Research

Alex publishes in Advanced Healthcare Materials about clickable microgel scaffolds

May 10, 2017

Alex Caldwell publishes a synthetic bottom-up fabrication process for microgel building blocks with clickable surface groups to make porous cell-laden scaffolds. Follow this link to read the full maunscript !Read more »

Hao & Anouk co-author a paper on spatial matrix variations and myofibroblast activation

April 10, 2017

Hao Ma and Anouk Killaars co-authored this work appearing in Biomaterials. In this paper, they investigated the role of spatial variations in matrix elasticity and its organization on myofibroblastic activation on valvular interstitial cells. Check out the full article here !Read more »
microgel sensors of protease activity

Della Shin publishes on microgel sensors for protease activity

March 27, 2017

In this work, Della develops fluorescent microgel sensors for the three-dimensional monitoring of cellular protease activity. These sensors are then used to monitor protease activity of melanoma cancer cells. Check out the full article here!Read more »

Controlled drug release from host-guest hydrogels one of J. Mater. Chem. B's most accessed articles of 2016

March 3, 2017

Congratulations to Michael and Adrianne for publishing one of the most accessed articles of 2016 in Journal of Materials Chemistry B . Find the full list here .Read more »

Tobin and Ian publish on allyl sulfide-based photodegradable hydrogels

Jan. 23, 2017

Ian Marozas and Tobin Brown co-authored this work, appearing online today in Advanced Materials . In this report, they investigate the use of reversible thiol-ene radical chemistry to rapidly photodegrade cell-laden hydrogels.Read more »

Emi reports on the effect of dimensionality on melanoma drug sensitivity

Jan. 20, 2017

In this work, Emi Tokuda (currently at the Seattle Children's Hospital) investigates the effect of culture conditions, including dimensionality and cell-cell contacts, on the responsiveness of early- and late-stage melanoma cell lines towards cancer drugs. Find it here .Read more »
Nehls Abstract

Michael and Adrianne report on controlled drug delivery based on host/guest interactions from PEG hydrogels

Feb. 2, 2016

In this paper, former undergraduate research Michael Nehls and postdoc Adrianne Rosales demonstrate control over release kinetics of a model peptide drug based on a photo-switchable host/guest interaction between azobenzene and cyclodextrin. Check it out here !Read more »

Adrianne Rosales publishes a review of reversible hydrogel strategies in Nature Reviews Materials

Feb. 2, 2016

This excellent review summarizes many of the techniques used to make reversible hydrogels. Whether the reversibility is in the crosslinks themselves, or in pendant functional groups, these gels have many interesting and exciting properties. Check it out online here .Read more »
Malar and Ian figure

Malar and Ian publish "Photoregulated hydrazone-based hydrogel formation for biochemically patterning 3D cellular microenvironments" in ACS Macro Letters

Jan. 13, 2016

In this paper, the authors describe a hydrazone crosslinked hydrogel formed by the reaction of photo-generated aldehydes with pendant hydrazine functionalities. The same reaction is also used to pattern biochemical ligands within the gel. Check it out !Read more »

Kelly Mabry publishes "Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype" in Biomaterials

Dec. 21, 2015

In her latest publication, recent PhD graduate Kelly Mabry analyzes the differences in gene expression between freshly isolated valvular interstitial cells (VICs) and those cultured on conventional tissue culture plastic, on two-dimensional hydrogels, and encapsulated within three-dimensional hydrogels. Check it out here !Read more »

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