Structure of the complete human pre-initiation complex (PIC)
from: Richter et al. Nat Rev Mol Cell Biol 2022 732
Dynamic structure of the human Mediator complex
from: Richter et al. Nat Rev Mol Cell Biol 2022 732
Regulation of CDK7 kinase by TFIIH complex
from: Rimel et al. Genes Dev 2020 1452
TFIID-dependent regulation of RNA polymerase II promoter-proximal pausing
from: Fant et al. Mol Cell 2020 785
Model and overview of human RNA polymerase II Pre-initiation complex (PIC)
from: Schier & Taatjes Genes Dev 2020 465
Mediator interaction with the TFIIF–RNA polymerase II complex
adapted from Bernecky et al. PLoS Biol 2011 e1000603
CDK8 module association with Mediator bound to enhancer DNA
adapted from Knuesel et al. Genes Dev 2009 439 & Taatjes et al. Science 2002 1058
TF-induced structural changes in Mediator: the p53-Mediator complex
from Meyer et al. Nat Struct Mol Biol 2010 753
TF-induced structural changes in Mediator: the SREBP-Mediator complex
from Taatjes et al. Science 2002 1058
These animations are based upon existing structural data and were generated though an NSF-supported collaboration with Shraddha Nayak and Janet Iwasa (University of Utah).