
Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447
Research Interests:
Developing models to understand complex trait genetics. Using family-based GWAS datasets to estimate direct genetic effects and the environmental influences of parents on offspring. Modeling and simulating genetically informative designs that better enable us to understand the causes of human differences.
Active Grants:
- NIMH R01 MH130448 7/2022-6/2027 Causes and consequences of mental disorders: The environmental and genetic influences of parents on offspring. Role: Principal investigator
- NIMH 2R01 MH100141 2/2013-4/2023 Estimating the genetic and environmental architecture of psychiatric disorders. Role: Principal investigator
- NIMH R25 MH019918 2/2024-1/2029 Workshop on statistical genetic methods for human complex traits. Role: Principal investigator
- NIDA R01 DA054087 5/1/2022 – 4/30/2027 Understanding the links between parental and adolescent substance use: complementary natural experiments using the children of twins design. Role: Co-Principal investigator
- NIDA R01 DA046064 4/2018-1/2023 Brain and genetic predictors of individual differences in pain and placebo analgesia. Role: Co-investigator
- NIDA R01 DA044283 5/2019 – 2/2024 Deep sequencing, phenotyping, and imputation in large-scale biobanks: A novel and cost-effective framework to identify rare mutations associated with addiction. Role: Principal investigator of subcontract
- NIDA R01 DA053693 4/2024 – 3/2028 Adult Progression of Adolescent Onset Substance Use Disorder in a High Risk Sample. Role: Co-investigator
Additional Resources:
Current Lab






Former Trainees
Spencer Moore
Masters student
2020-2022
Jared Balbona
Doctoral student
2018-2022
Richard Border
Doctoral student
2014-2019
Emma Johnson
Doctoral student
2012-2017
Teresa de Candia
Doctoral student
2011-2015
Matthew Simonson
Doctoral student
2008-2013
Dan Howrigan
Doctoral student
2008-2012
Laramie Duncan
Doctoral student
2008-2010
Subrata Paul
Postdoctoral trainee
2020-2021
Meng Huang
Postdoctoral trainee
2020-2021
Rasool Tahmasbi
Postdoctoral trainee
2015-2018
Luke Evans
Postdoctoral trainee
2015-2018
Doug Bjelland
Postdoctoral trainee
2013-2016
Christine Garver-Apgar
Postdoctoral trainee
2008-2011
Candidate Gene-Environment Interaction Research: Reflections and Recommendations
Publication Date: 2015-01-01
Type: Journal Article
The Association of Genotype-Based Inbreeding Coefficient with a Range of Physical and Psychological Human Traits
Publication Date: 2014-07-25
Type: Journal Article
Biological insights from 108 schizophrenia-associated genetic loci
Ripke S; Neale BM; Corvin A; Walters JTR; Farh K-H; Holmans PA; Lee P; Bulik-Sullivan B; Collier DA; Huang H...
- Ripke S
- Neale BM
- Corvin A
- Walters JTR
- Farh K-H
- Holmans PA
- Lee P
- Bulik-Sullivan B
- Collier DA
- Huang H
Publication Date: 2014-07-24
Type: Journal Article
Large-scale genomics unveils the genetic architecture of psychiatric disorders
Publication Date: 2014-06-01
Type: Journal Article
Estimating the Sex-Specific Effects of Genes on Facial Attractiveness and Sexual Dimorphism
Mitchem DG; Purkey AM; Grebe NM; Carey G; Garver-Apgar CE; Bates TC; Arden R; Hewitt JK; Medland SE; Martin NG...
- Mitchem DG
- Purkey AM
- Grebe NM
- Carey G
- Garver-Apgar CE
- Bates TC
- Arden R
- Hewitt JK
- Medland SE
- Martin NG
Publication Date: 2014-05-01
Type: Journal Article
Estimating the Sex-Specific Effects of Genes on Facial Attractiveness and Sexual Dimorphism
Mitchem DG; Purkey AM; Grebe NM; Carey G; Garver-Apgar CE; Bates TC; Arden R; Hewitt JK; Medland SE; Martin NG...
- Mitchem DG
- Purkey AM
- Grebe NM
- Carey G
- Garver-Apgar CE
- Bates TC
- Arden R
- Hewitt JK
- Medland SE
- Martin NG
Publication Date: 2014-05-01
Type: Conference Proceeding
A Recessive Genetic Model and Runs of Homozygosity in Major Depressive Disorder
Publication Date: 2014-03-01
Type: Journal Article
Genetic Factors That Increase Male Facial Masculinity Decrease Facial Attractiveness of Female Relatives
Publication Date: 2014-02-01
Type: Journal Article
Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT)
Lencz T; Knowles E; Davies G; Guha S; Liewald DC; Starr JM; Djurovic S; Melle I; Sundet K; Christoforou A...
- Lencz T
- Knowles E
- Davies G
- Guha S
- Liewald DC
- Starr JM
- Djurovic S
- Melle I
- Sundet K
- Christoforou A
Publication Date: 2014-02-01
Type: Journal Article
Whole-Genome Pathway Analysis on 132,497 Individuals Identifies Novel Gene-Sets Associated with Body Mass Index
Publication Date: 2014-01-31
Type: Journal Article
Gene x Environment Interaction Studies Have Not Properly Controlled for Potential Confounders: The Problem and the (Simple) Solution
Publication Date: 2014-01-01
Type: Journal Article
Estimation of SNP Heritability from Dense Genotype Data
Publication Date: 2013-12-05
Type: Journal Article
Schizophrenia genetic variants are not associated with intelligence
van Scheltinga AFT; Bakker SC; van Haren NEM; Derks EM; Buizer-Voskamp JE; Cahn W; Ripke S; Ophoff RA; Kahn RS...
