Tang H, Cui M, Han M. Fatty acids impact sarcomere integrity through myristoylation and ER homeostasis. Cell Reports. 2021. In Press

Sewell AK and Han M. Learning from the worm: the effectiveness of protein-bound Moco to treat Moco deficiency. Genes & Development. 2021 Feb 1. 35: 177-179; doi:10.1101/gad.348176.120. PDF

Weaver BP, Weaver YM, Omi S, Yuan W, Ewbank JJ, Han M. Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development. Developmental Cell. 2020 Apr 8. pii: S1534-5807(20)30224-0. PDF  PMID: 32302544

Jia F, Chi C, Han M. Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease. Cell Reports. 2020 Feb 11;30(6):1848-1861.e5. PMID: 32049015

Blackwell TK, Sewell AK, Wu Z, Han M. TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging. WormBook Chapter. Genetics. 2019. doi: https://doi.org/10.1534/genetics.119.302504. PMID: 31594908

Mao K, Ji F, Breen P, Sewell AK, Han M, Sadreyev R, Ruvkun G. Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes. Cell Metab. 2019 Feb 14. pii: S1550-4131(19)30022-1. doi: 10.1016/j.cmet.2019.01.022. PMID: 30799287

Sewell AK, Han M, Qi B. An unexpected benefit from E. coli: how enterobactin benefits host health. Microbial Cell. 2018. page 469-471 doi: 10.15698/mic2018.10.653. PMID: 30386791

Qi B, Han M. Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase. Cell. 2018 Aug 16. pii: S0092-8674(18)30959-0. https://doi.org/10.1016/j.cell.2018.07.032 PMID: 30146159

Weaver B, Han M. Tag team: Roles of miRNAs and Proteolytic Regulators in Ensuring Robust Gene Expression Dynamics. Trends Genet. 2017 Oct 13. pii: S0168-9525(17) 30169-5. doi: 10.1016/j.tig.2017.09.009. PMID: 29037438

Weaver B, Weaver Y, Mitani S, Han M. Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development. Dev Cell. 2017 Jun 19;41(6):665-673.e6. doi: 10.1016/j.devcel.2017.05.013. PMID: 28602583

Zabinsky RA, Weum B, Cui M, Han M. RNA Binding Protein Vigilin Collaborates with miRNAs To Regulate Gene Expression for Caenorhabditis elegans Larval Development. G3 (Bethesda). 2017 Jun 2. pii: g3.117.043414. doi: 10.1534/g3.117.043414. PMID: 28576776

Qi B, Kniazeva M, Han M. A vitamin B2 sensing mechanism that regulates gut protease activity to impact animal's food behavior and growth. Elife. 2017 Jun 1;6. pii: e26243. doi: 10.7554/eLife.26243. PMID: 28569665

Tang H, Han M. Fatty Acids Regulate Germline Sex Determination through ACS-4-Dependent Myristoylation. Cell. 2017 Apr 20;169(3):457-469.e13. doi: 10.1016/j.cell.2017.03.049. PMID: 28431246

  • Faculty of 1000 Exceptional
  • Reported by several media outlets

Zhu X, Xie S, Xu T, Wu X, Han M. Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders. Mol Metab. 2017 Mar 18;6(6):494-502. doi: 10.1016/j.molmet.2017.03.003. eCollection 2017 Jun. PMID: 28580280

Cui M, Wang Y, Cavaleri J, Kelson T, Teng Y, Han M. Starvation-Induced Stress Response Is Critically Impacted by Ceramide Levels in Caenorhabditis elegans. Genetics. 2017 Feb;205(2):775-785. doi: 10.1534/genetics.116.194282. PMID: 27974500; PMCID: PMC5289851

Cui J, Ding Y, Chen S, Zhu X, Wu Y, Zhang M, Zhao Y, Li TR, Sun LV, Zhao S, Zhuang Y, Jia W, Xue L, Han M, Xu T, Wu X. Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. J Clin Invest. 2016 Sep 1;126(9):3192-206. doi: 10.1172/JCI85676. PMID: 27500489; PMCID: PMC5004970

Weaver BP, Sewell AK, Han M. Time to move the fat. Genes Dev. 2016 Jul 1;30(13):1481-2. doi: 10.1101/gad.285460.116. PMID: 27401550; PMCID: PMC4949320.

Wang G, Li R, Yang Y, Cai L, Ding S, Xu T, Han M, Wu X. Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice. Cell Biosci. 2016 Jun 10;6:41. doi: 10.1186/s13578-016-0108-4. PMID: 27293546; PMCID: PMC4902905.

Ye Z, Sun L, Li R, Han M, Zhuang Y, Wu X, Xu T. Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy. Int J Biol Sci. 2016 Jun 7;12(8):911-6. doi: 10.7150/ijbs.15172. PMID: 27489495; PMCID:4971730.

