Research

Emi reports on the effect of dimensionality on melanoma drug sensitivity

Jan. 20, 2017

In this work, Emi Tokuda (currently at the Seattle Children's Hospital) investigates the effect of culture conditions, including dimensionality and cell-cell contacts, on the responsiveness of early- and late-stage melanoma cell lines towards cancer drugs. Find it here .Read more »
Nehls Abstract

Michael and Adrianne report on controlled drug delivery based on host/guest interactions from PEG hydrogels

Feb. 2, 2016

In this paper, former undergraduate research Michael Nehls and postdoc Adrianne Rosales demonstrate control over release kinetics of a model peptide drug based on a photo-switchable host/guest interaction between azobenzene and cyclodextrin. Check it out here !Read more »

Adrianne Rosales publishes a review of reversible hydrogel strategies in Nature Reviews Materials

Feb. 2, 2016

This excellent review summarizes many of the techniques used to make reversible hydrogels. Whether the reversibility is in the crosslinks themselves, or in pendant functional groups, these gels have many interesting and exciting properties. Check it out online here .Read more »
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Malar and Ian publish "Photoregulated hydrazone-based hydrogel formation for biochemically patterning 3D cellular microenvironments" in ACS Macro Letters

Jan. 13, 2016

In this paper, the authors describe a hydrazone crosslinked hydrogel formed by the reaction of photo-generated aldehydes with pendant hydrazine functionalities. The same reaction is also used to pattern biochemical ligands within the gel. Check it out !Read more »

Kelly Mabry publishes "Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype" in Biomaterials

Dec. 21, 2015

In her latest publication, recent PhD graduate Kelly Mabry analyzes the differences in gene expression between freshly isolated valvular interstitial cells (VICs) and those cultured on conventional tissue culture plastic, on two-dimensional hydrogels, and encapsulated within three-dimensional hydrogels. Check it out here !Read more »

Two recent articles highlighted in Noteworthy Chemistry feature by ACS

June 11, 2015

Noteworthy Chemistry , a weekly publication by the ACS that highlights specific articles from a broad range of literature, selected two of our articles for their feature. Photocontrolled Nanoparticles for On-Demand Release of Proteins was highlighted in September, 2012 , and Synthetically Tractable Click Hydrogels for Three-Dimensional Cell Culture Formed... Read more »

Kelly Mabry publishes "Dynamic stiffening of poly(ethylene glycol)-based hydrogels to direct valvular interstitial cell phenotype in a three-dimensional environment"

May 28, 2015

In this work, Kelly investigates the effect of dynamic hydrogel stiffening on encapsulated VICs. Check out the article (appearing in the journal Biomaterials ) here .Read more »

Jen Leight and Emi Tokuda publish "Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition" in PNAS

April 14, 2015

In this work, Jen (now at Ohio State) and Emi (now at Seattle Children's Hospital) investigate the effect of cancer drugs on matrix metalloproteinase (MMP) and metabolic activity of melanoma cells at various stages of metastasis. Their findings suggest that current clinical drugs can upregulate MMP activity, causing increased metastatic... Read more »
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Katie Lewis publishes "In vitro model alveoli from photodegradable microsphere templates" in Biomaterials Science

April 2, 2015

In this work, Katie uses photodegradable hydrogel microparticles to create three dimensional cyst-like structures to mimic the native alveoli of the lung epithelium. Check out the article here !Read more »
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"Development of a Cellularly Degradable PEG Hydrogel to Promote Articular Cartilage Extracellular Matrix Deposition" accepted to Advanced Healthcare Materials.

Jan. 30, 2015

In this paper, Balaji Sridhar demonstrates improved glycosaminoglycan and collagen deposition by co-encapsulating chondrocytes and MSCs in a functionalized cell-degradable PEG hydrogel. Check it out here !Read more »

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