AFM Novak Cover Image  AFM Novak Cover Image 2  Handbook of Imaging Cover Image  Magnetic Resonance Magazine Cover Image


    Google Scholar Link


    • Novak T., Seelbinder B., Twitchell C.M., Voytik-Harbin S.L., Neu C.P. (2016). Dissociated and reconstituted cartilage microparticles in densified collagen induce local hMSC differentiation. Advanced Functional Materials 26(30):5427-5436.
    • Novak T., Seelbinder B., Twitchell C.M., van Donkelaar C.C., Voytik-Harbin S.L., Neu C.P. (2016). Mechanisms and microenvironment investigation of cellularized high density gradient collagen matrices via densification. Advanced Functional Materials 26(16):2617-2628.
    • Xu X., Li X., Cai L., Calve S., Neu C.P. (2016). Mapping the nonreciprocal micromechanics of individual cells and the surrounding matrix within living tissues. Scientific Reports 6:24727.
    • Chan D.D., Cai L., Butz K.D., Trippel S.B., Nauman E.A., Neu C.P. (2016). In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee. Scientific Reports 6:19220.
    • Xu X., Li Z., Leng Y., Neu C.P., Calve S. (2016). Knockdown of the pericellular matrix molecule perlecan lowers in situ cell and matrix stiffness in developing cartilage. Developmental Biology (in press).
    • Novak T., Fites K., Xu X., Worke L., Ciesielski A., Breur G., Neu C.P. (2016). In vivo cellular infiltration and remodeling in a decellularized ovine osteochondral allograft. Tissue Engineering, Part A (in press).
    • Kim W., Ferguson V.L., Borden M., Neu C.P. (2016). Application of elastography for the noninvasive assessment of biomechanics in engineered biomaterials and tissues. Annals of Biomedical Engineering 44(3):705-24.
    • Blum K.M., Novak T., Neu C.P., Wallace J., Bart Z., Voytik-Harbin S.L. (2016). Acellular and cellular high-density, collagen-fibril constructs with suprafibrillar organization. Biomaterials Science 4(4):711-23.
    • Kaplan J.T., Neu C.P., Drissi H., Emery N.C., Pierce D.M. (2016). Cyclic loading of human articular cartilage: the transition from compaction to fatigue. Journal of the Mechanical Behavior of Biomedical Materials (in press).


    • Lawrence A., Xu X., Bible M.D., Calve S., Neu C.P., Panitch A. (2015). Synthesis and characterization of a lubricin mimic (mLub) to reduce friction and adhesion on the articular cartilage surface. Biomaterials 73:42-50.
    • Calve S., Ready A., Main R., Neu C.P. (2015). Optical clearing in dense connective tissues for in situ and systemwide cellular connectivity. PLoS ONE 10(1):e0116662.
    • Shannon G, Novak T., Mousoulis C., Voytik-Harbin S.L., Neu C.P. (2015). Temperature and concentration dependent fibrillogenesis for improved magnetic alignment of collagen gels. RSC Advances 5:2113-2121.
    • Neu C.P., Novak T., Gilliland K.F., Marshall P., Calve S. (2015). Optical clearing in collagen- and proteoglycan-rich osteochondral tissues. Osteoarthritis & Cartilage 23(3):405-13.
    • Ashinsky B.G., Coletta C.E., Lukas V.A., Boyle J.M., Bouhrara M., Reiter D.A., Neu C.P., Goldberg I.L., Spencer R.G. (2015). Machine learning classification of OARSI-scored human articular cartilage using magnetic resonance imaging. Osteoarthritis & Cartilage 23(10):1704-12.
    • Lukas V.A., Fishbein K.W., Lin P.-C., Schär M., Neu C.P., Spencer R.G., Reiter D.A. (2015). Classification of OARSI scored human articular cartilage explants by quantitative analysis of magnetic resonance images at 3T. Journal of Orthopaedic Research 33(5):640-50.
    • Novak T., Voytik-Harbin S.L., Neu C.P. (2015). Cell encapsulation in a magnetically aligned collagen-GAG copolymer microenvironment. Acta Biomaterialia 11:274-82.