Chi C, Han M. Notch signaling protects animals from nucleotide deficiency. Cell Cycle. 2016 Aug 2;15(15):1941-2. doi: 10.1080/15384101.2016.1181878. PMID: 27111808. PMCID: PMC4968961.

Jia F, Cui M, Than MT, Han M. Developmental Defects of Caenorhabditis elegans Lacking Branched-chain α-Ketoacid Dehydrogenase Are Mainly Caused by Monomethyl Branched-chain Fatty Acid Deficiency. J Biol Chem. 2016 Feb 5;291(6):2967-73. doi: 10.1074/jbc.M115.676650. Epub 2015 Dec 18. PMID: 26683372; PMCID: PMC4742758.

Chi C, Ronai D, Than MT, Walker CJ, Sewell AK, Han M. Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans. Genes Dev. 2016 Feb 1;30(3):307-20. doi: 10.1101/gad.275107.115. PMID: 26833730; PMCID: PMC4743060.

Han M. Twists and turns--How we stepped into and had fun in the "boring" lipid field. Sci China Life Sci. 2015 Nov;58(11):1073-83. doi: 10.1007/s11427-015-4949-6. Epub 2015 Oct 28. PMID: 26511515.

Zhu H, Sewell AK, Han M. Intestinal apical polarity mediates regulation of TORC1 by glucosylceramide in C. elegans. Genes Dev. 2015 Jun 15;29(12):1218-23. doi: 10.1101/gad.263483.115. PMID: 26109047; PMCID: PMC4495394.

Kniazeva M, Zhu H, Sewell AK, Han M. A Lipid-TORC1 Pathway Promotes Neuronal Development and Foraging Behavior under Both Fed and Fasted Conditions in C. elegans. Dev Cell. 2015 May 4;33(3):260-71. doi: 10.1016/j.devcel.2015.02.015. Epub 2015 Apr 16. PMID: 25892013.

Cohen ML, Kim S, Morita K, Kim SH, Han M. The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs. PLoS Genet. 2015 Mar 27;11(3):e1005099. doi: 10.1371/journal.pgen.1005099. eCollection 2015 Mar. Erratum in: PLoS Genet. 2015 May;11(5):e1005257. PMID: 25816370; PMCID: PMC4376641.

Weaver BP, Zabinsky R, Weaver YM, Lee ES, Xue D, Han M. CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans. Elife. 2014 Dec 30;3:e04265. doi: 10.7554/eLife.04265. PMID: 25432023; PMCID: PMC4279084.

Shi F, Ding S, Zhao S, Han M, Zhuang Y, Xu T, Wu X. A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice. Hum Mol Genet. 2014 Jul 15;23(14):3792-800. doi: 10.1093/hmg/ddu092. Epub 2014 Feb 23. PMID: 24565867.

Zhu H, Han M. Exploring developmental and physiological functions of fatty acid and lipid variants through worm and fly genetics. Annu Rev Genet. 2014;48:119-48. doi: 10.1146/annurev-genet-041814-095928. Epub 2014 Aug 25. Review. PMID: 25195508.

Than M, Han M. Functional analysis of the miRNA-mRNA interaction network in C. elegans. Worm. 2013 Oct 1;2(4):e26894. doi: 10.4161/worm.26894. Epub 2013 Oct 28. PMID: 24744982; PMCID: PMC3917963.

Cui M, Cohen ML, Teng C, Han M. The tumor suppressor Rb critically regulates starvation-induced stress response in C. elegans. Curr Biol. 2013 Jun 3;23(11):975-80. doi: 10.1016/j.cub.2013.04.046. Epub 2013 May 9. PMID: 23664972; PMCID: PMC3728909.

Than MT, Kudlow BA, Han M. Functional analysis of neuronal microRNAs in Caenorhabditis elegans dauer formation by combinational genetics and Neuronal miRISC immunoprecipitation. PLoS Genet. 2013 Jun;9(6):e1003592. doi: 10.1371/journal.pgen.1003592. Epub 2013 Jun 20. PMID: 23818874; PMCID: PMC3688502.

  • Faculty of 1000 recommendation

Zhu H, Shen H, Sewell AK, Kniazeva M, Han M. A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans. Elife. 2013 May 21;2:e00429. doi: 10.7554/eLife.00429. PMID: 23705068; PMCID: PMC3660743.

Li R, Zhuang Y, Han M, Xu T, Wu X. piggyBac as a high-capacity transgenesis and gene-therapy vector in human cells and mice. Dis Model Mech. 2013 May;6(3):828-33. doi: 10.1242/dmm.010827. Epub 2013 Mar 8. PMID: 23519027; PMCID: PMC3634665.

Kniazeva M, Han M. Fat chance for longevity. Genes Dev. 2013 Feb 15;27(4):351-4. doi: 10.1101/gad.214189.113. PMID: 23431052; PMCID: PMC3589552.

