Loren Hough

I currently study intrinsically disordered proteins using solution NMR. Proteins containing disordered domains perform many important cellular functions. The aggregations of some members of this family of proteins are implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. My lab currently has two main projects: (1) to dissect the role of tubulin's C-terminal tail in microtubule structure and functions, and (2) to better understand selective transport through the nuclear pore complex. We use microscopy, nuclear magnetic resonance and other biophysical techniques complemented with modeling to approach these systems. This work includes using in cell NMR, a technique to study the structure and dynamics of proteins within living cells.