Published: April 16, 2015

Dynamics of sleep-wake regulation

Cecilia Diniz Behn

Department of Applied Math & StatisticsColorado School of Mines

Date and time: 

Thursday, April 16, 2015 - 2:00pm


ECCR 257


Sleep and wake states are regulated by the coordinated activity of neuronal populations in the brainstem and hypothalamus.  Synaptic interactions among these populations define sleep-wake regulatory networks; however, the structure and dynamics of these networks, particularly with respect to the regulation of rapid eye movement (REM) sleep, are not well understood.  We have developed a mathematical modeling framework that is uniquely suited for investigating the dynamics of sleep-wake regulation.  I will discuss our analysis of network dynamics and the interplay between deterministic and stochastic model properties in the production of physiological sleep-wake behavior.