N1. Estimating Changes in Genetic Effects across Age and Time

Presenter

Dorret Boomsma

First Presented

June 2021 Virtual Workshop

Content

“Genes Over Time” can refer to the changes in genetic variance and heritability as we compare these across generations and time; it may also refer to differential gene expression as a function of age, i.e. genotype by age interaction.  To establish if the same genes are expressed and whether their relative importance changes during the lifespan, multiple designs can be applied, including longitudinal studies with repeated measures on the same individuals (e.g. in the classical design) or multi-generation data (e.g. parent-twin studies).