Therapies

Mary Allen holds up a valentine sent to her from a childhood friend. It sits in her cubicle where she is hard at work tearing apart genomic data looking for patterns. This friend, who has Down syndrome, is part of the reason that Allen, a postdoctoral researcher in Robin Dowell’s...

A major collaboration of Colorado institutions uses new technology to show, after more than 30 years and 50,000 papers on the subject, the direct targets of the gene p53, the most potent “tumor suppressor” gene. The finding is a strong step toward affecting the disease trajectories of nearly all cancer...

The motor protein, myosin, has fascinated BioFrontiers Chief Scientific Officer Leslie Leinwand for more than 25 years. This protein is responsible for making muscles contract in the body, but Leinwand, a professor in molecular, cellular and developmental biology, is interested in its function in one important muscle: the heart. Myosin...

BioFrontiers scientist tackles a childhood disease of the heart BioFrontiers Chief Scientific Officer Leslie Leinwand, has been studying the motor protein, myosin, for 25 years. This important protein is responsible for making muscles contract, including one vital muscle: your heart. Myosin drives heart muscle contraction, and when this protein is...

CU professor co-founds new company to develop genetic heart disease treatment A new biomedical company involving the University of Colorado Boulder, Stanford University and the Harvard Medical School has been launched with $38 million in financing from Third Rock Ventures LLC headquartered in Boston and San Francisco to develop therapeutic...

In a new paper released today in Nature , BioFrontiers Institute scientists at the University of Colorado in Boulder, Tom Cech and Leslie Leinwand, detailed a new target for anti-cancer drug development that is sitting at the ends of our DNA. Researchers in the two scientists’ laboratories collaborated to find...

A University of Colorado Boulder-led research team has discovered that two protein receptors in the central nervous system team up to respond to morphine and cause unwanted neuroinflammation, a finding with implications for improving the efficacy of the widely used painkiller while decreasing its abuse potential. Scientists have known that...

On Science Friday: Leslie Leinwand discusses the Python Project On December 9, Biofrontiers Institute's Chief Scientific Officer Leslie Leinwand shared some scaly tales of her research with Burmese pythons on NPR's Science Friday. During the interview she shared the results of a paper she published in Science magazine earlier this...

Stopping cancer's knock on the door As a self-proclaimed “science nerd” in a Beijing high school, Hubert Yin considered biochemistry to be the ultimate in cool. It was the only science, he felt, that was capable of explaining what he thought was the most complex, most beautiful thing on earth–...

Pythons provide clues to human heart health A surprising new University of Colorado Boulder study shows that huge amounts of fatty acids circulating in the bloodstreams of feeding pythons promote healthy heart growth, results that may have implications for treating human heart disease. Biofrontiers Institute Chief Scientific Officer Leslie Leinwand...