Telomeres

The unexpected complexities of TERT, a key cancer driver

Sept. 11, 2019

Telomerase reverse transcriptase (TERT), an enzyme associated with nearly all malignant human cancers, is even more diverse and unconventional than previously realized, new University of Colorado Boulder research finds. Telomeres, the protective ends of chromosomes, help to maintain genomic stability. In most normal adult human cells, the telomeres eventually shorten...

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Nobel Laureate, Tom Cech, Ph.D., suggests new way to target third most common oncogene, TERT

Sept. 10, 2019

Healthy cells have a built-in self-destruct mechanism: Strands of DNA called "telomeres" act as protective caps on the ends of your chromosomes. Each time a cell replicates, telomeres get a little shorter. Think of it like filing your nails with an Emory board - after enough filing, you hit your...

Illustration: National Institutes of Health

A key ‘kill switch’ in a gene-regulating protein group

Sept. 9, 2019

CU Boulder and Howard Hughes Medical Institute (HHMI) biochemists have revealed a key regulatory process in a gene-suppressing protein group that could hold future applications for drug discovery and clinical treatment of diseases, including cancer. The new research, recently published in the journal Genes & Development , centered on a...

Tom Cech leads RNA splicing dance As part of biochemistry class

Faculty in Focus: Tom Cech looks back on Nobel Prize in chemistry

Dec. 31, 2018

It’s been 30 years since CU Boulder Distinguished Professor Tom Cech received the 1989 Nobel Prize in chemistry for his findings that RNA in living cells is not only a molecule that encodes information but can also function as a catalyst. His discovery laid the foundation for advances in molecular...

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Video: Nobel laureate Tom Cech still loves teaching

Oct. 15, 2018

CU Boulder's Tom Cech won the Nobel Prize for Chemistry in 1989, but he firmly believes his place is still in the classroom teaching undergraduates. Here, he discusses how teaching adds meaning to his life and how he still works to become a better teacher.

Daniel Youmans and Tom Cech

Researchers peer inside cells to spy on cancer's on-off switch

June 13, 2018

Medical student Daniel Youmans (left) and Tom Cech (right), director of the BioFrontiers Institute, look over an image from a high-powered microscope (Credit: Glenn Asakawa/CU Boulder) Forty years after researchers first discovered it in fruit flies, a once-obscure cluster of proteins called PRC2 has become a key target for new...

RNA splicing dance

Tom Cech leads RNA splicing dance

April 20, 2018

As part of BioFrontiers Institute Professor John Rinn’s biochemistry class, this week graduate students performed an RNA splicing interpretive dance on the west lawn of the Jennie Smoly Caruthers Biotech Building. CU Nobel Laureate and BioFrontiers Director Tom Cech (in the tie-dye T-shirt) played the starring role of the catalytic...

Participants of BizWest's CEO Roundtable on Life Sciences in Boulder are, from left, Misha Plam, Ron Squarer, David Kerr, William Marshall, Chris Shapard, Jennifer Jones, Tin Tin Su, Pawel Fludzinski, Amy Beckley, Tom Cech, Becky Potts, Kyle Lefkoff, Tom Hertzberg, Jonathan Vaught, Marvin Caruthers, Not pictured: Brynmor Reese. BizWest/Jensen Werley.

Boulder’s bioscience industry growing to critical mass

April 18, 2018

After years of companies being sold off or growing and relocating, Boulder’s life-sciences sector is showing signs of reaching critical mass. Companies such as Clovis Oncology Inc. (Nasdaq: CLVS), SomaLogic Inc., Array Biopharma Inc. (Nasdaq: ARRY) and miRagen Therapeutics Inc. (Nasdaq: MGEN) are showing that homegrown businesses can continue to...

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Nobel Laureate gives 2017 Herchel Smith Lecture

Oct. 9, 2017

Nobel Laureate Professor Tom Cech came to the Department of Chemistry on 16th October, to give the 2017 Herchel Smith Lecture: 'Shedding some Light on the Dark Matter of the Genomic Universe.' Professor Cech is Distinguished Professor at the University of Colorado Boulder, Director of the University of Colorado BioFrontiers...

Distinguished Professor Tom Cech. Photo: Glenn Asakawa / University of Colorado Boulder.

Nobel laureate Tom Cech wins 2017 Hazel Barnes Prize

March 24, 2017

University of Colorado Boulder Distinguished Professor Tom Cech, Colorado’s first Nobel Prize winner, has been named the 2017 Hazel Barnes Prize winner – the most distinguished award a faculty member can receive from the university. Cech, the director of the BioFrontiers Institute , shared the 1989 Nobel Prize in Chemistry...

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