Wang R, Kniazeva M, Han M. Peroxisome protein transportation affects metabolism of branched-chain fatty acids that critically impact growth and development of C. elegans. PLoS One. 2013 Sep 27;8(9):e76270. doi: 10.1371/journal.pone.0076270. eCollection 2013. PMID: 24086720; PMCID: PMC3785516.

Lei K, Zhu X, Xu R, Shao C, Xu T, Zhuang Y, Han M. Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. Curr Biol. 2012 Sep 11;22(17):1609-15. doi: 10.1016/j.cub.2012.06.043. Epub 2012 Aug 2. PMID: 22863315; PMCID: PMC3466333. 

Morimoto A, Shibuya H, Zhu X, Kim J, Ishiguro K, Han M, Watanabe Y. A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. J Cell Biol. 2012 Jul 23;198(2):165-72. doi: 10.1083/jcb.201204085. PMID: 22826121; PMCID: PMC3410425.

Kudlow BA, Zhang L, Han M. Systematic analysis of tissue-restricted miRISCs reveals a broad role for microRNAs in suppressing basal activity of the C. elegans pathogen response. Mol Cell. 2012 May 25;46(4):530-41. doi: 10.1016/j.molcel.2012.03.011. Epub 2012 Apr 11. PMID: 22503424; PMCID: PMC3365535.

  • Faculty of 1000 recommendation

Kniazeva M, Shen H, Euler T, Wang C, Han M. Regulation of maternal phospholipid composition and IP(3)-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans. Genes Dev. 2012 Mar 15;26(6):554-66. doi: 10.1101/gad.187054.112. PMID: 22426533; PMCID: PMC3315117.

Wu X, Shi Z, Cui M, Han M, Ruvkun G. Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. PLoS Genet. 2012; 8(3):e1002542. doi: 10.1371/journal.pgen.1002542. Epub 2012 Mar 8. PMID: 22412383; PMCID: PMC3297578.

Zhang X, Zabinsky R, Teng Y, Cui M, Han M. microRNAs play critical roles in the survival and recovery of Caenorhabditis elegans from starvation-induced L1 diapause. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17997-8002. doi: 10.1073/pnas.1105982108. Epub 2011 Oct 19. PMID: 22011579; PMCID: PMC3207661.

Guo Z, Li H, Han M, Xu T, Wu X, Zhuang Y. Modeling Sjögren's syndrome with Id3 conditional knockout mice. Immunol Lett. 2011 Mar 30;135(1-2):34-42. doi: 10.1016/j.imlet.2010.09.009. PMID: 20932862; PMCID: PMC3025308.

Yu J, Lei K, Zhou M, Craft CM, Xu G, Xu T, Zhuang Y, Xu R, Han M. KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet. 2011 Mar 15;20(6):1061-73. doi: 10.1093/hmg/ddq549. Epub 2010 Dec 21. PMID: 21177258; PMCID: PMC3043658.

Zhang X, Han M. Nuclear migration: rock and roll facilitated by dynein and kinesin. Curr Biol. 2010 Dec 7;20(23):R1027-9. doi: 10.1016/j.cub.2010.10.047. PMID: 21145020.

Zhang C, Tian L, Chi C, Wu X, Yang X, Han M, Xu T, Zhuang Y, Deng K. Adam10 is essential for early embryonic cardiovascular development. Dev Dyn. 2010 Oct;239 (10):2594-602. doi: 10.1002/dvdy.22391. PMID: 20803506.

Kim S, Johnson W, Chen C, Sewell AK, Byström AS, Han M. Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans. Genetics. 2010 Aug;185(4):1235-47. doi: 10.1534/genetics.110.118406. Epub 2010 May 17. PMID: 20479142; PMCID: PMC2927752.

Chi C, Zhu H, Han M, Zhuang Y, Wu X, Xu T. Disruption of lysosome function promotes tumor growth and metastasis in Drosophila. J Biol Chem. 2010 Jul 9;285(28): 21817-23. doi: 10.1074/jbc.M110.131714. Epub 2010 Apr 25. PMID: 20418542; PMCID: PMC2898421.

Yi J, Chen M, Wu X, Yang X, Xu T, Zhuang Y, Han M, Xu R. Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. Dev Dyn. 2010 Jul;239(7):2005-13. doi: 10.1002/dvdy.22343. PubMed PMID: 20549726; PubMed Central PMCID: PMC3138404.

Lee KZ, Kniazeva M, Han M, Pujol N, Ewbank JJ. The fatty acid synthase fasn-1 acts upstream of WNK and Ste20/GCK-VI kinases to modulate antimicrobial peptide expression in C. elegans epidermis. Virulence. 2010 May-Jun;1(3):113-22. doi: 10.4161/viru.1.3.10974. PMID: 21178429; PMCID: PMC3073241.

