SEPT3 (SEPTIN3)

Nicotine Gene Report Key

N = No/insufficient data. Will be updated as they become available.  

- = Data have been collected, but there is weak support for the gene. Included in network 

+ = Moderate support for the gene. 

++ = Strong support for the gene.

Default thresholds (-,+,++) differ by data type and are defined once you click on the link for more detail. Thresholds for each item and weighting of each item for overall priority score can be adjusted by the user.

SNP level association from available GWAS data

Gene level association based on results from available GWAS data

Mouse Studies

Within a QTL for a nicotine phenotype (P2 and other studies) 
Acute sensitivity (+)Reward (-)Consumption (+)Withdrawal (N)Other (-)
               Within a QTL for other addiction-related phenotypes                    
Behavioral (++)                                             Other drug of abuse (-)   

 

Mouse Studies Regulatory EvidenceKey
TWAS (DIPFC)+
TWAS (NACC)-
Included in network N
mRNA differences ++
eQTL +
Methylation differences-
Implicated miRNA target N
Mouse Models       Key
One or more model is available and lives+
Evidence for nicotine phenotype ++
Evidence for drug-related behavioral phenotype (e.g. anxiety)-
Evidence for other phenotype D (e.g. metabolism, heart rate)N

Other Characteristics

  • Target Drug (N) 
  • Conservation of DNA/mRNA/exon use between humans/mice (-)
  • Human/mouse brain expression pattern similarity (+)
  • Human/mouse cell-type specific expression (++)
  • Gene similarity clustering evidence (N)