LOC110117498-PIK3R3

Nicotine Gene Report Key

N = No/insufficient data. Will be updated as they become available.

- = Data have been collected, but there is weak support for the gene. Included in network

+ = Moderate support for the gene.

++ = Strong support for the gene.

Default thresholds (-,+,++) differ by data type and are defined once you click on the link for more detail. Thresholds for each item and weighting of each item for overall priority score can be adjusted by the user.

SNP level association from available GWAS data
Smoking Initiation () Data	Age of smoking initiation () Data	Cigarettes per day () Data	Smoking cessation () Data

Gene level association based on results from available GWAS data
Smoking Initiation () Data	Age of smoking initiation () Data	Cigarettes per day () Data	Smoking cessation () Data

Human Studies Regulatory Evidence	Key
TWAS (any tissue) Data
TWAS (brain tissue) Data
TWAS (any tissue) Data
TWAS (dlPFC) Data
TWAS (NAcc) Data
COLOC/MR Data
Data
mRNA differences Data
eQTL Data
Methylation differences Data
Implicated miRNA target Data

Within a QTL for a nicotine phenotype (P2 and other studies)
Acute Sensitivity () Data	Reward () Data	Consumption () Data	Withdrawal () Data	Other () Data

Within a QTL for other addiction-related phenotypes
Behavioral () Data	Other drug of abuse () Data

Mouse Regulatory Evidence	Key
TWAS (DIPFC) Data
TWAS (NACC) Data
Included in network Data
mRNA differences Data
eQTL Data
Methylation differences Data
Implicated miRNA target Data

Mouse Models	Key
One or more model is available and lives Data
Evidence for nicotine phenotype Data
Evidence for drug-related behavioral phenotype (e.g. anxiety) Data
Evidence for other phenotype D (e.g. metabolism, heart rate) Data

Target Drug ()

Data

Conservation of DNA/mRNA.exon use between humans/mice ()

Data

Human/mouse brain expression pattern similarity ()

Data

Human/mouse cell-type specific expression ()

Data

Gene similarity clustering evidence ()

Data

Search

Other ways to search:

LOC110117498-PIK3R3

Nicotine Gene Report Key