Han M. Advancing biology with a growing worm field. Dev Dyn. 2010 May;239(5):1263-4. doi: 10.1002/dvdy.22291. PMID: 20419781.

Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, Xu R, Han M. SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron. 2009 Oct 29;64(2):173-87. doi: 10.1016/j.neuron.2009.08.018. PMID: 19874786; PMCID: PMC2788510.

Wu Y, Zhuang Y, Han M, Xu T, Deng K. Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye. BMC Dev Biol. 2009 Oct 20;9:53. doi: 10.1186/1471-213X-9-53. PMID: 19840402; PMCID: PMC2773777.

Yu J, Ying M, Zhuang Y, Xu T, Han M, Wu X, Xu R. C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice. Dev Dyn. 2009 Oct;238(10):2471-8. doi: 10.1002/dvdy.22063. PMID: 19681162.

Dong Y, Du X, Ye J, Han M, Xu T, Zhuang Y, Tao W. A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol. 2009 Sep 15;183(6):3865-72. doi: 10.4049/jimmunol.0900678. Epub 2009 Aug 19. PMID: 19692642.

Zhang L, Hammell M, Kudlow BA, Ambros V, Han M. Systematic analysis of dynamic miRNA-target interactions during C. elegans development. Development. 2009 Sep;136(18):3043-55. doi: 10.1242/dev.039008. Epub 2009 Aug 12. PMID: 19675127; PMCID: PMC2730362.

Green RM, Gally F, Keeney JG, Alper S, Gao B, Han M, Martin RJ, Weinberger AR, Case SR, Minor MN, Chu HW. Impact of cigarette smoke exposure on innate immunity: a Caenorhabditis elegans model. PLoS One. 2009 Aug 31;4(8):e6860. doi: 10.1371/journal.pone.0006860. PMID: 19718433; PMCID: PMC2729919.

Seamen E, Blanchette JM, Han M. P-type ATPase TAT-2 negatively regulates monomethyl branched-chain fatty acid mediated function in post-embryonic growth and development in C. elegans. PLoS Genet. 2009 Aug;5(8):e1000589. doi: 10.1371/journal.pgen.1000589. Epub 2009 Aug 7. PMID: 19662161; PMCID: PMC2716530.

Lei K, Zhang X, Ding X, Guo X, Chen M, Zhu B, Xu T, Zhuang Y, Xu R, Han M. SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10207-12. doi: 10.1073/pnas.0812037106. Epub 2009 Jun 9. PMID: 19509342; PMCID: PMC2700906.

Xu R, Deng K, Zhu Y, Wu Y, Ren J, Wan M, Zhao S, Wu X, Han M, Zhuang Y, Xu T. A large-scale functional approach to uncover human genes and pathways in Drosophila. Cell Res. 2008 Nov;18(11):1114-27. doi: 10.1038/cr.2008.295. PMID: 18957936.

Cui M, Allen MA, Larsen A, Macmorris M, Han M, Blumenthal T. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16665-70. doi: 10.1073/pnas.0807104105. Epub 2008 Oct 22. PMID: 18946043; PMCID: PMC2571909.

Tian L, Wu X, Chi C, Han M, Xu T, Zhuang Y. ADAM10 is essential for proteolytic activation of Notch during thymocyte development. Int Immunol. 2008 Sep;20(9):1181-7. doi: 10.1093/intimm/dxn076. Epub 2008 Jul 17. PMID: 18635581.

Hammell M, Long D, Zhang L, Lee A, Carmack CS, Han M, Ding Y, Ambros V. mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts. Nat Methods. 2008 Sep;5(9):813-9. doi: 10.1038/nmeth.1247. PMID: 19160516; PMCID: PMC3092588.

Kniazeva M, Euler T, Han M. A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C. elegans. Genes Dev. 2008 Aug 1;22(15):2102-10. doi: 10.1101/gad.1692008. PMID: 18676815; PMCID: PMC2492746.

Tucker M, Han M. Muscle cell migrations of C. elegans are mediated by the alpha-integrin INA-1, Eph receptor VAB-1, and a novel peptidase homologue MNP-1. Dev Biol. 2008 Jun 15;318(2):215-23. doi: 10.1016/j.ydbio.2008.02.062. Epub 2008 Mar 20. PMID: 18452914; PMCID: PMC2453148.

Sun L, Wu X, Han M, Xu T, Zhuang Y. A mitotic recombination system for mouse chromosome 17. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4237-41. doi: 10.1073/pnas.0800798105. Epub 2008 Mar 6. PMID: 18326030; PMCID: PMC2393783.

Sun LV, Jin K, Liu Y, Yang W, Xie X, Ye L, Wang L, Zhu L, Ding S, Su Y, Zhou J, Han M, Zhuang Y, Xu T, Wu X, Gu N, Zhong Y. PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice. Nucleic Acids Res. 2008 Jan;36:D729-34. Epub 2007 Oct 11. PMID: 17932058; PMCID: PMC2238892.

