Figure 3. (A) Circular hydrogels were bleached near their center with a nearly circular bleach spot.

Bound-State Diffusion due to Binding to Flexible Polymers in a Selective Biofilter.

Dec. 31, 2019

Selective biofilters are used by cells to control the transport of proteins, nucleic acids, and other macromolecules. Biological filters demonstrate both high specificity and rapid motion or high flux of proteins. In contrast, high flux comes at the expense of selectivity in many synthetic filters. Binding can lead to selective...

Schematics of the nuclear pore complex and model

Design principles of selective transport through biopolymer barriers

Oct. 23, 2019

In biological systems, polymeric materials block the movement of some macromolecules while allowing the selective passage of others. In some cases, binding enables selective transport, while in others the most inert particles appear to transit most rapidly. To study the general principles of filtering, we develop a model motivated by...

Loren Hough

Scientist develops a new way to look at a cellular shapeshifter

Oct. 21, 2016

Tubulin, a protein found in your cells, quietly lends itself to many life processes. It sorts itself into long chains, forming tubes that provide scaffolding for living cells. A versatile shapeshifter, tubulin can arrange itself into different structures during different types of cell behavior. Tubulin gained prominence for medical applications...