Emeritus

My group does deep proteomic studies on blood from people with Down syndrome in order to discover what signaling protein alterations are responsible for the many phenotypes as well as their high level of variability.

The nerve cells in the brain are capable of changing their connections as a function of experience, a phenomenon called plasticity. Plasticity is especially strong in newborns and young animals. I studied this plasticity in adults.

The Garcea laboratory studies the structure and assembly of small DNA viruses, with emphasis on polyoma and papillomaviruses.

My laboratory studied the functions of neurotrophic factors in development and their relevance to neurodegenerative disease using a blend of transgenic mouse technology and anatomical, cell biological, and molecular techniques.

Chromosome replication in Escherichia coli and its interactions with the cell cycle.

We study the mechanisms of mitotic chromosome movement and microtubule dynamics, using both structural and biophysical approaches.

Winner of the 2017 Massry Prize, Distinguished Professor Emeritus Norman Pace studied the microbiome.

Our research focusses on mitochondria, cellular energetics, reactive oxygen species and their roles in physiology, disease, and aging.

Curriculum Vitae

RNA structure and function; RNA catalysis; mechanisms of translation; origins of translation.