Zhang L, Ding L, Cheung TH, Dong MQ, Chen J, Sewell AK, Liu X, Yates JR 3rd, Han M. Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Mol Cell. 2007 Nov 30;28(4):598-613. PMID: 18042455; PMCID: PMC2186060.

Ding L, Han M. GW182 family proteins are crucial for microRNA-mediated gene silencing. Trends Cell Biol. 2007 Aug;17(8):411-6. Epub 2007 Sep 4. Review. PMID: 17766119.

Ding X, Xu R, Yu J, Xu T, Zhuang Y, Han M. SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Dev Cell. 2007 Jun;12(6):863-72. PMID: 17543860.

Cui M, Han M. Roles of chromatin factors in C. elegans development. WormBook. 2007 May 3:1-16. Review. PMID: 18050494.

Zhang X, Xu R, Zhu B, Yang X, Ding X, Duan S, Xu T, Zhuang Y, Han M. Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. Development. 2007 Mar;134(5):901-8. Epub 2007 Jan 31. PMID: 17267447.

  • Three Faculty of 1000 recommendations

Morita K, Han M. Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans. EMBO J. 2006 Dec 13;25(24):5794-804. Epub 2006 Nov 30. PMID: 17139256; PMCID: PMC1698897.

Wan M, Wu X, Guan KL, Han M, Zhuang Y, Xu T. Muscle atrophy in transgenic mice expressing a human TSC1 transgene. FEBS Lett. 2006 Oct 16;580(24):5621-7. Epub 2006 Sep 18. PMID: 16996505.

Ying M, Xu R, Wu X, Zhu H, Zhuang Y, Han M, Xu T. Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA. J Biol Chem. 2006 May 5;281(18):12580-6. Epub 2005 Dec 28. PMID: 16407196.

Cui M, Kim EB, Han M. Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans. PLoS Genet. 2006 May;2(5):e74. Epub 2006 May 19. PMID: 16710447; PMCID: PMC1463046.

Cui M, Chen J, Myers TR, Hwang BJ, Sternberg PW, Greenwald I, Han M. SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans. Dev Cell. 2006 May;10(5):667-72. PMID: 16678779.

  • Faculty of 1000 Exceptional, four highlight comments, FFa15

Suzuki Y, Han M. Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development. Genes Dev. 2006 Feb 15;20(4):423-8. PMID: 16481471; PMCID: PMC1369044.

Yu J, Starr DA, Wu X, Parkhurst SM, Zhuang Y, Xu T, Xu R, Han M. The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. Dev Biol. 2006 Jan 15;289(2):336-45. Epub 2005 Dec 7. PMID: 16337624.

Morita K, Hirono K, Han M. The Caenorhabditis elegans ect-2 RhoGEF gene regulates cytokinesis and migration of epidermal P cells. EMBO Rep. 2005 Dec;6(12):1163-8. PMID: 16170304; PMCID: PMC1369201.

Eastburn DJ, Han M. A gain-of-function allele of cbp-1, the Caenorhabditis elegans ortholog of the mammalian CBP/p300 gene, causes an increase in histone acetyltransferase activity and antagonism of activated Ras. Mol Cell Biol. 2005 Nov;25(21):9427-34. PMID: 16227593; PMCID: PMC1265831.

Tucker M, Sieber M, Morphew M, Han M. The Caenorhabditis elegans aristaless orthologue, alr-1, is required for maintaining the functional and structural integrity of the amphid sensory organs. Mol Biol Cell. 2005 Oct;16(10):4695-704. Epub 2005 Jul 29. PMID: 16055504; PMCID: PMC1237075.

Ding S, Wu X, Li G, Han M, Zhuang Y, Xu T. Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell. 2005 Aug 12;122(3): 473-83. PMID: 16096065.

Ding L, Spencer A, Morita K, Han M. The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans. Mol Cell. 2005 Aug 19;19(4):437-47. PMID: 16109369.

  • Developmental Cell mini-review
  • Featured article of the issue
  • First report on GW182 function in miRISC

Zhu H, Wang G, Li G, Han M, Xu T, Zhuang Y, Wu X. Ubiquitous expression of mRFP1 in transgenic mice. Genesis. 2005 Jun;42(2):86-90. PMID: 15880439.

Grady RM, Starr DA, Ackerman GL, Sanes JR, Han M. Syne proteins anchor muscle nuclei at the neuromuscular junction. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12): 4359-64. Epub 2005 Mar 4. PMID: 15749817; PMCID: PMC555524.

del Campo JJ, Opoku-Serebuoh E, Isaacson AB, Scranton VL, Tucker M, Han M, Mohler WA. Fusogenic activity of EFF-1 is regulated via dynamic localization in fusing somatic cells of C. elegans. Curr Biol. 2005 Mar 8;15(5):413-23. PMID: 15753035.

