Institute for Behavioral Genetics
University of Colorado Boulder
447 UCB
Boulder, CO 80309-0447
Research Interests:
The use of genetic strategies to identify the underlying biological bases for the behavioral and physiological actions of drugs of abuse with special emphasis on nicotine.
Active Grants:
- NIDA U01DA043802 (Stitzel, JA, Radcliffe, RA) 4/1/18-12/31/22. Genetic modifiers of Chrna5 deletion in mice: role in nicotine behaviors modulated by the medial habenula-IPN pathway. Role: PI
- NIDA R01DA044283 (Vrieze, S). Deep sequencing, phenotyping, and imputation in large-scale biobanks: a novel and cost-effective framework to identify rare mutations associated with addiction. Role: Co-investigator
-
AB Nexus Grant (Stitzel, Patel MPI). Multi-generation impact of developmental nicotine exposure on mitochondrial function. Role: Lead PI
Additional Resources:
Molecular Neurogenetics Laboratory
Current lab
Former Trainees
Jennifer Wilking
Doctoral student
2005-2009
Sheila Maier
Masters student
2006-2008
Tristan McClure-Begley
Doctoral student
2008-2010
Janessa Jacobs
Masters student
2008-2010
William Horton
Doctoral student
2009-2013
Hunter Mathews
Doctoral student
2014-2020
Jordan Buck
Doctoral student
2016-2020
Amanda Alvarado
Masters student
2017-2019
Xiao Li
Postdoctoral trainee
2002-2003
Sharon Mexal
Postdoctoral trainee
2005-2007
Tom Precht
Postdoctoral trainee
2008-2010
Anne Tammamaki
Postdoctoral trainee
2009-2012
Cristian Zambrano
Postdoctoral trainee
2009-2012, 2015-2017
Andre Zalud
Postdoctoral trainee
2011-2014
Rebecca Helfand
Postdoctoral trainee
2011-2014
Peter Dobelis
Postdoctoral trainee
2015-2017
Heidi O'Neill
Postdoctoral trainee
2015-2019
Recent advances in gene manipulation and nicotinic acetylcholine receptor biology
Publication Date: 2011-10-15
Type: Journal Article
CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences
Publication Date: 2011-03-01
Type: Journal Article
Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence
Culverhouse RC; Saccone NL; Stitzel JA; Wang JC; Steinbach JH; Goate AM; Schwantes-An T-H; Grucza RA; Stevens VL; Bierut...
- Culverhouse RC
- Saccone NL
- Stitzel JA
- Wang JC
- Steinbach JH
- Goate AM
- Schwantes-An T-H
- Grucza RA
- Stevens VL
- Bierut LJ
Publication Date: 2011-02-01
Type: Journal Article
Nicotinic Receptors in Brain Diseases
Publication Date: 2011-01-01
Type: Chapter
Response to "Dizziness Genes"
Publication Date: 2010-09-01
Type: Journal Article
Activation and Inhibition of Mouse Muscle and Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes
Publication Date: 2010-05-01
Type: Journal Article
Association of CHRN Genes With "Dizziness" to Tobacco
Publication Date: 2010-03-01
Type: Journal Article
Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity
Publication Date: 2010-02-01
Type: Journal Article
Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5
Publication Date: 2009-08-15
Type: Journal Article
Multiple Distinct Risk Loci for Nicotine Dependence Identified by Dense Coverage of the Complete Family of Nicotinic Receptor Subunit (CHRN) Genes
Saccone NL; Saccone SF; Hinrichs AL; Stitzel JA; Duan W; Pergadia ML; Agrawal A; Breslau N; Grucza RA; Hatsukami D...
