molecular animations

Structure of the complete human pre-initiation complex (PIC)

from: Richter et al. Nat Rev Mol Cell Biol 2022 732

Dynamic structure of the human Mediator complex

from: Richter et al. Nat Rev Mol Cell Biol 2022 732

Regulation of CDK7 kinase by TFIIH complex

from: Rimel et al. Genes Dev 2020 1452

TFIID-dependent regulation of RNA polymerase II promoter-proximal pausing

from: Fant et al. Mol Cell 2020 785

Model and overview of human RNA polymerase II Pre-initiation complex (PIC)

from: Schier & Taatjes Genes Dev 2020 465

Mediator interaction with the TFIIF–RNA polymerase II complex

adapted from Bernecky et al. PLoS Biol 2011 e1000603

CDK8 module association with Mediator bound to enhancer DNA

adapted from Knuesel et al. Genes Dev 2009 439 & Taatjes et al. Science 2002 1058

TF-induced structural changes in Mediator: the p53-Mediator complex

from Meyer et al. Nat Struct Mol Biol 2010 753

TF-induced structural changes in Mediator: the SREBP-Mediator complex

from Taatjes et al. Science 2002 1058

These animations are based upon existing structural data and were generated though an NSF-supported collaboration with Shraddha Nayak and Janet Iwasa (University of Utah).