Starr DA, Han M. A genetic approach to study the role of nuclear envelope components in nuclear positioning. Novartis Found Symp. 2005;264:208-19; discussion 219-230. Review. PMID: 15773756.

Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan KL. Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci. 2004 Nov;7(11):1213-21. Epub 2004 Oct 17. PMID: 15494734; PMCID: PMC2373267.

Kniazeva M, Crawford QT, Seiber M, Wang CY, Han M. Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development. PLoS Biol. 2004 Sep;2(9):E257. Epub 2004 Aug 31. PMID: 15340492; PMCID: PMC514883.

  • Faculty of 1000 Exceptional, FFa10.0

Chen Z, Eastburn DJ, Han M. The Caenorhabditis elegans nuclear receptor gene nhr-25 regulates epidermal cell development. Mol Cell Biol. 2004 Sep;24(17):7345-58. PMID: 15314147; PMCID: PMC506989.

Cui M, Fay DS, Han M. lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans larval development. Genetics. 2004 Jul;167(3):1177-85. PMID: 15280233; PMCID: PMC1470958.

Eastburn D, Han M. When Ras signaling reaches the mediator. Dev Cell. 2004 Feb;6(2):158-9. PMID: 14960267.

Yoder JH, Chong H, Guan KL, Han M. Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. EMBO J. 2004 Jan 14;23(1):111-9. Epub 2003 Dec 11. PMID: 14685271; PMCID: PMC1271663.

Wang F, Yoder J, Antoshechkin I, Han M. Caenorhabditis elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis. Mol Cell Biol. 2003 Nov;23(21):7698-707. PMID: 14560015; PMCID: PMC207601.

Fay DS, Large E, Han M, Darland M. lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans. Development. 2003 Jul;130(14):3319-30. PMID: 12783801.

Cui M, Han M. Cis regulatory requirements for vulval cell-specific expression of the Caenorhabditis elegans fibroblast growth factor gene egl-17. Dev Biol. 2003 May 1;257(1):104-16. PMID: 12710960.

Starr DA, Han M. ANChors away: an actin based mechanism of nuclear positioning. J Cell Sci. 2003 Jan 15;116(Pt 2):211-6. Review. PMID: 12482907.

Kniazeva M, Sieber M, McCauley S, Zhang K, Watts JL, Han M. Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans. Genetics. 2003 Jan;163(1):159-69. PMID: 12586704; PMCID: PMC1462428.

Suzuki Y, Morris GA, Han M, Wood WB. A cuticle collagen encoded by the lon-3 gene may be a target of TGF-beta signaling in determining Caenorhabditis elegans body shape. Genetics. 2002 Dec;162(4):1631-9. PMID: 12524338; PMCID: PMC1462364.

Starr DA, Han M. Role of ANC-1 in tethering nuclei to the actin cytoskeleton. Science. 2002 Oct 11;298(5592):406-9. Epub 2002 Aug 8. PubMed PMID: 12169658.

  • Faculty of 1000 Must Read

Antoshechkin I, Han M. The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis. Dev Cell. 2002 May;2(5):579-91. PMID: 12015966.

Lee KK, Starr D, Cohen M, Liu J, Han M, Wilson KL, Gruenbaum Y. Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans. Mol Biol Cell. 2002 Mar;13(3):892-901. PMID: 11907270; PMCID: PMC99607.

Fay DS, Keenan S, Han M. fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen. Genes Dev. 2002 Feb 15;16(4):503-17. PMID: 11850412; PMCID: PMC155341.

  • Faculty of 1000 Must Read

Hanna-Rose W, Han M. The Caenorhabditis elegans EGL-26 protein mediates vulval cell morphogenesis. Dev Biol. 2002 Jan 15;241(2):247-58. PMID: 11784109.

Starr DA, Hermann GJ, Malone CJ, Fixsen W, Priess JR, Horvitz HR, Han M. unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration. Development. 2001 Dec;128(24):5039-50. PMID: 11748140.

Chen Z, Han M. Role of C. elegans lin-40 MTA in vulval fate specification and morphogenesis. Development. 2001 Dec;128(23):4911-21. PMID: 11731470.

Chen Z, Han M. C. elegans Rb, NuRD, and Ras regulate lin-39-mediated cell fusion during vulval fate specification. Curr Biol. 2001 Nov 27;11(23):1874-9. PMID: 11728311.

Spencer AG, Orita S, Malone CJ, Han M. A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13132-7. Epub 2001 Oct 30. PMID: 11687661; PMCID: PMC60836.

Yoder JH, Han M. Cytoplasmic dynein light intermediate chain is required for discrete aspects of mitosis in Caenorhabditis elegans. Mol Biol Cell. 2001 Oct;12(10):2921-33. PMID: 11598181; PMCID: PMC60145.

