
Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447
Research Interests:
Developing models to understand complex trait genetics. Using family-based GWAS datasets to estimate direct genetic effects and the environmental influences of parents on offspring. Modeling and simulating genetically informative designs that better enable us to understand the causes of human differences.
Active Grants:
- NIMH R01 MH130448 7/2022-6/2027 Causes and consequences of mental disorders: The environmental and genetic influences of parents on offspring. Role: Principal investigator
- NIMH 2R01 MH100141 2/2013-4/2023 Estimating the genetic and environmental architecture of psychiatric disorders. Role: Principal investigator
- NIMH R25 MH019918 2/2024-1/2029 Workshop on statistical genetic methods for human complex traits. Role: Principal investigator
- NIDA R01 DA054087 5/1/2022 – 4/30/2027 Understanding the links between parental and adolescent substance use: complementary natural experiments using the children of twins design. Role: Co-Principal investigator
- NIDA R01 DA046064 4/2018-1/2023 Brain and genetic predictors of individual differences in pain and placebo analgesia. Role: Co-investigator
- NIDA R01 DA044283 5/2019 – 2/2024 Deep sequencing, phenotyping, and imputation in large-scale biobanks: A novel and cost-effective framework to identify rare mutations associated with addiction. Role: Principal investigator of subcontract
- NIDA R01 DA053693 4/2024 – 3/2028 Adult Progression of Adolescent Onset Substance Use Disorder in a High Risk Sample. Role: Co-investigator
Additional Resources:
Current Lab






Former Trainees
Spencer Moore
Masters student
2020-2022
Jared Balbona
Doctoral student
2018-2022
Richard Border
Doctoral student
2014-2019
Emma Johnson
Doctoral student
2012-2017
Teresa de Candia
Doctoral student
2011-2015
Matthew Simonson
Doctoral student
2008-2013
Dan Howrigan
Doctoral student
2008-2012
Laramie Duncan
Doctoral student
2008-2010
Subrata Paul
Postdoctoral trainee
2020-2021
Meng Huang
Postdoctoral trainee
2020-2021
Rasool Tahmasbi
Postdoctoral trainee
2015-2018
Luke Evans
Postdoctoral trainee
2015-2018
Doug Bjelland
Postdoctoral trainee
2013-2016
Christine Garver-Apgar
Postdoctoral trainee
2008-2011
Whole-Genome Pathway Analysis on 132,497 Individuals Identifies Novel Gene-Sets Associated with Body Mass Index
Publication Date: 2014-01-31
Type: Journal Article
Gene x Environment Interaction Studies Have Not Properly Controlled for Potential Confounders: The Problem and the (Simple) Solution
Publication Date: 2014-01-01
Type: Journal Article
Estimation of SNP Heritability from Dense Genotype Data
Publication Date: 2013-12-05
Type: Journal Article
Schizophrenia genetic variants are not associated with intelligence
van Scheltinga AFT; Bakker SC; van Haren NEM; Derks EM; Buizer-Voskamp JE; Cahn W; Ripke S; Ophoff RA; Kahn RS...
- van Scheltinga AFT
- Bakker SC
- van Haren NEM
- Derks EM
- Buizer-Voskamp JE
- Cahn W
- Ripke S
- Ophoff RA
- Kahn RS
Publication Date: 2013-12-01
Type: Journal Article
Behavior Genetics Association 43rd Annual Meeting Abstracts
Publication Date: 2013-11-01
Type: Journal Article
Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent
de Candia TR; Lee SH; Yang J; Browning BL; Gejman PV; Levinson DF; Mowry BJ; Hewitt JK; Goddard ME; O'Donovan MC...
- de Candia TR
- Lee SH
- Yang J
- Browning BL
- Gejman PV
- Levinson DF
- Mowry BJ
- Hewitt JK
- Goddard ME
- O'Donovan MC
Publication Date: 2013-09-05
Type: Journal Article
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Lee SH; Ripke S; Neale BM; Faraone SV; Purcell SM; Perlis RH; Mowry BJ; Thapar A; Goddard ME; Witte JS...
- Lee SH
- Ripke S
- Neale BM
- Faraone SV
- Purcell SM
- Perlis RH
- Mowry BJ
- Thapar A
- Goddard ME
- Witte JS
Publication Date: 2013-09-01
Type: Journal Article
The Nature and Nurture of High IQ: An Extended Sensitive Period for Intellectual Development
Brant AM; Munakata Y; Boomsma DI; DeFries JC; Haworth CMA; Keller MC; Martin NG; McGue M; Petrill SA; Plomin R...
- Brant AM
- Munakata Y
- Boomsma DI
- DeFries JC
- Haworth CMA
- Keller MC
- Martin NG
- McGue M
- Petrill SA
- Plomin R
Publication Date: 2013-08-01
Type: Journal Article
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
Smoller JW; Craddock N; Kendler K; Lee PH; Neale BM; Nurnberger JI; Ripke S; Santangelo S; Sullivan PF; Purcell S...
