genes

Chimeric Cas12a-type Nucleases for CRISPR Gene Editing

Nov. 17, 2021

New CRISPR/Cas12a-type nucleases with improved characteristics for targeted editing.

Switchable Phase Change Material Systems for Building Envelopes

Switchable Phase Change Material Systems for Building Envelopes

Nov. 17, 2021

A system that helps enhance energy performance in building by allowing building envelope assemblies to store energy from one side and release it to the other side.

Low-loss, high-bandwidth, robust fiber-to-chip couplers

Low-loss, high-bandwidth, robust fiber-to-chip couplers

Oct. 21, 2021

Integrated photonics’ major challenge is the efficient coupling of standard optical fiber to on-chip photonics waveguides and devices. Coupling devices must connect vastly different sized modes while preventing loss of light. This adiabatically tapered fibers coupler is unsuspended and obtains low loss over a large optical bandwidth.

Dynamic Photovoltaic (PV)-integrated overhangs

Dynamic photovoltaic (PV)-integrated overhangs

Oct. 21, 2021

In the US, windows are responsible for 12% of the total energy consumed by the existing US residential and commercial buildings due mostly to uncontrolled solar heat gains. Researchers at CU Boulder have developed PV arrays with sliding overhangs to both generate electricity and reduce heating and cooling thermal loads.

Think Bioscience

Think Bioscience

Sept. 20, 2021

With unique platform technology that combines applied microbiology, enzymology and data science, Think Bioscience is developing small-molecule therapeutics against challenging targets.

cement pour

Acid-Resistant Inorganic Composite

Aug. 18, 2021

Researchers at the University of Colorado have developed a method to create an acid-resistant inorganic coating to be applied to concrete sewer pipe conduit. The inorganic cements are made from a low-calcium metakaolin-based alkali-activated cement (AAC). The cements are doped with inorganic polyvalent cations (e.g., magnesium, iron, copper, cobalt), resulting in even lower permeable porosities and smaller acid corrosion depths compared to ordinary portland cement (OPC).

cancer cells

Novel selective HDAC6 inhibitors: A promising therapy approach for cancer and beyond

Aug. 4, 2021

Histone deacetylases (HDACs) are important epigenetic regulators, which impact chromatin condensation and gene expression. Tumor development has been linked to HDAC gene mutations and altered expression of HDACs. Therefore, inhibitors of histone deacetylase enzymes (HDACi) have been developed as potential cancer therapeutics. The researchers of the University of Colorado developed a series of hydroxamic acid derivatives as HDAC6 selective inhibitors. There is extensive national and international patent coverage for this technology.

STED technology

Stimulated emission depletion (STED) microscopy with polarization-maintaining fiber

July 28, 2021

Researchers at the University of Colorado have come up with a method for STED microscopy of a fluorescent species in an object to be imaged, the fluorescent excitation wavelength a fluorescence depletion wavelength and a fluorescence emission wavelength. This makes for a more accurate examination where subjects are free to move naturally possible.

Chemical depolymerization methods for depolymerization of poly(ethylene terephthalate) (PET)

Methods for chemical degradation of polyester polymers

June 30, 2021

Even though poly(ethylene terephthalate) (PET) is generally the most recovered plastic, the amount of waste PET that is recycled is still low, especially given the scale of use. The most commonly reported reason for the lack of recycling is the inaccessibility to recycling resources, and there is therefore a need for a more accessible way of sustainably recycling PET. CU Boulder researchers have produced new methods for the chemical recycling of end-use PET in batch, microwave and electrochemical reactors.

Monolithic Mode-Locked Laser

Monolithic mode-locked laser

June 30, 2021

Mode-locked lasers are imperative for the generation and application of coherent optical frequency combs. Low noise is necessary for many applications. However, the current super low noise MLLs are massive lab-bench systems and unusable in industry applications. This technology is an extremely low-noise, low-power and high-repetition rate mode-locked laser.

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