Selected Publications
- Stern, JL, Theodorescu, D, Vogelstein, B, Papadopoulos, N, Cech, TR. Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers. Genes Dev. 29: 2219-2224. (2015).
- Schmidt, J. C., Zaug, A. J. and Cech, T. R. Live cell imaging reveals dynamic interactions that drive telomerase recruitment to telomeres. Cell 166: 1188-1197 (2016).
- Wang, X., Long, Y., Paucek, R. D., Gooding, A. R., Lee, T., Burdorf, R. M., & Cech, T.R. Regulation of histone methylation by authmethylation of PRC2. Genes Dev, 33, 1416-1427 (2019).
- Lim, C. J., Barbour, A. T., Zaug, A. J., Goodrich, K. J., McKay, A. E., Wuttke, D. S., & Cech, T. R. The structure of human CST reveals a decameric assembly bound to telomeric DNA. Science, 368, 1081-1085 (2020).
- Long, Y., Hwang, T., Gooding, A. R., Goodrich, K. J., Rinn, J. L., & Cech, T. R. RNA is essential for PRC2 chromatin occupancy and function in human pluripotent stem cells. Nat Genet, 10.1038/s41588-020-0662-x, Advance online publication (2020).
- Youmans DT, Gooding AR, Dowell RD, Cech TR. Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells. Mol Cell, 81, 488-501 (2021).
