WDR90

Nicotine Gene Report Key

N = No/insufficient data. Will be updated as they become available.

- = Data have been collected, but there is weak support for the gene. Included in network

+ = Moderate support for the gene.

++ = Strong support for the gene.

Default thresholds (-,+,++) differ by data type and are defined once you click on the link for more detail. Thresholds for each item and weighting of each item for overall priority score can be adjusted by the user.

Within a QTL for a nicotine phenotype (P2 and other studies)
Acute Sensitivity () Data	Reward () Data	Consumption () Data	Withdrawal () Data

Within a QTL for other addiction-related phenotypes
Behavioral () Data	Other drug of abuse () Data

Mouse Regulatory Evidence	Key
TWAS (DIPFC) Data
TWAS (NACC) Data
Included in network Data
mRNA differences Data
eQTL Data
Methylation differences Data
Implicated miRNA target Data

Mouse Models	Key
One or more model is available and lives Data
Evidence for nicotine phenotype Data
Evidence for drug-related behavioral phenotype (e.g. anxiety) Data
Evidence for other phenotype D (e.g. metabolism, heart rate) Data

Other Characteristics

Target Drug ()

Drug Bank

Conservation of DNA/mRNA.exon use between humans/mice ()

Data

Human/mouse brain expression pattern similarity ()

Data

Human/mouse cell-type specific expression ()

Data

Gene similarity clustering evidence ()

Data

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WDR90

Nicotine Gene Report Key

Other Characteristics