The minimum requirements for Honors are a 3.3 overall GPA, a successful defense, and a senior honors research project.
In the video above from 2013, Dr. David Sherwood, the Undergraduate Coordinator at the time, explains the Honors program for Integrative Physiology undergraduates. The requirements for the two types of Honors (Departmental and General) are described. Three levels of Honors can be achieved, and these depend on GPA as well as the quality of the written thesis and oral defense. Student questions are answered as well.
For more information, see the Arts and Sciences Honors Program website, or contact one of the IPHY Honors Council Representatives, Alena Grabowski and Mark Opp. More detail about what's involved in an Honors project, including formatting requirements and typical deadlines, is provided in the Student Guide for Honors.