    • Neu C.P. (2014). Functional Imaging in OA: Role of Imaging in the Evaluation of Tissue Biomechanics. Osteoarthritis & Cartilage 22(10):1349-1359.
    • Chan D.D., Gossett P.C., Butz K.D., Nauman E.A., Neu C.P. (2014). Comparison of intervertebral disc displacements measured under applied loading with MRI at 3.0T and 9.4T. Journal of Biomechanics 47(11):2801-6.
    • Griebel A., Trippel S.B., Emery N.C., Neu C.P. (2014). Noninvasive assessment of human osteoarthritis severity by multicontrast magnetic resonance imaging. Magnetic Resonance in Medicine 71(2):807-814.
    • Griebel A.J., Khoshgoftar M., Novak T., van Donkelaar C.C., Neu C.P. (2014). Direct noninvasive measurement and numerical modeling of depth-dependent strains in layered agarose constructs. Journal of Biomechanics – Special Issue on Functional Tissue Engineering 47(9):2149-56.
    • Chan D.D., Neu C.P. (2014). Intervertebral disc internal deformation measured by displacements under applied loading with MRI (dualMRI) at 3T. Magnetic Resonance in Medicine 71(3):1231-7.


    • Henderson J.T., Shannon G., Veress A., Neu C.P. (2013). Direct measurement of intranuclear strain distributions and RNA synthesis in single cells embedded within native tissue. Biophysical Journal 105(10):2252-2261.
    • Mousoulis C., Maleki T., Ziaie B., Neu C.P. (2013). Atomic force microscopy-coupled microcoils for cellular-scale nuclear magnetic resonance spectroscopy. Applied Physics Letters 102, 143702.
    • Lim K.Y., Henderson J.T., Neu C.P. (2013). Cell and tissue deformation measurements: texture correlation with third-order approximation of displacement gradients. Journal of Biomechanics 46(14):2490-6.
    • Mousoulis C., Xu X., Reiter D.A., Neu C.P. (2013). Single cell spectroscopy: noninvasive measures of small-scale structure and function. Methods 64(2):119-128. (Invited)
    • Griebel A., Trippel S.B., Neu C.P. (2013). Noninvasive dualMRI-based strains vary by depth and region in human osteoarthritic articular cartilage. Osteoarthritis and Cartilage 21(2):394-400.
    • Chan D.D., Neu C.P. (2013). Probing articular cartilage damage and disease using quantitative MRI. Journal of the Royal Society Interface 10(78):20120608.
    • Sharma S., Panitch A., Neu C.P. (2013). Incorporation of an aggrecan mimic prevents proteolytic degradation of anisotropic cartilage analogs. Acta Biomaterialia 9(1):4618-25.
    • Chan D.D., Toribio D., Neu C.P. (2013). Displacement smoothing for the precise MRI-based measurement of strain in soft biological tissues. Computer Methods in Biomechanics and Biomedical Engineering 16(8):852-60.


    • Chan S.M.T., Neu C.P., Komvopoulos K., Reddi A.H. (2012). Tribological altruism: a sacrificial layer mechanism of synovial joint lubrication. Journal of Biomechanics 45(14):2426-31.
    • Chan D.D. and Neu C.P. (2012). Transient and microscale deformations and strains measured during exogenous loading by noninvasive magnetic resonance. PLoS ONE 7(3):e33463.
    • Butz K.D., Griebel A., Novak T., Kornokovich A., Chiappetta M., Neu C.P. (2012). Prestress as an optimal biomechanical parameter for needle penetration. Journal of Biomechanics 45(7):1176-9.


