The Nucleic Acids Chemistry and Biomedicine Symposium was organized to honor the scientific achievements of Distinguished Professor Marv Caruthers with a full day of talks by internationally renowned scientists. These talks inspired conversations regarding the power of nucleic acid chemistry in shaping both the past and future of scientific research, technology, and medicine. The Symposium took place on Saturday, September 17, 2022 in the Jennie Smoly Caruthers Biotechnology Building at the University of Colorado Boulder. A video of the talks that were approved for recording is available on the BioFrontiers YouTube channel.