- Smoller JW
- Craddock N
- Kendler K
- Lee PH
- Neale BM
- Nurnberger JI
- Ripke S
- Santangelo S
- Sullivan PF
- Purcell S
Publication Date: 2013-04-20
Type: Journal Article
All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPs
Schork AJ; Thompson WK; Pham P; Torkamani A; Roddey JC; Sullivan PF; Kelsoe JR; O'Donovan MC; Furberg H; Schork NJ...
- Schork AJ
- Thompson WK
- Pham P
- Torkamani A
- Roddey JC
- Sullivan PF
- Kelsoe JR
- O'Donovan MC
- Furberg H
- Schork NJ
Publication Date: 2013-04-01
Type: Journal Article
The Genetic Correlation between Height and IQ: Shared Genes or Assortative Mating?
Publication Date: 2013-04-01
Type: Journal Article
Genetic Schizophrenia Risk Variants Jointly Modulate Total Brain and White Matter Volume
van Scheltinga AFT; Bakker SC; van Haren NEM; Derks EM; Buizer-Voskamp JE; Boos HBM; Cahn W; Pol HEH; Ripke S; Ophoff RA...
- van Scheltinga AFT
- Bakker SC
- van Haren NEM
- Derks EM
- Buizer-Voskamp JE
- Boos HBM
- Cahn W
- Pol HEH
- Ripke S
- Ophoff RA
Publication Date: 2013-03-15
Type: Journal Article
Correction for Verweij et al. (2012)
Publication Date: 2013-03-01
Type: Journal Article
Improved Detection of Common Variants Associated with Schizophrenia by Leveraging Pleiotropy with Cardiovascular-Disease Risk Factors
Andreassen OA; Djurovic S; Thompson WK; Schork AJ; Kendler KS; O'Donovan MC; Rujescu D; Werge T; van de Bunt M; Morris A...
- Andreassen OA
- Djurovic S
- Thompson WK
- Schork AJ
- Kendler KS
- O'Donovan MC
- Rujescu D
- Werge T
- van de Bunt M
- Morris AP
Publication Date: 2013-02-07
Type: Journal Article
Maintenance of variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding (vol 66, pg 3238, 2012)
Verweij KJH; Yang J; Lahti J; Veijola J; Hintsanen M; Pulkki-Raback L; Heinonen K; Pouta A; Pesonen A-K; Widen E...
- Verweij KJH
- Yang J
- Lahti J
- Veijola J
- Hintsanen M
- Pulkki-Raback L
- Heinonen K
- Pouta A
- Pesonen A-K
- Widen E
Type: Journal Article
Awards Presented at the 41st Annual Meeting of the BEHAVIOR GENETICS ASSOCIATION
Publication Date: 2012-11-01
Type: Journal Article
MAINTENANCE OF GENETIC VARIATION IN HUMAN PERSONALITY: TESTING EVOLUTIONARY MODELS BY ESTIMATING HERITABILITY DUE TO COMMON CAUSAL VARIANTS AND INVESTIGATING THE EFFECT OF DISTANT INBREEDING
Verweij KJH; Yang J; Lahti J; Veijola J; Hintsanen M; Pulkki-Raback L; Heinonen K; Pouta A; Pesonen A-K; Widen E...
- Verweij KJH
- Yang J
- Lahti J
- Veijola J
- Hintsanen M
- Pulkki-Raback L
- Heinonen K
- Pouta A
- Pesonen A-K
- Widen E
Publication Date: 2012-10-01
Type: Journal Article
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs (vol 44, pg 247, 2012)
Publication Date: 2012-07-01
Type: Journal Article
Runs of Homozygosity Implicate Autozygosity as a Schizophrenia Risk Factor
Keller MC; Simonson MA; Ripke S; Neale BM; Gejman PV; Howrigan DP; Lee SH; Lencz T; Levinson DF; Sullivan PF...
- Keller MC
- Simonson MA
- Ripke S
- Neale BM
- Gejman PV
- Howrigan DP
- Lee SH
- Lencz T
- Levinson DF
- Sullivan PF
Publication Date: 2012-04-01
Type: Journal Article
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
Publication Date: 2012-03-01
Type: Journal Article
Response to Pluess and Belsky Letter
Publication Date: 2012-02-01
Type: Journal Article
Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk
Publication Date: 2011-10-26
Type: Journal Article
Genome-wide association study identifies five new schizophrenia loci
Ripke S; Sanders AR; Kendler KS; Levinson DF; Sklar P; Holmans PA; Lin D-Y; Duan J; Ophoff RA; Andreassen OA...
- Ripke S
- Sanders AR
- Kendler KS
- Levinson DF
- Sklar P
- Holmans PA
- Lin D-Y
- Duan J
- Ophoff RA
- Andreassen OA
Publication Date: 2011-10-01
Type: Journal Article
A Critical Review of the First 10 Years of Candidate Gene-by-Environment Interaction Research in Psychiatry
Publication Date: 2011-10-01
Type: Journal Article
Detecting autozygosity through runs of homozygosity: A comparison of three autozygosity detection algorithms
Publication Date: 2011-09-23
Type: Journal Article
Pages
Recruiting
The Keller lab is recruiting new graduate students.
Contact Matt Keller directly about postdoctoral trainee positions.