Research Labs

Arnoult

The Arnoult lab focuses on genome stability, DNA repair and telomere biology.

DNA methylation and hydroxymethylation dynamics at nucleotide resolution using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs).

Brumbaugh

We are interested in stem cell biology and cell fate change with an emphasis on epigenetic and post-transcriptional regulation

Cech

Telomerase, an RNP enzyme critical for chromosome end-replication, provides the subject for much of our research.

Viruses related to MER41 have independently invaded other mammalian genomes.

Chuong

The Chuong lab is interested in the evolution of gene regulation in adaptation and disease.

Tetrachlorohydroquinone dehalogenase catalyzes the reaction shown at right during the degradation of pentachlorophenol by Sphingobium chlorophenolicum, It also catalyzes the double bond isomerization shown at left at the same active site, suggesting that it arose from an enzyme such as maleylacetoacetate isomerase or maleylpyruvate isomerase, which are involved in degradation of tyrosine and benzoate, respectively.

Copley

Molecular evolution of enzymes and metabolic pathways; mechanistic enzymology; biodegradation of xenobiotic pollutants; bioinformatics.

Detweiler

Salmonella host-pathogen interactions
that contribute to persistent infection.

Donaldson

Mechanistic basis for individual differences in behavior and how these impact likelihood to develop mental illness.

Genome-wide analysis of Drosophila upon MSL treatment reveals new insights into transcriptional profiles.

Dowell

Understanding transcriptional regulation: how does it work, evolve, and respond to perturbations?

Garcea

Structure and assembly of small DNA viruses, with emphasis on polyoma and papillomaviruses.

Food-Seeking Ability Is Compromised in mmBCFA-Deficient L1 Larvae

Han

Genetic and molecular analysis of cell signaling, gene expression and metabolic events in regulating cellular and developmental events.

Electron micrograph of intermediate filaments.

Hoenger

Cryo-electron microscopy and 3-D reconstruction of large macromolecular assemblies and cellular structures, whenever possible in vivo.

The striatum lacks apparent BDNF express.

Jones

Molecular genetics of mouse neural development.

Klymkowsky

Embryonic patterning, gene regulatory networks, effective teacher education, coherent biology course and curricular design and delivery, improving student learning.

Knight

Interactive teaching methods to increase conceptual understanding.

Kralj

Biochemistry, molecular engineering, optics, microfluidics, image processing, membrane voltage sensing, electrophysiology, bacteria, cardiomyocytes, neurons.

Krauter

Explore the relationships between genes, brain activities and risk behaviors, including those associated with increased HIV risk.

Leinwand

Myosin mutations and their effect on the heart, skeleton, and overall health.

GCN5 acetyltransferase activity is required for RA signaling in the developing forebrain.

The Niswander lab investigates novel mouse models of embryonic development with the overarching goal of providing insights into fundamental developmental processes, major human birth defects and potential clinical therapies.

Mutation of Vps20 MIMa6 rescues ILV budding defects in bro1D cells.

Odorizzi

Cell biology and genetics of membrane trafficking and protein degradation.

Contour plots showing the density of spectra when plotted by neutral loss of water or ammonia.

Old

Signaling networks that regulate cell growth, communication and migration in multicellular organisms, and to better understand how these networks become disregulated and drive cancer.

Satellite cells enable muscle regeneration.

Olwin

Stem cell biology; regeneration; skeletal muscle regeneration and aging; skeletal muscle stem cells and gene therapy; growth factors and signal transduction; mouse molecular genetics; muscular dystrophies and neuromuscular diseases.

DNA damage foci form rapidly after SINE treatment.

Orth

We study cancer therapies at the molecular and cellular level.

Nucleotide-dependent rearrangement of Rpn6.

Park

We study the biogenesis of a molecular machine known as the proteasome, a major protease in eukaryotes.

Perkins

We specialize in developing and applying high precision measurements using optical traps and atomic force microscopes to answer interesting questions.

Amino acid sequences of a portion of CCR5.

Sawyer

The Sawyer lab studies viral immunity, viral evolution, and the transmission of viruses from animals to man.

Shen

The overarching goal of my group is to uncover the regulatory principles of vesicle-mediated cargo transport.

RT-PCR analysis reveals differentially expressed transcripts.

Singh

Dr. Singh's laboratory studies post-transcriptional gene regulation.

Stowell

Our research is focused on molecular and supramolecular structures that facilitate communication between neurons at the chemical synapse and how such structures are perturbed in neurological disease.

The extra growths in regenerated disks are ectopic wing disks.

Su

Our goal is to understand how cells, tissues and organisms survive exposure to high energy radiation such as X-rays.

Van Blerkom

At present, we are investigating why these mitochondria normally remain hypo-polarized and what effects this may have on certain elements of the oolemma found to be essential for sperm docking and penetration.

Voeltz

Our lab is studying how proteins generate the shape of the endoplasmic reticulum (ER).

Systematic presentation of an intra-animal model to assay RIBE.

Xue

Dr. Xue's research interests lie in studying the mechanisms of programmed cell death (or apoptosis), phospholipid asymmetry in biological membranes, mitochondrial inheritance, and radiation-induced bystander effects, as well as various human diseases associated with abnormalities in these fundamental biological processes.

Dynamic expression of Foxc1 in the bulge.

Yi

We are interested in the elucidation of gene expression regulatory networks controlled by transcription factors and miRNAs among others in mammalian skin development, stem cells and cancer.

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Research Labs