    • Butz K.D., Chan D.D., Nauman E.A., Neu C.P. (2011). Stress distributions determined in articular cartilage by MRI-based finite strain. Journal of Biomechanics 44(15):2667-72.
    • Chan D.D., Van Dyke W.S., Bahls M., Connell S.D., Critser P., Kelleher J.E., Kramer M.A., Pearce S.M., Sharma S., Neu C.P. (2011). Mechanostasis in apoptosis and medicine. (2011). Progress in Biophysics and Molecular Biology 106(3):517-24.
    • Chan D.D., Khan S., Jing X., Klienberg E., Gupta M., Neu C.P. (2011). Displacement and GAG fields in a rabbit intervertebral disc degeneration model. SPINE. 36(18):1438-45.
    • To N.M., Curtiss S., Neu C.P., Salgado C.J., Jamali A.A. (2011). A new model of osteochondral allograft transplantation: the rabbit trochlea. Comparative Medicine 61(5):427-35.
    • Chan S.M.T., Neu C.P., Komvopoulos K., Reddi A.H., Di Cesare P.E. (2011). Friction and wear of hemiarthroplasty biomaterials in reciprocating sliding contact with articular cartilage. Journal of Tribology 133(4):041201.
    • Chan S.M.T., Neu C.P., Komvopoulos K., Reddi A.H. (2011). The role of lubricant entrapment at biological interfaces: reduction of friction and adhesion in articular cartilage. Journal of Biomechanics 44(11):2015-20.
    • Chan S.M.T., Neu C.P., Komvopoulos K., Reddi A.H. (2011). Dependence of nanoscale friction and adhesion properties of articular cartilage on contact load. Journal of Biomechanics 44(7):1340-5.
    • June R.K., Neu C.P., Barone J.R., Fhyrie D.P. (2011). Polymer mechanics as a model for short-term and flow-independent cartilage viscoelasticity. Materials Science and Engineering C 31(4):781-8.
    • Van den Bogaerde J.M., Shin E., Neu C.P., Marder R.A. (2011). The superficial medial collateral ligament reconstruction of the knee: effect of altering graft length on knee kinematics and stability. Knee Surg Sports Traumatol Arthrosc 19 Suppl 1:S60-8.
    • Patel R., Neu C.P., Curtiss S., Yoo B. (2011). Biomechanical comparison of large fragment versus small fragment fixation for humeral shaft fractures. Journal of Orthopaedic Trauma 25(5):300-5.


    • Neu C.P., Komvopoulos K., Reddi A.H., Schmid T.M., Di Cesare, P.A. (2010). Friction Coefficient and Superficial Zone Protein are Increased in Patients with Advanced Osteoarthritis. Arthritis and Rheumatism 62(9):2680-7.
    • Chan S.M.T., Neu C.P., DuRaine G.D., Komvopoulos K., Reddi A.H. (2010). Atomic force microscope investigation of the boundary-lubricant layer in articular cartilage. Osteoarthritis and Cartilage 18(7):956-63.
    • Calafi L.A., Antkowiak T., Curtiss S., Neu C.P., Moehring D. (2010). A biomechanical comparison of the Surgical Implant Generation Network (SIGN) tibial nail with the standard hollow nail. Injury 41(7):973-7.
    • Roberto R.F., McDonald T., Curtiss S., Neu C.P., Kim K., Pennings F. (2010). Progressive circumferential ligament resection (decompression) in conjunction with cervical disc arthroplasty in a spondylotic spine model. SPINE 35(18):1676-83.


    • Neu C.P., Arastu H.F., Curtiss S., Reddi A.H. (2009). Functional evaluation of engineered tissue constructs by magnetic resonance imaging. Journal of Tissue Engineering and Regenerative Medicine 3(6):477-85.
    • Chan D.D., Neu C.P., Hull M.L. (2009). Deformation of articular cartilage in cyclically loaded tibiofemoral joints by displacement-encoded MRI. Osteoarthritis and Cartilage 17(11):1461-8.
    • Chan D.D., Neu C.P., Hull M.L. (2009). Articular Cartilage Deformation Determined in an Intact Tibiofemoral Joint by Magnetic Resonance Imaging. Magnetic Resonance in Medicine 61(4):989-93
    • DuRaine G.D., Neu C.P., Chan S.M.T., Komvopoulos K., June R.K., Reddi A.H., (2009). Regulation of friction coefficient of articular cartilage by TGF-beta and IL-1beta. Journal of Orthopaedic Research 27(2):249-56
    • Martin K.J., Neu C.P., Hull M.L. (2009). Steady state displacement response of whole human cadaveric knees in an MRI scanner. Journal of Biomechanical Engineering 131(8):081004.


