ffect of PBA-Ac concentration on the viscoelastic properties of boronate hydrogels.

Adaptable boronate ester hydrogels with tunable viscoelastic spectra to probe timescale dependent mechanotransduction

Oct. 31, 2019

Cells are capable of sensing the differences in elastic and viscous properties (i.e., the ‘viscoelasticity’) of their tissue microenvironment and responding accordingly by changing their transcriptional activity and modifying their behaviors. When designing viscoelastic materials to mimic the mechanical properties of native tissue niches, it is important to consider the...

 hMSC retraction in response to substrate viscoelasticity.

Photo-induced viscoelasticity in cytocompatible hydrogel substrates

Oct. 31, 2019

Human mesenchymal stem cells (hMSCs) sense and respond to the bulk elastic and viscoelastic properties of their microenvironment, as well as the spatial distribution of these mechanical signals. Hydrogel substrates with photo-controlled mechanical properties can allow one to probe the cellular response to localized variations in substrate viscoelasticity. Here, we...

Characterization of the RTG-lysine and RTG–AuNP hydrogels

Gold Nanoparticle-Functionalized Reverse Thermal Gel for Tissue Engineering Applications

Oct. 31, 2019

Utilizing polymers in cardiac tissue engineering holds promise for restoring function to the heart following myocardial infarction, which is associated with grave morbidity and mortality. To properly mimic native cardiac tissue, materials must not only support cardiac cell growth but also have inherent conductive properties. Here, we present an injectable...

 Sarcomeric structure and t-tubules are preserved in adult mouse cardiomyocytes cultured in 3D PEG hydrogels over time

Three-dimensional encapsulation of adult mouse cardiomyocytes in hydrogels with tunable stiffness

Oct. 22, 2019

Numerous diseases, including those of the heart, are characterized by increased stiffness due to excessive deposition of extracellular matrix proteins. Cardiomyocytes continuously adapt their morphology and function to the mechanical changes of their microenvironment. Because traditional cell culture is conducted on substrates that are many orders of magnitude stiffer than...

Morphological changes of encapsulated VICs in response to cytokine treatment.

FGF-2 inhibits contractile properties of valvular interstitial cell myofibroblasts encapsulated in 3D MMP-degradable hydrogels.

Oct. 22, 2019

Valvular interstitial cells (VICs) are responsible for the maintenance of the extracellular matrix in heart valve leaflets and, in response to injury, activate from a quiescent fibroblast to a wound healing myofibroblast phenotype. Under normal conditions, myofibroblast activation is transient, but the chronic presence of activated VICs can lead to...

Fig. 5 Post-TAVR serum deactivates valvular myofibroblasts activated with pre-TAVR serum on soft and stiff hydrogels.

Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation

Oct. 17, 2019

The transcatheter aortic valve replacement (TAVR) procedure has emerged as a minimally invasive treatment for patients with aortic valve stenosis (AVS). However, alterations in serum factor composition and biological activity after TAVR remain unknown. Here, we quantified the systemic inflammatory effects of the TAVR procedure and hypothesized that alterations in...

Rat cardiac fibroblasts—which happen to be in the shape of a heart—grown on hydrogels mimicking cardiac tissue and treated with human serum.

Mimicking the heart's microenvironment

Sept. 11, 2019

CU Boulder engineers and faculty from the Consortium for Fibrosis Research & Translation (CFReT) at the CU Anschutz Medical Campus have teamed up to develop biomaterial-based “mimics” of heart tissues to measure patients’ responses to an aortic valve replacement procedure, offering new insight into the ways that cardiac tissue re-shapes...

Kristi Anseth

Kristi Anseth elected to American Academy of Arts and Sciences

April 17, 2019

The American Academy of Arts and Sciences announced today that CU Boulder Professor Kristi Anseth has been elected to its 2019 class. Anseth is among more than 200 individuals selected this year for their exceptional achievements in the arts and sciences, business, philanthropy and the public sector. Founded in 1780,...

Chem Labs NMR Tubes

Eleven researchers earn prestigious 2018 Highly Cited designation

Nov. 28, 2018

Eleven CU Boulder researchers were honored in an annual report released by the firm Clarivate Analytics, which recognizes papers that rank in the top one percent of citations for their field and the year in its Web of Science platform. The CU Boulder researchers span a wide range of disciplines...


Personalized biomaterials tailor made to fix what ails you

Nov. 26, 2018

The complexities that make each of us unique could result in medications, surgeries or health care devices that treat only the symptoms but not the specific causes. At CU Boulder, engineers are inventing novel biomaterials able to decrease pain and extend life when the body gets out of kilter. And...