Students in the program take two formal courses, three credits each, of which one must be BCHM 5801. Additional electives listed are of particular interest to students in the SCR training program.
Lecture and discussion of current research in signal transduction, emphasizing molecular biology, biochemistry, and genetics. Topics include receptors and signaling pathways, control of transcription, DNA replication, epigenetics, development, and cell cycle progression.
Responsible Conduct of Research (1 credit):
BCHM 5776: All Biochemistry graduate students take RCR/BCHM 5776 in Fall semester of year 1, taught by the instructors in CORE.
GRAD 5000: All MCDB graduate students take RCR/GRAD 5000 in Fall semester of year 2, taught by Instructor Dr. Mary Allen and faculty discussion leaders.
All SCR students are required to complete refresher training after four years, which can be fulfilled by a 2-day RCR Refresher Training Course, which is offered most spring semesters. Alternatively, refresher training can be fulfilled by retaking BCHM 5776 or GRAD 5000.
Journal club for review of literature in signal transduction, transcription, cell cycle progression, and cell differentiation. Students are required to take two semesters of this course.
This lab course covers fundamental statistical and computational approaches to large scale data. Students will use the unix command line to browse publicly available genome data, learn how to apply statistical analysis to different data types, and use these skills to investigate regions of interest in the human genome.
Lecture and discussion on fundamentals of protein and nucleic acid structure, purification, folding, thermodynamics and biophysical methods for measurement (Elective for MCDB majors).
Lecture and discussion of cellular regulation, including transcription, replication, chromatin structure and modulation, cell cycle regulation, and intercellular communication (Elective for MCDB majors).
Lecture and discussion of cellular structure and ultrastructure, methods in microscopy and structure determination, with focus on literature review and critical analysis (Elective for Biochemistry majors).
Lecture and discussion of gene regulation and expression, examined by genetics and molecular, cellular and developmental biology, including DNA structure/function, RNA, regulatory proteins, human genetic diseases and gene therapy (Elective for Biochemistry majors).
This class explores the fundamentals of optical imaging in biology. Covered topics include an introduction to optics and microscopes, fluorescence microscopy, and an introduction to image analysis and coding in MATLAB.
An exploration of several of the most exciting topics in and basic biology and biomedicine, including protein folding and stress responses, nutrient sensing and balance, and signal transduction across membranes. Emphasis will be placed upon human physiology and disease, including Alzheimer's, diabetes, and cardiovascular disease.
A survey in bioinformatic algorithms and technological developments that have enbaled the field of genomics to impact diverse fields of biology, including cell biology, evolution, population genetics, and human disease.
Course covers the fundamentals of stem cell biology, including properties of stem cells, technology used to identify and study stem cells, current controversies and future directions in stem cell research.
A 9-day summer workshop introducing students to sequencing pipelines, data analysis, quality control, read mapping, and Genome Browser Visualization. The workshop also covers basic data analysis seen with popular sequencing techniques, including ChIP-seq, RNA-seq, ATAC-seq, DNA-seq, and single-cell sequencing.