-Greif WE
- Hewitt JK
- Hoeffer CA
- Keller MC
- Saba LM
- Stitzel JA
- Ehringer MA
Publication Date: 2020-08-01
Type: Journal Article
Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice
Publication Date: 2020-03-05
Type: Journal Article
Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice
Publication Date: 2019-10-01
Type: Journal Article
Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice
Publication Date: 2019-05-01
Type: Journal Article
The effects of oral nicotine administration and abstinence on sleep in male C57BL/6J mice
Publication Date: 2019-04-01
Type: Journal Article
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Publication Date: 2019-02-01
Type: Journal Article
Serine residues in the α4 nicotinic acetylcholine receptor subunit regulate surface α4β2☆ receptor expression and clustering
Publication Date: 2019-01-01
Type: Journal Article
A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction
Coverstone ED; Bach RG; Chen L; Bierut LJ; Li AY; Lenzini PA; O'Neill HC; Spertus JA; Sucharov CC; Stitzel JA...
- Coverstone ED
- Bach RG
- Chen L
- Bierut LJ
- Li AY
- Lenzini PA
- O'Neill HC
- Spertus JA
- Sucharov CC
- Stitzel JA
Publication Date: 2018-09-01
Type: Journal Article
The interaction of the Chrna5 D398N variant with developmental nicotine exposure
Publication Date: 2018-09-01
Type: Journal Article
CYP2A6 metabolism in the development of smoking behaviors in young adults
Olfson E; Bloom J; Bertelsen S; Budde JP; Breslau N; Brooks A; Culverhouse R; Chan G; Chen L-S; Chorlian D...
- Olfson E
- Bloom J
- Bertelsen S
- Budde JP
- Breslau N
- Brooks A
- Culverhouse R
- Chan G
- Chen L-S
- Chorlian D
Publication Date: 2018-01-01
Type: Journal Article
Maternal nicotine exposure elicits multigenerational nicotine preference and sex-specific behavioral anomalies in adolescent mice
Type: Conference Proceeding
Nicotine administration and withdrawal alters sleep and prepro-hypocretin levels in mice
Type: Conference Proceeding
Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis
Publication Date: 2017-09-01
Type: Journal Article
DIFFERENCES IN ACUTE LOCOMOTOR ACTIVATION TO ALCOHOL IN D397N MICE, A MODEL OF THE HUMAN CHRNA5 NICOTINIC ACETYLCHOLINE POLYMORPHISM (RS16969989)
Publication Date: 2017-06-24
Type: Conference Proceeding
NICOTINE ADMINISTRATION AND WITHDRAWAL ALTERS SLEEP AND PREPRO-OREXIN LEVELS IN MICE
Publication Date: 2017-06-03
Type: Conference Proceeding
Pages
Recruiting
Dr. Stitzel is recruiting new students for a fall 2025 start date. Applications are typically due mid November; for exact dates please check the Department of Integrative Physiology website, if you intend to work with Dr. Stitzel. Additional information is available on IBG's Prospective Students page.
The Stitzel lab is not currently recruiting postdocs.