- van Scheltinga AFT
- Bakker SC
- van Haren NEM
- Derks EM
- Buizer-Voskamp JE
- Cahn W
- Ripke S
- Ophoff RA
- Kahn RS
Publication Date: 2013-12-01
Type: Journal Article
Behavior Genetics Association 43rd Annual Meeting Abstracts
Publication Date: 2013-11-01
Type: Journal Article
Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent
de Candia TR; Lee SH; Yang J; Browning BL; Gejman PV; Levinson DF; Mowry BJ; Hewitt JK; Goddard ME; O'Donovan MC...
- de Candia TR
- Lee SH
- Yang J
- Browning BL
- Gejman PV
- Levinson DF
- Mowry BJ
- Hewitt JK
- Goddard ME
- O'Donovan MC
Publication Date: 2013-09-05
Type: Journal Article
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Lee SH; Ripke S; Neale BM; Faraone SV; Purcell SM; Perlis RH; Mowry BJ; Thapar A; Goddard ME; Witte JS...
- Lee SH
- Ripke S
- Neale BM
- Faraone SV
- Purcell SM
- Perlis RH
- Mowry BJ
- Thapar A
- Goddard ME
- Witte JS
Publication Date: 2013-09-01
Type: Journal Article
The Nature and Nurture of High IQ: An Extended Sensitive Period for Intellectual Development
Brant AM; Munakata Y; Boomsma DI; DeFries JC; Haworth CMA; Keller MC; Martin NG; McGue M; Petrill SA; Plomin R...
- Brant AM
- Munakata Y
- Boomsma DI
- DeFries JC
- Haworth CMA
- Keller MC
- Martin NG
- McGue M
- Petrill SA
- Plomin R
Publication Date: 2013-08-01
Type: Journal Article
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
Smoller JW; Craddock N; Kendler K; Lee PH; Neale BM; Nurnberger JI; Ripke S; Santangelo S; Sullivan PF; Purcell S...
- Smoller JW
- Craddock N
- Kendler K
- Lee PH
- Neale BM
- Nurnberger JI
- Ripke S
- Santangelo S
- Sullivan PF
- Purcell S
Publication Date: 2013-04-20
Type: Journal Article
All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs
Schork AJ; Thompson WK; Pham P; Torkamani A; Roddey JC; Sullivan PF; Kelsoe JR; O'Donovan MC; Furberg H; Schork NJ...
- Schork AJ
- Thompson WK
- Pham P
- Torkamani A
- Roddey JC
- Sullivan PF
- Kelsoe JR
- O'Donovan MC
- Furberg H
- Schork NJ
Publication Date: 2013-04-01
Type: Journal Article
The Genetic Correlation between Height and IQ: Shared Genes or Assortative Mating?
Publication Date: 2013-04-01
Type: Journal Article
Genetic Schizophrenia Risk Variants Jointly Modulate Total Brain and White Matter Volume
van Scheltinga AFT; Bakker SC; van Haren NEM; Derks EM; Buizer-Voskamp JE; Boos HBM; Cahn W; Pol HEH; Ripke S; Ophoff RA...
- van Scheltinga AFT
- Bakker SC
- van Haren NEM
- Derks EM
- Buizer-Voskamp JE
- Boos HBM
- Cahn W
- Pol HEH
- Ripke S
- Ophoff RA
Publication Date: 2013-03-15
Type: Journal Article
Correction for Verweij et al. (2012)
Publication Date: 2013-03-01
Type: Journal Article
Improved Detection of Common Variants Associated with Schizophrenia by Leveraging Pleiotropy with Cardiovascular-Disease Risk Factors
Andreassen OA; Djurovic S; Thompson WK; Schork AJ; Kendler KS; O'Donovan MC; Rujescu D; Werge T; van de Bunt M; Morris A...
- Andreassen OA
- Djurovic S
- Thompson WK
- Schork AJ
- Kendler KS
- O'Donovan MC
- Rujescu D
- Werge T
- van de Bunt M
- Morris AP
Publication Date: 2013-02-07
Type: Journal Article
Maintenance of variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding (vol 66, pg 3238, 2012)
Verweij KJH; Yang J; Lahti J; Veijola J; Hintsanen M; Pulkki-Raback L; Heinonen K; Pouta A; Pesonen A-K; Widen E...
- Verweij KJH
- Yang J
- Lahti J
- Veijola J
- Hintsanen M
- Pulkki-Raback L
- Heinonen K
- Pouta A
- Pesonen A-K
- Widen E
Publication Date: 2013-01-01
Type: Journal Article
Awards Presented at the 41st Annual Meeting of the BEHAVIOR GENETICS ASSOCIATION
Publication Date: 2012-11-01
Type: Journal Article
Pages
Recruiting
The Keller lab is not currently recruiting new graduate students.
Contact Matt Keller directly about postdoctoral trainee positions.