We are interested in stem cell biology and cell fate change with an emphasis on epigenetic and post-transcriptional regulation
Telomerase, an RNP enzyme critical for chromosome end-replication, provides the subject for much of our research.
Molecular evolution of enzymes and metabolic pathways; mechanistic enzymology; biodegradation of xenobiotic pollutants; bioinformatics.
Mechanistic basis for individual differences in behavior and how these impact likelihood to develop mental illness.
Understanding transcriptional regulation: how does it work, evolve, and respond to perturbations?
Genetic and molecular analysis of cell signaling, gene expression and metabolic events in regulating cellular and developmental events.
Cryo-electron microscopy and 3-D reconstruction of large macromolecular assemblies and cellular structures, whenever possible in vivo.
Embryonic patterning, gene regulatory networks, effective teacher education, coherent biology course and curricular design and delivery, improving student learning.
Biochemistry, molecular engineering, optics, microfluidics, image processing, membrane voltage sensing, electrophysiology, bacteria, cardiomyocytes, neurons.
Explore the relationships between genes, brain activities and risk behaviors, including those associated with increased HIV risk.
The Niswander lab investigates novel mouse models of embryonic development with the overarching goal of providing insights into fundamental developmental processes, major human birth defects and potential clinical therapies.
Signaling networks that regulate cell growth, communication and migration in multicellular organisms, and to better understand how these networks become disregulated and drive cancer.
Stem cell biology; regeneration; skeletal muscle regeneration and aging; skeletal muscle stem cells and gene therapy; growth factors and signal transduction; mouse molecular genetics; muscular dystrophies and neuromuscular diseases.
We study the biogenesis of a molecular machine known as the proteasome, a major protease in eukaryotes.
We specialize in developing and applying high precision measurements using optical traps and atomic force microscopes to answer interesting questions.
The Sawyer lab studies viral immunity, viral evolution, and the transmission of viruses from animals to man.
The overarching goal of my group is to uncover the regulatory principles of vesicle-mediated cargo transport.
Our research is focused on molecular and supramolecular structures that facilitate communication between neurons at the chemical synapse and how such structures are perturbed in neurological disease.
Our goal is to understand how cells, tissues and organisms survive exposure to high energy radiation such as X-rays.
At present, we are investigating why these mitochondria normally remain hypo-polarized and what effects this may have on certain elements of the oolemma found to be essential for sperm docking and penetration.
Dr. Xue's research interests lie in studying the mechanisms of programmed cell death (or apoptosis), phospholipid asymmetry in biological membranes, mitochondrial inheritance, and radiation-induced bystander effects, as well as various human diseases associated with abnormalities in these fundamental biological processes.