Zhang K, Kniazeva M, Han M, Li W, Yu Z, Yang Z, Li Y, Metzker ML, Allikmets R, Zack DJ, Kakuk LE, Lagali PS, Wong PW, MacDonald IM, Sieving PA, Figueroa DJ, Austin CP, Gould RJ, Ayyagari R, Petrukhin K. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet. 2001 Jan;27(1):89-93. PMID: 11138005.

Hanna-Rose W, Han M. Getting signals crossed in C. elegans. Curr Opin Genet Dev. 2000 Oct;10(5):523-8. Review. PMID: 10980430.

Fay DS, Han M. Mutations in cye-1, a Caenorhabditis elegans cyclin E homolog, reveal coordination between cell-cycle control and vulval development. Development. 2000 Sep;127(18):4049-60. PubMed PMID: 10952902.

Grant K, Hanna-Rose W, Han M. sem-4 promotes vulval cell-fate determination in Caenorhabditis elegans through regulation of lin-39 Hox. Dev Biol. 2000 Aug 15;224(2):496-506. PubMed PMID: 10926783.

Kniazeva M, Traboulsi EI, Yu Z, Stefko ST, Gorin MB, Shugart YY, O'Connell JR, Blaschak CJ, Cutting G, Han M, Zhang K. A new locus for dominant drusen and macular degeneration maps to chromosome 6q14. Am J Ophthalmol. 2000 Aug;130(2):197-202. PMID: 11004294.

Chen Z, Han M. Building a protein interaction map: research in the post-genome era. Bioessays. 2000 Jun;22(6):503-6. Review. PMID: 10842303.

Li W, Han M, Guan KL. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Genes Dev. 2000 Apr 15;14(8): 895-900. PMID: 10783161; PMCID: PMC316541.

Fay DS, Han M. The synthetic multivulval genes of C. elegans: functional redundancy, Ras-antagonism, and cell fate determination. Genesis. 2000 Apr;26(4):279-84. Review. PMID: 10748467.

Zhang K, Garibaldi DC, Kniazeva M, Albini T, Chiang MF, Kerrigan M, Sunness JS, Han M, Allikmets R. A novel mutation in the ABCR gene in four patients with autosomal recessive Stargardt disease. Am J Ophthalmol. 1999 Dec;128(6):720-4. PMID: 10612508.

Sieburth DS, Sundaram M, Howard RM, Han M. A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction. Genes Dev. 1999 Oct 1;13(19):2562-9. PMID: 10521400; PMCID: PMC317062.

Zhang K, Kniazeva M, Hutchinson A, Han M, Dean M, Allikmets R. The ABCR gene in recessive and dominant Stargardt diseases: a genetic pathway in macular degeneration. Genomics. 1999 Sep 1;60(2):234-7. PMID: 10486215.

Stewart S, Sundaram M, Zhang Y, Lee J, Han M, Guan KL. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol Cell Biol. 1999 Aug;19(8):5523-34. PMID: 10409742; PMCID: PMC84397.

Guan KL, Han M. A G-protein signaling network mediated by an RGS protein. Genes Dev. 1999 Jul 15;13(14):1763-7. Review. PMID: 10421628.

Kniazeva M, Chiang MF, Cutting GR, Zack DJ, Han M, Zhang K. Clinical and genetic studies of an autosomal dominant cone-rod dystrophy with features of Stargardt disease. Ophthalmic Genet. 1999 Jun;20(2):71-81. PMID: 10420191.

Malone CJ, Fixsen WD, Horvitz HR, Han M. UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. Development. 1999 Jun;126(14):3171-81. PMID: 10375507.

Kniazeva M, Chiang MF, Morgan B, Anduze AL, Zack DJ, Han M, Zhang K. A new locus for autosomal dominant stargardt-like disease maps to chromosome 4. Am J Hum Genet. 1999 May;64(5):1394-9. PMID: 10205271; PMCID: PMC1377876.

Yochem J, Tuck S, Greenwald I, Han M. A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting. Development. 1999 Feb;126(3):597-606. PMID: 9876188.

Fay DS, Stanley HM, Han M, Wood WB. A Caenorhabditis elegans homologue of hunchback is required for late stages of development but not early embryonic patterning. Dev Biol. 1999 Jan 15;205(2):240-53. PMID: 9917360.

Hanna-Rose W, Han M. COG-2, a sox domain protein necessary for establishing a functional vulval-uterine connection in Caenorhabditis elegans. Development. 1999 Jan;126(1):169-79. PMID: 9834196.

Sternberg PW, Han M. Genetics of RAS signaling in C. elegans. Trends Genet. 1998 Nov;14(11):466-72. Review. PMID: 9825675.

Gu T, Orita S, Han M. Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction. Mol Cell Biol. 1998 Aug;18(8):4556-64. PMID: 9671465; PMCID: PMC109041.