    • Neu C.P., Komvopoulos K., Reddi A.H. (2008). The interface of functional biotribology and regenerative medicine in synovial joints. Tissue Engineering, Part B: Reviews 14(3):235-47.
    • Neu C.P. and Stewart M. (2008). On the horizon from the ORS: Visualizing tissue deformation by noninvasive MRI. Journal of the American Academy of Orthopaedic Surgeons 16(7):432-434.
    • Neu C.P., Walton J.H. (2008). Displacement encoding for the measurement of cartilage deformation. Magnetic Resonance in Medicine 59(1):149-55


    • Martin K.J., Neu C.P., Hull M.L. (2007). An MRI-based method to align the compressive loading axis for human cadaveric knees. Journal of Biomechanical Engineering 129(6):855-862
    • Neu C.P., Khalafi A., Komvopoulos K., Schmid T.M., Reddi A.H. (2007). Mechanotransduction of superficial zone protein by TGF-beta signaling. Arthritis and Rheumatism 56(11):3706-3714
    • Khalafi A., Schmid T.M., Neu C.P., Reddi A.H. (2007). Stimulation of the expression of superficial zone protein (SZP) in articular cartilage by bone morphogenetic proteins and growth factors. Journal of Orthopaedic Research 25(3):293-303


    • Neu C.P., Hull M.L., Walton J.H. (2005). Error optimization of a three-dimensional MRI tagging-based cartilage deformation technique. Magnetic Resonance in Medicine 54(5):1290-1294
    • Neu C.P., Hull M.L., Walton J.H. (2005). Heterogeneous three-dimensional strain fields during unconfined cyclic compression in bovine articular cartilage explants. Journal of Orthopaedic Research 23(6):1390-1398
    • Neu C.P., Hull M.L., Walton J.H., Buonocore M.H. (2005). An MRI-based technique for determining nonuniform deformations throughout the volume of articular cartilage explants. Magnetic Resonance in Medicine 53(2):321-328
    • Roos P.J., Neu C.P., Hull M.L., Howell S.M. (2005). A new tibial coordinate system improves the precision of anterior–posterior knee laxity measurements: a cadaveric study using Roentgen stereophotogrammetric analysis. Journal of Orthopaedic Research 23(3):327-333


    • Neu C.P., Hull M.L. (2003). Toward an MRI-based method to measure three-dimensional cartilage deformation: an MRI-cyclic loading apparatus system and steady-state cyclic displacement of articular cartilage under compressive loading. Journal of Biomechanical Engineering 125(2):180-188
    • Crisco J.J., Wolfe S.W., Neu C.P., Pike S. (2001). Advances in the in vivo measurements of carpal kinematics. Orthopaedic Clinics of North America 32(2):219-231
    • Neu C.P., Crisco J.J., Wolfe S.W. (2001). In vivo kinematic behavior of the radio-capitate joint during wrist flexion-extension and radio-ulnar deviation. Journal of Biomechanics 34(11):1429-38
    • Wolfe S.W., Neu C.P., Crisco J.J. (2000). In vivo scaphoid, lunate, and capitate kinematics in flexion and in extension. Journal of Hand Surgery [American] 25(5):860-9
    • Neu C.P., McGovern R.D., Crisco J.J. (2000). Kinematic accuracy of three surface registration methods in a three-dimensional wrist bone study. Journal of Biomechanical Engineering 122(5):528-33


    Neu C.P. and Genin G. (Eds.) (2014) Handbook of Imaging in Biological Mechanics. CRC Press. ISBN 9781466588134

    Book Chapters

    • Cai L., Neu C.P., Pierce D.M. (2016). Combining Multi-Modal MR Imaging and Biomechanical Modeling to Investigate the Response of Cartilage and Chondrocytes to Mechanical Stimuli. In: Biophysics and Biochemistry of Cartilage by NMR and MRI. Ed. Xia and Momot. (in press)
    • Butz K.D., Chan D.D., Neu C.P., Nauman E.A. (2014). Noninvasive determination of material properties for biological materials. In: Handbook of Imaging in Biological Mechanics. Ed. Neu and Genin. ISBN 9781466588134
    • Neu C.P. (2014). dualMRI in soft biomaterials and tissues. In: Handbook of Imaging in Biological Mechanics. Ed. Neu and Genin. ISBN 978146658813
    • Henderson J.T., Neu C.P. (2014). Intranuclear measurement of deformation in single cells. In: Handbook of Imaging in Biological Mechanics. Ed. Neu and Genin.  ISBN 9781466588134
    • Thote T., Willett N., Moran S., Mirthy N., Neu C.P., Guldberg R.E. (2013). Imaging of osteoarthritic joints. In: Biomedical Imaging: Applications and Advances. Ed. Peter Morris. ISBN 9780857091277