Research

Adrianne Rosales ( now at University of Texas ) uses hydrogels with photocleavable and photopolymerizable functional groups to investigate the response of mesenchymal stem cells to changing mechanical environments. Head over to Angewandte Chemie to check it out !Read more »

Interested in how photochemical reactions can be used to create and modify biomaterials? Head over to Chemical Society Reviews and check out the latest review!Read more »

Alex Caldwell publishes a synthetic bottom-up fabrication process for microgel building blocks with clickable surface groups to make porous cell-laden scaffolds. Follow this link to read the full maunscript !Read more »

Hao Ma and Anouk Killaars co-authored this work appearing in Biomaterials. In this paper, they investigated the role of spatial variations in matrix elasticity and its organization on myofibroblastic activation on valvular interstitial cells. Check out the full article here !Read more »

In this work, Della develops fluorescent microgel sensors for the three-dimensional monitoring of cellular protease activity. These sensors are then used to monitor protease activity of melanoma cancer cells. Check out the full article here!Read more »

Congratulations to Michael and Adrianne for publishing one of the most accessed articles of 2016 in Journal of Materials Chemistry B . Find the full list here .Read more »

Ian Marozas and Tobin Brown co-authored this work, appearing online today in Advanced Materials . In this report, they investigate the use of reversible thiol-ene radical chemistry to rapidly photodegrade cell-laden hydrogels.Read more »

In this work, Emi Tokuda (currently at the Seattle Children's Hospital) investigates the effect of culture conditions, including dimensionality and cell-cell contacts, on the responsiveness of early- and late-stage melanoma cell lines towards cancer drugs. Find it here .Read more »

In this paper, former undergraduate research Michael Nehls and postdoc Adrianne Rosales demonstrate control over release kinetics of a model peptide drug based on a photo-switchable host/guest interaction between azobenzene and cyclodextrin. Check it out here !Read more »

This excellent review summarizes many of the techniques used to make reversible hydrogels. Whether the reversibility is in the crosslinks themselves, or in pendant functional groups, these gels have many interesting and exciting properties. Check it out online here .Read more »