Sieburth DS, Sun Q, Han M. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell. 1998 Jul 10;94(1):119-30. PMID: 9674433.

Yochem J, Gu T, Han M. A new marker for mosaic analysis in Caenorhabditis elegans indicates a fusion between hyp6 and hyp7, two major components of the hypodermis. Genetics. 1998 Jul;149(3):1323-34. PMID: 9649523; PMCID: PMC1460238.

Sugimoto T, Stewart S, Han M, Guan KL. The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation. EMBO J. 1998 Mar 16;17(6):1717-27. PMID: 9501093; PMCID: PMC1170519.

Dent JA, Han M. Post-embryonic expression pattern of C. elegans let-60 ras reporter constructs. Mech Dev. 1998 Mar;72(1-2):179-82. PMID: 9533963.

Han M. Gut reaction to Wnt signaling in worms. Cell. 1997 Aug 22;90(4):581-4. Review. PMID: 9288737.

Yochem J, Sundaram M, Han M. Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans. Mol Cell Biol. 1997 May;17(5):2716-22. PMID: 9111342; PMCID: PMC232122.

Zhang K, Yeon H, Han M, Donoso LA. Molecular genetics of macular dystrophies. Br J Ophthalmol. 1996 Nov;80(11):1018-22. Review. PMID: 8976733; PMCID: PMC505683.

Sundaram M, Yochem J, Han M. A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans. Development. 1996 Sep;122(9):2823-33. PMID: 8787756.

Sundaram M, Han M. Control and integration of cell signaling pathways during C. elegans vulval development. Bioessays. 1996 Jun;18(6):473-80. Review. PMID: 8787535.

Sundaram M, Han M. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell. 1995 Dec 15;83(6):889-901. PMID: 8521513.

Singh N, Han M. sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction. Genes Dev. 1995 Sep 15;9(18):2251-65. PMID: 7557379.

Hara M, Han M. Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3333-7. PMID: 7536929; PMCID: PMC42160.

Wu Y, Han M, Guan KL. MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events. Genes Dev. 1995 Mar 15;9(6):742-55. PMID: 7729690.

Wu Y, Han M. Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation. Genes Dev. 1994 Jan;8(2): 147-59. PMID: 8299935.

Sternberg PW, Golden A, Han M. Role of a raf proto-oncogene during Caenorhabditis elegans vulval development. Philos Trans R Soc Lond B Biol Sci. 1993 Jun 29;340 (1293):259-65. PMID: 8103927.

Han M, Golden A, Han Y, Sternberg PW. C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation. Nature. 1993 May 13;363(6425):133-40. PMID: 8483497.

Han M. Ras proteins in developmental pattern formation in Caenorhabditis elegans and Drosophila. Semin Cancer Biol. 1992 Aug;3(4):219-28. Review. PMID: 1421166.

Han M, Sternberg PW. Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene. Genes Dev. 1991 Dec;5(12A):2188-98. PMID: 1748278.

Han M, Aroian RV, Sternberg PW. The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans. Genetics. 1990 Dec;126(4): 899-913. PMID: 2076820; PMCID: PMC1204287.

Han M, Sternberg PW. let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein. Cell. 1990 Nov 30;63(5):921-31. PMID: 2257629.

Han M, Grunstein M. Nucleosome loss activates yeast downstream promoters in vivo. Cell. 1988 Dec 23;55(6):1137-45. PMID: 2849508.

Kayne PS, Kim UJ, Han M, Mullen JR, Yoshizaki F, Grunstein M. Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast. Cell. 1988 Oct 7;55(1):27-39. PMID: 3048701.

Kim UJ, Han M, Kayne P, Grunstein M. Effects of histone H4 depletion on the cell cycle and transcription of Saccharomyces cerevisiae. EMBO J. 1988 Jul;7(7):2211-9. PMID: 3046933; PMCID: PMC454562.

Han M, Kim UJ, Kayne P, Grunstein M. Depletion of histone H4 and nucleosomes activates the PHO5 gene in Saccharomyces cerevisiae. EMBO J. 1988 Jul;7(7):2221-8. PMID: 3046934; PMCID: PMC454566.

Han M, Chang M, Kim UJ, Grunstein M. Histone H2B repression causes cell-cycle-specific arrest in yeast: effects on chromosomal segregation, replication, and transcription. Cell. 1987 Feb 27;48(4):589-97. PMID: 3815518.

Schuster T, Han M, Grunstein M. Yeast histone H2A and H2B amino termini have interchangeable functions. Cell. 1986 May 9;45(3):445-51. PMID: 3516414.

Yoshinaga S, Dean N, Han M, Berk AJ. Adenovirus stimulation of transcription by RNA polymerase III: evidence for an E1A-dependent increase in transcription factor IIIC concentration. EMBO J. 1986 Feb;5(2):343-54. PMID: 2940084; PMCID: PMC1166738.