- Saccone NL
- Saccone SF
- Hinrichs AL
- Stitzel JA
- Duan W
- Pergadia ML
- Agrawal A
- Breslau N
- Grucza RA
- Hatsukami D
Publication Date: 2009-06-05
Type: Journal Article
Acetylcholine-Stimulated [3H] GABA Release from Mouse Brain Synaptosomes is Modulated by α4β2 and α4α5β2 Nicotinic Receptor Subtypes
Publication Date: 2009-04-01
Type: Journal Article
Chrna7 genotype is linked with alpha7 nicotinic receptor expression but not alpha7 RNA levels
Publication Date: 2009-03-31
Type: Journal Article
A Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence
Grucza RA; Wang JC; Stitzel JA; Hinrichs AL; Saccone SF; Saccone NL; Bucholz KK; Cloninger CR; Neuman RJ; Budde JP...
- Grucza RA
- Wang JC
- Stitzel JA
- Hinrichs AL
- Saccone SF
- Saccone NL
- Bucholz KK
- Cloninger CR
- Neuman RJ
- Budde JP
Publication Date: 2008-12-01
Type: Journal Article
Variants in nicotinic receptors and risk for nicotine dependence
Bierut LJ; Stitzel JA; Wang JC; Hinrichs AL; Grucza RA; Xuei X; Saccone NL; Saccone SF; Bertelsen S; Fox L...
- Bierut LJ
- Stitzel JA
- Wang JC
- Hinrichs AL
- Grucza RA
- Xuei X
- Saccone NL
- Saccone SF
- Bertelsen S
- Fox L
Publication Date: 2008-09-01
Type: Journal Article
The incentive salience of alcohol - Translating the effects of genetic variant in CNR1
Publication Date: 2008-07-01
Type: Journal Article
Naturally occurring genetic variability in the nicotinic acetylcholine receptor alpha4 and alpha7 subunit genes and phenotypic diversity in humans and mice
Publication Date: 2008-01-01
Type: Journal Article
Chlorisondamine inhibits the nicotine-induced stimulation of c-fos in the pigeon brain for up to 2 weeks
Publication Date: 2007-09-01
Type: Journal Article
CHRNA4 and tobacco dependence - From gene regulation to treatment outcome
Hutchison KE; Allen DL; Filbey FM; Jepson C; Lerman C; Benowitz NL; Stitzel J; Bryan A; McGeary J; Haughey HM...
- Hutchison KE
- Allen DL
- Filbey FM
- Jepson C
- Lerman C
- Benowitz NL
- Stitzel J
- Bryan A
- McGeary J
- Haughey HM
Publication Date: 2007-09-01
Type: Journal Article
Chromosomal loci that influence oral nicotine consumption in C57BL/6J x C3H/HeJ F-2 intercross mice
Publication Date: 2007-07-01
Type: Journal Article
alpha-7 Nicotinic receptor gene promoter polymorphisms in inbred mice affect expression in a cell type-specific fashion
Publication Date: 2007-05-04
Type: Journal Article
Development of hippocampal alpha 7 nicotinic receptors C3H and DBA/2 congenic mice
Publication Date: 2006-11-29
Type: Journal Article
Genetic correlation between the free-choice oral consumption of nicotine and alcohol in C57BL/6J x C3H/HeJ F2 intercross mice
Publication Date: 2005-02-10
Type: Journal Article
Modulation of nicotine but not ethanol preference by the mouse Chrna4 A529T polymorphism
Publication Date: 2005-02-01
Type: Journal Article
alpha-conotoxin BuIA, a novel peptide from Conus bullatus, distinguishes among neuronal nicotinic acetylcholine receptors
Publication Date: 2005-01-07
Type: Journal Article
Functional characterization of mouse α4β2 nicotinic acetylcholine receptors stably expressed in HEK293T cells
Publication Date: 2004-12-01
Type: Journal Article
Pages
Recruiting
Dr. Stitzel is recruiting new students for a fall 2025 start date. Applications are typically due mid November; for exact dates please check the Department of Integrative Physiology website, if you intend to work with Dr. Stitzel. Additional information is available on IBG's Prospective Students page.
The Stitzel lab is not currently recruiting postdocs.